2007, Number 4
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Rev Endocrinol Nutr 2007; 15 (4)
Physiological changes during the aging of the male reproductive system
Lamm WL, Porias CH
Language: Spanish
References: 71
Page: 207-216
PDF size: 141.77 Kb.
ABSTRACT
The advances in the medical research have provided a greater life expectancy as much in men and women, and consequently it has brought a better understanding of the physiological and degenerative basis for the aging process. Recently, interest has been gained in this field, particularly in elderly men. There are too many alterations in different organs and systems as a result of the ageing process and great part of these are consequence of the experienced changes in the male reproductive system. All the described alterations involve changes that can occur at any level of the hypothalamic-hypophysis - gonadal axis. Nevertheless, it is the testicle which displays the greatest degenerative changes resulting in structural alterations, deficient hormonal production, semen quality and sexual function. On the other hand, the penis also experiences changes related to the erectile function, that beyond being a consequence of associated co-morbidities and relative hormonal deficiency, it is also the result of its own degenerative process due to aging.
REFERENCES
Morales A, Bain J, Ruijs A, Chapdelaine A, Remblay RR. Clinical practice guidelines for screening and monitoring male patients receiving testosterone supplementation therapy. Int J Impotence Res 1996; (8): 95-97.
Anderson FH, Francis RM, Faulkner K. Androgen supplementation in eugonadal men with osteoporosis-effects of 6 months of treatment on bone mineral density and cardiovascular risks factors. Bone 1996; (18): 171-177.
Gooren LJG. The age related decline of androgen levels in men: clinically significant? Br J Urol 1996; (78): 763-768.
Well D, Yang H, Houseni M. Age-related structural and metabolic changes in the pelvic reproductive end organs. Semin Nucl Med 2007; (37): 173-184.
Morley JE, Kaiser FE, Perry HM, Patrick P, Morley PM, Stauber PM, Vellas B, Baumgartner RN, Garry PJ. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997; (46): 410-413.
Mahmoud AM, Goemaere S, El-Garem Y. Testicular volume in relation to hormonal indices of gonadal function in community-dwelling elderly men. J Clin Endocrinol Metab 2003; (88): 179-184
Handelsman DJ, Spaliviero JA, Phippard AF. Highly vectorial secretion of inhibin by primate Sertoli cells in vitro. Journal of Clinical Endocrinology and Metabolism 1990; (71): 1235-1238.
Risbridger GP, Clements J, Robertson DM. Immuno- and bioactive inhibin and inhibin alpha-subunit expression in rat Leydig cell cultures. Molecular and Cellular Endocrinology 1989; (66): 119-122.
Meachem SJ, Nieschlag E, Simoni M. Inhibin B in male reproduction: pathophysiology and clinical relevance. European Journal of Endocrinology. 2001; (145): 561-571.
Byrd W, Bennett MJ, Carr BR. Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male. Journal of Clinical Endocrinology and Metabolism 1998; (83): 2849-2854.
Crofton PM, Illingworth PJ, Groome NP, Stirling HF, Swanston I, Gow S et al. Changes in dimeric inhibin A and B during normal early puberty in boys and girls. Clinical Endocrinology 1997; (46): 109-114.
Andersson AM, Toppari J, Haavisto AM, Petersen JH, Simell T, Simell O et al. Longitudinal reproductive hormone profiles in infants: peak of inhibin B levels in infant boys exceeds levels in adult men. Journal of Clinical Endocrinology and Metabolism 1998; (83): 675-681.
Anawalt BD, Bebb RA, Matsumoto AM, Groome NP, Illingworth PJ, McNeilly AS et al. Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction. Journal of Clinical Endocrinology and Metabolism 1996; (81): 3341-3345.
Kidd SA, Eskenazi B, Wyrobek AJ. Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001; (75): 237-248.
Ferrini RL, Barrett-Connor E. Sex hormones and age: a cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men. Am J Epidemiol 1998; (147): 750-754.
Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 2001; (86): 724-731.
Vermeulen A, Kaufman JM. Role of the hypothalamo-pituitary function in the hypoandrogenism of healthy aging. J Clin Endocrinol Metab 1992; (75): 704-706.
Kaufman JM, Vermeulen A. Declining gonadal function in elderly men. Baillieres Clin Endocrinol Metab 1997; (11): 289-309.
Ariyaratne HBS, Mills N, Mason JI, Mendis-Handagama SMLC. Effects of thyroid hormone on Leydig cell regeneration in the adult rat following ethane dimethane sulfonate treatment. Biol Reprod 2000; (63): 1115-1123.
Mendis-Handagama SMLC, Ariyaratne HBS, Teunissen van Manen KR, Haupt RL. Differentiation of adult Leydig cells in the neonatal rat testis is arrested by hypothyroidism. Biol Reprod 1998; (59): 351-357.
Teerds KJ, Rooij DG, de Jong FH, van Haaster LH. The development of the adult type Leydig cell population in the rat testis is affected by neonatal thyroid hormone levels. Biol Reprod 1998; (59): 344-350.
In-shik K, Ariyaratne HBS, Mendis-Handagama Ch. Changes in the testis interstitium of brown norway rats with aging and effects of luteinizing and thyroid hormones on the aged testes in enhancing the steroidogenic potential. Biology of Reproduction 2002; (66): 1359-1366.
Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001; (17): 387-403.
Weissman IL. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 2000; (287): 1442 -1446.
Brinster RL. Germline stem cell transplantation and transgenesis. Science 2002; (296): 2174-2176.
Potten CS, Owen G, Booth D. Intestinal stem cells protect their genome by selective segregation of template DNA strands. J Cell Sci 2002; (115): 2381-2388.
Cairns J. Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc Natl Acad Sci USA 2002; (99): 10567-10570.
Holliday R. Senescence of dividing somatic cells. In: Marshak DR, Gardner RL, Gottlieb D, (eds.). Stem cell biology. Cold Spring Harbor: Cold Spring Harbor Laboratory Press; 2001: 95-109.
Dolci S, Levati L, Pellegrini M, Faraoni I, Graziani G, Di Carlo A, Geremia R. Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells. J Cell Sci 2002; (115): 1643-1649.
Xiangfan Z, Kevin TE, Bernard R. Biology of reproduction. 2006; (74): 119-124.
Vermuelen A, Rubens R, Verdonck AL. Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 1972; (34): 730-735.
Neaves WB, Johnson L, Porter JC et al. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab 1984; (59): 756-763.
Johnson L, Zane RS, Petty CS et al. Quantification of the human Sertoli cell population: Its distribution, relation to germ cell numbers, and age-related decline. Biol Reprod 1984; (31): 785-795.
Untergasser G, Madersbacher S, Berger P. Benign prostatic hyperplasia: Age-related tissue-remodeling. Exp Gerontol 2005; (40): 121-128.
Bostwick DG, Cooner WH, Denis L et al. The association of benign prostatic hyperplasia and cancer of the prostate. Cancer 1992; (70): 291-301.
Jungblut T, Aumuller G, Malek B et al. Age-dependency and regional distribution of enkephalinergic nerves in human prostate. Urol Int 1989; (44): 352-356.
Takeda M, Tang R, Shapiro E et al. Effects of nitric oxide on human and canine prostates. Urology 1995; (45): 440-446.
Roberts RO, Jacobson DJ, Rhodes T et al. Serum sex hormones and measures of benign prostatic hyperplasia. Prostate 2004; (61): 124-131.
Shibata Y, Ito K, Suzuki K et al. Changes in the endocrine environment of the human prostate transition zone with aging: simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition. Prostate 2000; (42): 45-55.
Silver RI, Wiley EL, Thigpen AE et al. Cell type specific expression of steroid 5 alpha-reductase 2. J Urol 1994; (152): 438-442.
Pasqualotto FF, Sobreiro BP, Hallak J et al. Sperm concentration and normal sperm morphology decrease and follicle stimulating hormone level increases with age. BJU Int 2005; (96): 1087-1091.
Tenover JS. Declining testicular function in aging men. Int J Impot Res 2003; (4): S3-S8 (Suppl 15).
Harman SM, Metter EJ, Tobin JD et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2001; (86): 724-731.
Auger J, Jouannet P. Age and male fertility: biological factors. Rev Epidemiol Sante Publique 2005; (53): 25-35.
Forbes GB. Longitudinal changes in adult body composition: Influence of body weight. Appl Radiat Isot 1998; (49): 571-573.
Stellato RK, Feldman HA, Hamdy O et al. Testosterone, sex hormone binding globulin, and the development of type 2 diabetes in middleaged men: prospective results from the Massachusetts male aging study. Diabetes Care 2000; (23): 490-494.
Meier DE, Orwoll ES, Keenan EJ et al. Marked decline in trabecular bone mineral content in healthy men with age: Lack of association with sex steroid levels. J Am Geriatr Soc 1987; (35): 189-197.
Orwoll E, Ettinger M, Weiss S et al. Alendronate for the treatment of osteoporosis in men. N Engl J Med 2000; (343): 604-610.
Wilson MM, Morley JE. Invited review: Aging and energy balance. J Appl Physiol 2003; (95): 1728-1736.
Carreau S, Bourguiba S, Marie E. Testicular and blood steroid levels in aged men. Reprod Biol 2004; (4): 299-304.
Nieschlag E, Lammers U, Freischem CW, Langer K, Wickings EJ. Reproductive function in young fathers and grandfathers. Journal of Clinical Endocrinology and Metabolism 1982; (55): 676-681.
Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. Journal of Clinical Endocrinology and Metabolism 1996; (81): 1821-1826.
Turner HE, Wass JAH. Gonadal function in men with chronic illness. Clinical Endocrinology 1997; (47): 379-401.
Spratt DI, Cox P, Orav J, Moloney J, Bigos T. Reproductive axis suppression in acute illness is related to disease severity. Journal of Clinical Endocrinology and Metabolism 1993; (76): 1548-1554.
Kaufman JM, Vermeulen A. Declining gonadal function in elderly men. Baillieres Clinical Endocrinology and Metabolism 1997; (11): 289-309.
Matsumoto AM. Andropause: clinical implications of the decline in serum testosterone levels with aging in men. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2002; (57): 76-99.
Allen NE, Appleby PN, Davey GK, Key TJ. Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men. Causes and Control 2002; (13): 353-363.
Muller M, Tonkelaar I, Thijssen J. Endogenous sex hormones in men aged 40-80 years. European Journal of Endocrinology 2003; (149): 583-589.
Gray A, Feldman HA, McKinlay JB et al. Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab 1991; (73): 1016-1025.
Feldman HA, Longcope C, Derby CA et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 2002; (87): 589-598.
Sagel J, Distiller LA, Morley JE et al. Myotonia dystrophica: Studies on gonadal function using luteinizing hormone-releasing hormone (LRH). J Clin Endocrinol Metab 1975; (40): 1110-1113.
Veldhuis JD, Jonson ML, Iranmanesh A. The ensemble male hypothalamo-pituitary-gonadal axis. Physiological basis of aging and geriatrics. 2nd ed. 2004; (12): 225-235.
McKinlay JB. The worldwide prevalence and epidemiology of erectile dysfunction. Int J Impot Res 2000; Suppl., 12: S6.
Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-56.
Allen D. Seftel. Erectile dysfunction in the elderley: Epidemiology, etiology and approaches to treatment. J Urol 2003; 169: 1999-2007.
McVary KT. Erectile dysfunction. In: Harrison’s Principles of Internal Medicine. 15th ed. Edited by Braunwald E, Fauci AS, Kasper DL et al. New York: McGraw-Hill Publishers, chapt. 51, in press, 2001.
Burris AS, Banks SM, Carter CS et al. A long-term prospective study of the physiologic and behavioural effects of hormone replacement in untreated hypogonadal men. J Androl 1992; 13: 297-304.
Akkus E, Carrier S, Baba K, Hsu GL, Padma-Nathan H, Nunes L et al. Structural alterations in the tunica albuginea of the penis: impact of Peyronie’s disease, aging and impotence. Br J Urol 1007; (79): 47-55.
Vanegas JP, Raviv G, Kiss R, Petein M, Louis L, Danguy A et al. Intracavernous collagen analysis in impotence. Acta Urol Belg 1996; (64): 7-13.
Rowland DL, Greenleaf W, Mas M, Myers L, Davidson JM. Penile and finger sensory thresholds in young, aging, and diabetic males. Arch Sex Behav 1989; (18): 1-8.
Garban H, Vernet D, Freedman A, Rajfer J, Gonzalez-Cadavid N. Effect of aging on nitric oxide-mediated penile erection in rats. Am J Physiol 1995; (268): H467-474.