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Colegio de Medicina Interna de México.

2006, Number 5

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Med Int Mex 2006; 22 (5)

Phisiopathology of cholestasis

García GC

Language: Spanish
References: 25
Page: 411-421
PDF size: 298.81 Kb.


ABSTRACT

The present review analyzes one of the most vital functions of our organism, carried out by the liver consisting of the formation and secretion of bile; which is mainly composed of bile salts that participate in the fat absorption of the diet and also in the excretion of mostly cholesterol. These substances are strictly regulated by keeping a constant pool through the integration of the enterohepatic axis. Further more, one of the most complex aspects is constituted by the discovery of a substantial amount of transporters, which participate in the strict regulation of this function. The recognition of the membrane proteins has impressively developed in the past ten years, and in regards to this matter it has been possible to define its structure, acknowledging many aspects of its functions, and also several of its substrates that move through cell membranes have been defined; in addition various genetic mutations have been described, resulting in their own structural or functional alterations, originating well defined diseases. Many of the aspects above are mentioned in the present review.


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