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Revista Latinoamericana de Microbiología

2004, Number 3-4

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Microbiología 2004; 46 (3-4)

Current aspects of Shigella Pathogenesis

Torres AG

Language: English
References: 53
Page: 89-97
PDF size: 108.50 Kb.


ABSTRACT

Bacillary dysentery (shigellosis) is a severe human disease caused by Shigellae. In recent years, a large amount of information has been generated regarding the host, pathogen and environmental factors that impact the pathogenesis of shigellosis at the cellular and molecular level. This review summarizes what is currently known about Shigella, detailing those factors that contribute to pathogenesis and examining the current progress in the development of a vaccine.


REFERENCES

  1. Al-Hasani, K., K. Rajakumar, D. Bulach, R. Robins-Browne, B. Adler, & H. Sakellaris. 2001. Genetic organization of the she pathogenicity island in Shigella flexneri 2a. Microb. Pathog. 30:1-8.

  2. Bahrani, F. K., P. J. Sansonetti, & C. Parsot. 1997. Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation. Infect. Immun. 65:4005-4010.

  3. Bernardini, M. L., A. Fontaine, & P. J. Sansonetti. 1990. The two-component regulatory system OmpR-EnvZ controls the virulence of Shigella flexneri. J. Bacteriol. 172:6274-6281.

  4. Bernardini, M. L., J. Mounier, H. d’Hauteville, M. Coquis-Rondon, & P. J. Sansonetti. 1989. Identification of icsA, a plasmid locus of Shigella flexneri which governs bacterial intra- and intercellular spread through interaction with F-actin. Proc. Natl. Acad. Sci. USA 86:3867-3871.

  5. Buchrieser, C., P. Glaser, C. Rusniok, H. Nedjari, H. d’Hauteville, F. Kunst, P. Sansonetti, & C. Parsot. 2000. The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri. Mol. Microbiol. 38:760-771.

  6. Cohen, D., S. Ashkenazi, M. S. Green, M. Gdalevich, G. Robin, R. Slepon, M. Yavzori, N. Orr, C. Block, I. Ashkenazi, J. Shemer, D. N. Taylor, T. L. Hale, J. C. Sadoff, D. Pavliakova, R. Schneerson & J. B. Robbins. 1997. Double-blind vaccine-controlled randomized efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults. Lancet 349:155-159.

  7. Coster, T. S., C. W. Hoge, L. L. VanDeVerg, A. B. Hartman, E. V. Oaks, M. M. Venkatesan, D. Cohen, G. Robin, A. Fontaine-Thompson, P. J. Sansonetti, & T. L. Hale. 1999. Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602. Infect. Immun. 67:3437-3443.

  8. Day, W. A., Jr., & A. T. Maurelli. 2001. Shigella flexneri LuxS quorum-sensing system modulates virB expression but is not essential for virulence. Infect. Immun. 69:15-23.

  9. Dorman, C. J., & M. E. Porter. 1998. The Shigella virulence gene regulatory cascade: a paradigm of bacterial gene control mechanisms. Mol. Microbiol. 29:677-684.

  10. Fernandez, M. I., & P. J. Sansonetti. 2003. Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis. Int. J. Med. Microbiol. 293:55-67.

  11. Hale, T. L. 1991. Genetic basis of virulence in Shigella species. Microbiol. Rev. 55:206-224.

  12. Hong, M., & S. M. Payne. 1997. Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipopolysaccharide genes on invasion and serum resistance. Mol. Microbiol. 24:779-791.

  13. Hromockyj, A. E., & A. T. Maurelli. 1989. Identification of an Escherichia coli gene homologous to virR, a regulator of Shigella virulence. J. Bacteriol. 171:2879-81.

  14. Ingersoll, M., E. A. Groisman, & A. Zychlinsky. 2002. Pathogenicity islands of Shigella. Curr. Top. Microbiol. Immunol. 264:49-65.

  15. Ingersoll, M. A., J. E. Moss, Y. Weinrauch, P. E. Fisher, E. A. Groisman, & A. Zychlinsky. 2003. The ShiA protein encoded by the Shigella flexneri SHI-2 pathogenicity island attenuates inflammation. Cell Microbiol. 5:797-807.

  16. Jin, Q., Z. Yuan, J. Xu, Y. Wang, Y. Shen, W. Lu, J. Wang, H. Liu, J. Yang, F. Yang, X. Zhang, J. Zhang, G. Yang, H. Wu, D. Qu, J. Dong, L. Sun, Y. Xue, A. Zhao, Y. Gao, J. Zhu, B. Kan, K. Ding, S. Chen, H. Cheng, Z. Yao, B. He, R. Chen, D. Ma, B. Qiang, Y. Wen, Y. Hou, & J. Yu. 2002. Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 30:4432-4441.

  17. Kopecko, D. J., O. Washington, & S. B. Formal. 1980. Genetic and physical evidence for plasmid control of Shigella sonnei Form I cell surface antigen. Infect. Immun. 29:207-214.

  18. Kotloff, K. L., F. R. Noriega, T. Samandari, M. B. Sztein, G. A. Losonsky, J. P. Nataro, W. D. Picking, E. M. Barry, & M. M. Levine. 2000. Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans. Infect. Immun. 68:1034-1039.

  19. Kotloff, K. L., J. P. Winickoff, B. Ivanoff, J. D. Clemens, D. L. Swerdlow, P. J. Sansonetti, G. K. Adak, & M. M. Levine. 1999. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. World Health Org. 77:651-666.

  20. Luck, S. N., S. A. Turner, K. Rajakumar, H. Sakellaris, & B. Adler. 2001. Ferric dicitrate transport system (Fec) of Shigella flexneri 2a YSH6000 is encoded on a novel pathogenicity island carrying multiple antibiotic resistance genes. Infect. Immun. 69:6012-6021.

  21. Makino, S., C. Sasakawa, K. Kamata, T. Kurata, & M. Yoshikawa. 1986. A genetic determinant required for continuous reinfection of adjacent cells on large plasmid in Shigella flexneri 2a. Cell 46:551-555.

  22. Maurelli, A. T., R. E. Fernandez, C. A. Bloch, C. K. Rode, & A. Fasano. 1998. “Black holes” and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli. Proc. Natl. Acad. Sci. USA 95: 3943-3948.

  23. Maurelli, A. T., & P. J. Sansonetti. 1988. Genetic determinants of Shigella pathogenicity. Ann. Rev. Microbiol. 42:127-150.

  24. Melton-Celsa, A. R., & A. D. O’Brien. 1998. Structure, biology, and relative toxicity of Shiga toxin family members for cells and animals., p. 121-128. In J. B. K. a. A. D. O’Brien (ed.), Escherichia coli O157:H7 and other Shiga toxin-producing E. coli. American Society for Microbiology, Washington, D.C.

  25. Moss, J. E., T. J. Cardozo, A. Zychlinsky, & E. A. Groisman. 1999. The selC-associated SHI-2 pathogenicity island of Shigella flexneri. Mol. Microbiol. 33:74-83.

  26. Nakayama, S.-I., & H. Watanabe. 1995. Involvement of cpxA, a sensor of a two-component regulatory system, in the pH-dependent regulation of expression of Shigella sonnei virF gene. J. Bacteriol. 177:5062-5069.

  27. O’Brien, A. D., V. L. Tesh, A. Donohue-Rolfe, M. P. Jackson, S. Olsnes, K. Sandvig, A. A. Lindberg, & G. T. Keusch. 1992. Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis., p. 66-94. In P. J. Sansonetti (ed.), Pathogenesis of Shigellosis. Springer-Verlag KG, Berlin-Heidelberg, Germany.

  28. Okada, N., C. Sasakawa, T. Tobe, M. Yamada, S. Nagai, K. A. Talukder, K. Komatsu, S. Kanegasaki, & M. Yoshikawa. 1991. Virulence-associated chromosomal loci of Shigella flexneri identified by random Tn5 insertion mutagenesis. Mol. Microbiol. 5:187-195.

  29. Passwell, J. H., E. Harlev, S. Ashkenazi, C. Chu, D. Miron, R. Ramon, N. Farzan, J. Shiloach, D. A. Bryla, F. Majadly, R. Roberson, J. B. Robbins & R. Schneerson. 2001. Safety and immunogenicity of improved Shigella O-specific polysaccharide-protein conjugate vaccines in adults in Israel. Infect. Immun. 69:1351-1357.

  30. Payne, S. M. 1989. Iron and virulence in Shigella. Mol. Microbiol. 3:1301-1306.

  31. Philpott, D. J., J. D. Edgeworth, & P. J. Sansonetti. 2000. The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies. Phil. Trans. R.Soc. Lond. B Biol. Sci. 355:575-586.

  32. Prosseda, G., M. Falconi, M. Nicoletti, M. Casalino, G. Micheli, & B. Colonna. 2002. Histone-like proteins and the Shigella invasivity regulon. Res. Microbiol. 153:461-468.

  33. Purdy, G. E., & S. M. Payne. 2001. The SHI-3 iron transport island of Shigella boydii O-1392 carries the genes for aerobactin synthesis and transport. J. Bacteriol. 183:4176-4182.

  34. Rajakumar, K., C. Sasakawa, & B. Adler. 1997. Use of a novel approach, termed island probing, identifies the Shigella flexneri she pathogenicity island which encodes a homolog of the immunoglobulin A protease-like family of proteins. Infect. Immun. 65:4606-4614.

  35. Reeves, S. A., A. G. Torres, & S. M. Payne. 2000. TonB is required for intracellular growth and virulence of Shigella dysenteriae. Infect. Immun. 68:6329-36.

  36. Robbins, J. B., C.-Y. Chu, & R. Schneerson. 1992. Hypothesis for vaccine development: protective immunity to enteric diseases caused by nontyphoidal salmonellae and shigellae may be conferred by serum IgG antibodies to the O-specific polysaccharide of their lipopolysaccharides. Clin. Infect. Dis. 15:346-361.

  37. Robin, G., Y. Keisari, R. Slepon, S. Ashkenazi, & D. Cohen. 1999. Quantitative analysis of IgG class and subclass and IgA serum response to Shigella sonnei and Shigella flexneri 2a polysaccharides following vaccination with Shigella conjugate vaccines. Vaccine 17:3109-3115.

  38. Rowe, B., & R. J. Gross. 1984. Facultatively anaerobic gram-negative rods., p. 423-426. In N. R. Krieg (ed.), Bergey’s manual of systematic bacteriology., vol. v. 1. Williams & Wilkins, Baltimore/London.

  39. Ryan, K. J., & S. Falkow. 1994. Enterobacteriaceae, p. 328-332. In K. J. Ryan (ed.), Medical Microbiology. An introduction to infectious diseases., 3rd ed. Appleton & Lange, Norwalk, Connecticut.

  40. Sansonetti, P. J. 2001. Microbes and microbial toxins: paradigms for microbial-mucosal interactions III. Shigellosis: from symptoms to molecular pathogenesis. Am. J. Physiol. Gastrointest. Liver Physiol. 280:G319-23.

  41. Sansonetti, P. J. 2001. Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella, making sense of prokaryote-eukaryote cross-talks. FEMS Microbiol. Rev. 25:3-14.

  42. Sansonetti, P. J., J. Arondel, M. Huerre, A. Harada, & K. Matsushima. 1999. Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. Infect. Immun. 67:1471-1480.

  43. Sansonetti, P. J., D. J. Kopecko, & S. B. Formal. 1982. Involvement of a plasmid in the invasive ability of Shigella flexneri. Infect. Immun. 35:852-860.

  44. Sansonetti, P. J., & A. Phalipon. 1999. M cells as ports of entry for enteroinvasive pathogens: mechanisms of interaction, consequences for the disease process. Semin. Immunol. 11:193-203.

  45. Tran Van Nhieu, G., A. Ben Ze’ev, & P. J. Sansonetti. 1997. Modulation of bacterial entry into epithelial cells by interaction between vinculin and the Shigella IpaA invasin. EMBO J. 16:2717-2729.

  46. Tran Van Nhieu, G., & P. J. Sansonetti. 1999. Mechanism of Shigella entry into epithelial cells. Curr. Opin. Microbiol. 2:51-55.

  47. Van den Bosch, L., P. A. Manning, & R. Morona. 1997. Regulation of O-antigen chain length is required for Shigella flexneri virulence. Mol. Microbiol. 23:765-775.

  48. Venkatesan, M. M., M. B. Goldberg, D. J. Rose, E. J. Grotbeck, V. Burland, & F. R. Blattner. 2001. Complete DNA sequence and analysis of the large virulence plasmid of Shigella flexneri. Infect. Immun. 69:3271-3285.

  49. Vokes, S. A., S. A. Reeves, A. G. Torres, & S. M. Payne. 1999. The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island. Mol. Microbiol. 33:63-73.

  50. Wei, J., M. B. Goldberg, V. Burland, M. M. Venkatesan, W. Deng, G. Fournier, G. F. Mayhew, G. r. Plunkett, D. J. Rose, A. Darling, B. Mau, N. T. Perna, S. M. Payne, L. J. Runyen-Janecky, S. Zhou, D. C. Schwartz, & F. R. Blattner. 2003. Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect. Immun. 71:2775-2786.

  51. Wyckoff, E. E., D. Duncan, A. G. Torres, M. Mills, K. Maase, & S. M. Payne. 1998. Structure of the Shigella dysenteriae haem transport locus and its phylogenetic distribution in enteric bacteria. Mol. Microbiol. 28:1139-1152.

  52. Zychlinsky, A., M. C. Prévost, & P. J. Sansonetti. 1992. Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167-169.

  53. Zychlinsky, A., & P. J. Sansonetti. 1997. Apoptosis as a proinflammatory event: what can we learn from bacteria-induced cell death? Trends Microbiol. 5:201-204.




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