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ISSN 2992-8036 (Electronic)
ISSN 2306-4102 (Print)
Órgano Oficial del Colegio Mexicano de Ortopedia y Traumatología

2001, Number 1

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Acta Ortop Mex 2001; 15 (1)

The immunological profile of traumatized patients

Ramírez-Almaraz JA, Sarmiento-Hernández AP, Rojas-Mejía JG, Albor-Olivera L, Jiménez STP, Alejandre SR

Language: Spanish
References: 19
Page: 5-12
PDF size: 62.98 Kb.


ABSTRACT

Accidents are one of the main causes of morbility and mortality in our country. Trauma patients frequently develop infections, atypical evolution and slow wound healing. These individuals are under trauma, anesthesia and relapsing surgery which suppress immune functions. Our hypothesis is that such patients develop immunodeficiency. To corroborate it, humoral response, complement, cellular response and phagocytosis were assessed in three groups of patients: head contusion, penetrating wound of thorax/belly and open fractures of long bones. Results show slight depletion of IgG, IgM and C3, with small rise of IgA in all three groups. For cell response, patients with more than one blood unit transfusion were excluded to avoid confusion factors. Results demonstrated generalized depletion of CD4, CD8 and NK lymphocytes that recovered later on. Phagocytosis shows mostly a depletion of cells with higher phagocytic capacity and rise of those with null phagocytic capacity. Current results support the idea that immune suppression is an important factor for the sub-normal evolution of traumatized patients and the discovery of altered phagocytosis is a new finding.


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