2007, Number 4
<< Back Next >>
Ann Hepatol 2007; 6 (4)
Paclitaxel coated-stent for early-onset thrombosis after liver transplantation
Reyes-Corona J, Gonzalez-Huezo MS, Zea-Medina MV, Zamora-Valdés D, Victoria-Campos JL, Mondragon-Sanchez RJ
Language: English
References: 14
Page: 272-275
PDF size: 286.62 Kb.
Text Extraction
Hepatic artery thrombosis (HAT) is the most common vascular complication of orthotopic liver transplantation (OLT) and constitutes a potential emergency during the postoperative period. Surgical revascularization and retransplantation are the treatments of choice for this condition. The aim of this report is to present long-term follow-up on survival and graft function of three patients with paclitaxel-coated hepatic artery stents placed percutaneously after early-onset HAT. Three patients developed early onset HAT after cadaveric-donor OLT in a tertiary care center in Mexico. These patients were treated percutaneously with balloon angioplasty and paclitaxel-coated stents. After 24 months or more of follow-up, 2 patients present total occlusion of the stent and one patient, intra-stent stenosis; interestingly, all patients have normal graft function and excellent quality of life. In conclusion, although balloon angioplasty and stent placement may be a therapeutic option for suitable patients with early-onset HAT after OLT, long-term patency is unlikely even with the use of paclitaxel-coated materials.
REFERENCES
Langnas AN, Marujo W, Stratta RJ, Wood RP, Shaw BW, Jr. Vascular complications after orthotopic liver transplantation. Am J Surg 1991; 161: 76-82; discussion -3.
Pastacaldi S, Teixeira R, Montalto P, Rolles K, Burroughs AK. Hepatic artery thrombosis after orthotopic liver transplantation: a review of nonsurgical causes. Liver Transpl 2001; 7: 75-81.
Pinna AD, Smith CV, Furukawa H, Starzl TE, Fung JJ. Urgent revascularization of liver allografts after early hepatic artery thrombosis. Transplantation 1996; 62: 1584-7.
Vorwerk D, Gunther RW, Klever P, Riesener KP, Schumpelick V. Angioplasty and stent placement for treatment of hepatic artery thrombosis following liver transplantation. J Vasc Interv Radiol 1994; 5: 309-11; discussion 12-4.
Cotroneo AR, Di Stasi C, Cina A, et al. Stent placement in four patients with hepatic artery stenosis or thrombosis after liver transplantation. J Vasc Interv Radiol 2002; 13: 619-23.
Boyvat F, Aytekin C, Karakayali H, et al. Stent placement in pediatric patients with hepatic artery stenosis or thrombosis after liver transplantation. Transplant Proc 2006; 38: 3656-60.
Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973; 60: 646-9.
Mueller AR, Platz KP, Kremer B. Early postoperative complications following liver transplantation. Best Pract Res Clin Gastroenterol 2004; 18: 881-900.
Tamsel S, Demirpolat G, Killi R, et al. Vascular complications after liver transplantation: evaluation with Doppler US. Abdom Imaging 2007; 32: 339-47.
Mondragon RS, Karani JB, Heaton ND, et al. The use of percutaneous transluminal angioplasty in hepatic artery stenosis after transplantation. Transplantation 1994; 57: 228-31.
Abad J, Hidalgo EG, Cantarero JM, et al. Hepatic artery anastomotic stenosis after transplantation: treatment with percutaneous transluminal angioplasty. Radiology 1989; 171: 661-2.
Vivarelli M, La Barba G, Cucchetti A, et al. Can antiplatelet prophylaxis reduce the incidence of hepatic artery thrombosis after liver transplantation? Liver Transpl 2007; 13: 651-4.
Ueno T, Jones G, Martin A, et al. Clinical outcomes from hepatic artery stenting in liver transplantation. Liver Transpl 2006; 12: 422-7.
Drachman DE, Edelman ER, Seifert P, et al. Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months. J Am Coll Cardiol 2000; 36: 2325-32.