Caballero-Caballero R, Hernández-Rivera EG, López-Karpovitch JX

Language: Spanish
References: 25
Page: 393-397
PDF size: 119.08 Kb.

ABSTRACT

Background. Ocular lymphomas and ocular adnexae lymphomas (OL and OAL) constitute 7-8% of all extranodal lymphomas.
Objective. Describe the clinical, morphologic and immunophenotypic characteristics of OAL seen in our hospital.
Material and methods. Retrospective analysis of patient records with OL and OAL between July 1994 and July 2005. The following data was analyzed: Clinical presentation, therapy, treatment response, overall survival and disease free survival.
Results. Ten patients with OL and OAL were identified. Of these, 8 were women and 2 men. Median age was 50. Eight of 10 patients achieved complete remission, 6 of the 6 presenting MALT Lymphoma. Two patients with stage IV had refractory disease.
Conclusions. In our series 0.02% of lymphomas were OL and OAL of a total 498 LNH. MALT lymphomas appear at a more advanced age, sixty percent of the cases were MALT lymphomas and were diagnosed during their early stages. Patients were followed during 21 months, global survival was 100%, free illness survival had a mean of 868 days and a survival median of 442 days.

REFERENCES

1. Acero Peña A, Domingo Gordo B, Arrevalo Vrelasco L, Gómez García J, Martínez Montero JC Conjunctival Marginal zone lymphoma: clinical and pathological features. Archivos de la sociedad española de oftalmología 2000;7:1-4

2. Wotherspoon AC, Diss TC, Pan LX, Schmid C, Kerr-Muir MG, Lea SH. Primary Low-grade B-cell lymphoma of the conjunctiva: a muccosa-associated lymphoid tissue type lymphoma. Histopathology 1993;23:417-424.

3. Isaacson P, Wright D Malignant Lymphoma of mucosa associated lymphoid tissue, a distinctive type of B-cell lymphoma. Cancer 1983;52:1410-1416.

4. Myhre MJ, Isaacson PG. Primary B cell gastric lymphoma: a reassessment of its histogenesis. J Pathol 1987;152:1-11.

5. Addis BJ, Hyek E, Isaacson PG. Primary pulmonary lymphoma: a reappraisal of its histogenesis and its relation ship to pseudolymphoma and lymphoid interstitial pneumonia. Histopathology 1988;13:1-12.

6. Isaacson PG, Wright DH. Extranodal malignant Lymphomas arising from mucosa associated lymphoid tissue. Cancer 1984;53:2515-2524.

7. Isaacson PG. Lymphomas of mucosa-associated lymphoid tissue MALT. Histopathology 1990;15:617-619.

8. Freeman C, Berg JW, Cutler SJ. Ocurrence and prognosis of extranodal lymphomas. Cancer 1972;29:252-260.

9. Peterson K, Gordon K, Heinemann M, Deangelis L. The clinical spectrum of ocular lymphoma. Cancer 1993;72:843-849.

10. Whit Cup SM, Desmet MD, Rubin BI, Palestine AG, Martin BF, Burnier M, et al. Intraocular lymphoma. Clinical and histopathologic diagnosis. Ophthalmology 1993;100:1399-406.

11. Rankin GA, Jakobiec FA, Hidayat AA. Intraocular lymphoproliferations simulating uveitis. Principles and practice of ophthalmology. Philadelphia: 1994;524-548.

12. Freeman LM, Schachat AP, Knox DL, Michels RG, Green WR. Clinical features. Laboratory investigations and survival in ocular reticulum cell sarcoma. Ophthalmology 1987;94:1631-1639.

13. Fung CY, Tarbell NJ, Lucarelli MJ, Goldberg SI, Lingood RM, Harris NL, Ferry JA. Ocular Adnexae Lymphoma: clinical behaviour of distinct world health organization classification subtypes. Int J Radiat Oncol Biol Phys 2003;57:1382-1391.

14. Looi A, Gascogne RD, Chhanabhai M, Connors JM, Rootman J, White VA. Mantle cell lymphoma in the ocular adnexae region. Opthalmology 2005;112:114-119.

15. Non Hodgkin´s Lymphoma Pathologic Classification Project. National Cancer Institute sponsored study of classifications of non Hodgkin´s lymphomas. Abstract and description of a working formulation for clinical usage. Cancer 1982;49:2112.

16. Harris NL, Jaffe ES, Stein H, A revised European-American classification of lymphoid neoplasm: A proposal from the international Lymphoma Study Group. Blood 1994;84:1361-1392.

17. Jaffe E, Harris N, Stein H. WHO classification: Tumours of haematopoietic and lymphoid tissues. In: World Health Organization Classification of tumours series. Lyon: IARC Press; 2001

18. Isaacson PG, Spencer J. malignant lymphoma of mucosa-associated lymphoid tissue. Histopathology 1987;11:445-462.

19. Luppi M, Longo, Ferrari MG, Ferrara L, Marasca R, Barozzi P. et al. Additional neoplasm and HCV infection in low-grade lymphoma of lymphoma of MALT type. Br J Haematol 1996;94:373-375.

20. Ascoli V, Lo Coco F, Artini M, Levrero M, Martelli M, Negro F. Extranodal lymphomas associated with hepatitis C virus infection. Am J Clin Pathol 1998;109:600-609.

21. Stansfeld A, Diebolod J, Noel H, Kapanci Y, Rilke F, Kelenyile, et al. Updated Kiel classification for lymphoma. Lancet 1988;1:292.

22. Auw-Haedrich C. Coupland SE. Kapp A. Schmitt-Graff A, Buchen R, Witschel H. Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American lymphoma. Br J Ophthalmol 2001;85:64-69.

23. Cahill M. Barnes C, Moriarty P. Kennedy S. Ocular adnexal lymphomacomparison of MALT lymphoma with other histological types. Br J Ophthalmol 1999;83:742-747.

24. Uta Schick, Oliver Lermer, Renate Unsold, Werner Hassler Treatment of primary orbital lymphomas. Eur J Haematol 2004;72:186-192.

25. Suarez F, Lortholary O, Hermine O, Lecuit M. Infection-associated lymphomas derived from marginal zone B cells: a model of antigen driven lymphoproliferations. Blood 2006;107:3034-3044.