Suárez MJJ

Language: English
References: 9
Page: 58-59
PDF size: 27.87 Kb.

Text Extraction

An interaction between hepatitis C and the consumption of alcohol was suspected before the discovery of the hepatitis C virus (HCV) in 1989. Alcohol and HCV both cause liver injury. Although it is known that alcohol consumption is associated with apoptosis, oxidative stress, immune dysfunction (lower activities of cytotoxic T cells and helper T cells and decreased cytokine expression), increased HCV viral load, and greater numbers of HCV quasispecies, the mechanism of the interaction between alcohol and HCV is unknown.

REFERENCES

1. National Institutes of Health Consensus Development Conference statement: management of hepatitis C: 2002. Hepatology 2002; 36: S3-S20.

2. Morgan RT, et al. Hepatitis C and alcohol: fundamental and translational research directions. Alcohol Clin Exp Res 2003; 27(4): 726-31.

3. Rigamonti C, et al. Moderate alcohol consumption increases oxidative stress in patients with chronic hepatitis C. Hepatology 2003; 38(1): 42-9.

4. Schiff E, Ozden N. Hepatitis C and alcohol. Alcohol Research & Health 2003; 27(3): 232-9.

5. Sun CA, Wu DM, Lin CC, et al. Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in Taiwan. Am J Epidemiol 2003; 157: 674-82.

6. Monto A, Patel K, Bostrom A, et al. Risks of a range of alcohol intake on hepatitis C-related fibrosis. Hepatology 2004; 39: 826-34.

7. Monto A. Alcohol y Hepatitis C: Implicaciones en la progresión de la enfermedad y el treatment. Current Hepatitis Reports (edición en español) 2004; 1: 61-8.

8. Safdar K, Schiff E. Alcohol and hepatitis C. Semin Liv Dis 2004; 24(3): 305-15.

9. Wheeler M. Ethanol and HCV-induced cytotoxicity: the perfect storm. Gastroenterology 2005; 128(1): 232-4.