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Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2006, Number 3

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Rev Salud Publica Nutr 2006; 7 (3)

Nutrientes antioxidantes como agentes preventivos de cáncer, una revisión

López-Rodríguez G

Language: Spanish
References: 83
Page:
PDF size: 76.07 Kb.


ABSTRACT

The production of free radicals (FR) and the formation of reactive oxygen species (ROS) are an inherent part of metabolism. Moreover, these mechanisms are necessary to maintain vital functions. However, a lack of equilibrium between the production of ROS and the antioxidant condition of an undamaged cell causes oxidative stress (OS). The endogenous damage to DNA is the main cause of aging and degenerative diseases such as cancer. Once the cell is began, it continues and becomes malignant; then, the cell shows an incontrollable growth that distinguishes to neoplasia. Damage to ROS causes oxidation which is the greatest factor of risk in the carcinogen process. The effect of antioxidant nutrients has been evaluated in the three stages of cancer: beginning promotion, and progression. The efficacy of vitamins C, E, and Beta-carotene in the carcinogen process is proved in some review works, where it is showed that these nutrients have function in the elimination of carcinogens, inhibition of pre-carcinogens and reparation of DNA damage. This has caused the use of multiple antioxidant micronutrients as preventive agents, which have been used isolated or combined during short time and even long time. Although, many investigations have been done on this subject, it is not clear the specific effect of antioxidant’s use and the effective dose to prevent a beginning process of cancer by age groups have not been established.


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