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Órgano Oficial de la Asociación Mexicana de Hepatología

2006, Number 3

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Ann Hepatol 2006; 5 (3)

Liver disease during pregnancy: acute viral hepatitis

Sookoian S

Language: English
References: 50
Page: 231-236
PDF size: 89.16 Kb.


Text Extraction

Acute viral hepatitis is the most common cause of jaundice in pregnancy. The course of most viral hepatitis infections (e.g., hepatitis A, B, C and D) is unaffected by pregnancy, however, a more severe course of viral hepatitis in pregnancy has been observed in patients with hepatitis E. Notwithstanding, opinions differ over the maternal and fetal outcome of pregnancy associated with viral hepatitis. While some authors reported that acute viral hepatitis carries a high risk for both mother and fetus others conclude that non-fulminant viral hepatitis did not influence the course of pregnancy or fetal well-being. Rate of transmission of the virus during pregnancy depends on the virus. For instance, intra-utero transmission of hepatitis A virus is very rare, but perinatal transmission could occur. Conversely sixty percent of pregnant women who acquire acute HBV infections at or near delivery will transmit the HBV virus to their offspring and mother to child transmission of hepatitis E virus infection was established between 33.3 and 50%. Breast-feeding is not contra-indicated in women infected with the hepatitis A, E or C. However, for acute hepatitis B, with appropriate immunoprophylaxis, including hepatitis B immune globulin and hepatitis B vaccine, breast-feeding of infants of HBV infected mother’s poses no additional risk for the transmission of the hepatitis B virus. Finally, whether live or inactivated vaccines are used, vaccination of pregnant women should be considered on the basis of risks versus benefits. Pregnant women who think they may have been exposed to hepatitis B may be given and hepatitis B immunoglobulin (ideally within 72 hours of exposure), as well as the hepatitis B vaccine.


REFERENCES

  1. Riely CA. Hepatic disease in pregnancy. Am J Med 1994; 17; 96(1A): 18S-22S.

  2. Mishra L, Seeff LB. Viral hepatitis, A though E, complicating pregnancy. Gastroenterol Clin North Am 1992; 21(4): 873-887.

  3. Medhat A, el-Sharkawy MM, Shaaban MM, Makhlouf MM, Ghaneima SE. Acute viral hepatitis in pregnancy. Int J Gynaecol Obstet 1993; 40(1): 25-31.

  4. Khuroo MS, Duermeyer W, Zargar SA, Ahanger MA, Shah MA. Acute sporadic non-A, non-B hepatitis in India. Am J Epidemiol 1983; 118(3): 360-364.

  5. Hunt CM, Sharara AI. Liver disease in pregnancy. Am Fam Physician 1999; 15; 59(4): 829-836.

  6. Leikin E, Lysikiewicz A, Garry D, Tejani N. Intrauterine transmission of hepatitis A virus. Obstet Gynecol 1996; 88(4 Pt 2): 690-691.

  7. Duff P. Hepatitis in pregnancy. Semin Perinatol 1998; 22(4): 277-283.

  8. Duff P. Perinatal infectious disease. Introduction. Semin Perinatol 1998; 22(4): 241.

  9. Erkan T, Kutlu T, Cullu F, Tumay GT. A case of vertical transmission of hepatitis A virus infection. Acta Paediatr 1998; 87(9): 1008-1009.

  10. Renge RL, Dani VS, Chitambar SD, Arankalle VA. Vertical transmission of hepatitis A. Indian J Pediatr 2002; 69(6): 535-536.

  11. Elinav E, Ben-Dov IZ, Shapira Y, Daudi N, Adler R, Shouval D, et al. Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. Gastroenterology 2006; 130(4): 1129-1134.

  12. McDuffie RS, Jr., Bader T. Fetal meconium peritonitis after maternal hepatitis A. Am J Obstet Gynecol 1999; 180(4): 1031-1032.

  13. Gall SA. Maternal immunization. Obstet Gynecol Clin North Am 2003; 30(4): 623-636.

  14. Atkinson WL, Pickering LK, Schwartz B, Weniger BG, Iskander JK, Watson JC. General recommendations on immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP) and the American Academy of Family Physicians (AAFP). MMWR Recomm Rep 2002; 51(RR-2): 1-35.

  15. Letson GW, Shapiro CN, Kuehn D, Gardea C, Welty TK, Krause DS, et al. Effect of maternal antibody on immunogenicity of hepatitis A vaccine in infants. J Pediatr 2004; 144(3): 327-332.

  16. De SA, Avanzini MA, Terulla V, Zucca S, Polatti F, Belloni C. Decline of maternal hepatitis A virus antibody levels in infants. Acta Paediatr 2002; 91(8): 882-884.

  17. Breastfeeding and the use of human milk. American Academy of Pediatrics. Work Group on Breastfeeding. Pediatrics 1997; 100(6): 1035-1039.

  18. Levy M, Koren G. Hepatitis B vaccine in pregnancy: maternal and fetal safety. Am J Perinatol 1991; 8(3): 227-232.

  19. Xu DZ, Yan YP, Choi BC, Xu JQ, Men K, Zhang JX, et al. Risk factors and mechanism of transplacental transmission of hepatitis B virus: a case-control study. J Med Virol 2002; 67(1): 20-26.

  20. Hieber JP, Dalton D, Shorey J, Combes B. Hepatitis and pregnancy. J Pediatr 1977; 91(4): 545-549.

  21. Samuels P, Cohen AW. Pregnancies complicated by liver disease and liver dysfunction. Obstet Gynecol Clin North Am 1992; 19(4): 745-763.

  22. Mast EE, Margolis HS, Fiore AE, Brink EW, Goldstein ST, Wang SA, et al. A comprehensive immunization strategy to eliminate transmission of hepatitis B virus infection in the United States: recommendations of the Advisory Committee on Immunization Practice (ACIP) part 1: immunization of infants, children, and adolescents. MMWR Recomm Rep 2005; 54(RR-16): 1-31.

  23. Hill JB, Sheffield JS, Kim MJ, Alexander JM, Sercely B, Wendel GD. Risk of hepatitis B transmission in breast-fed infants of chronic hepatitis B carriers. Obstet Gynecol 2002; 99(6): 1049-1052.

  24. Linnemann CC, Jr., Goldberg S. Letter: HBAg in breast milk. Lancet 1974; 2(7873): 155.

  25. Boxall EH. Letter: Breast-feeding and hepatitis B. Lancet 1975; 2(7942): 979.

  26. Pavel A, Tirsia E, Maior E, Cristea A. Detrimental effects of hepatitis B virus infection on the development of the product of conception. Virologie 1983; 34(1): 35-40.

  27. Smithwick EM, Pascual E, Go SC. Hepatitis-associated antigen: a possible relationship to premature delivery. J Pediatr 1972; 81(3): 537-540.

  28. Davies G, Wilson RD, Desilets V, Reid GJ, Shaw D, Summers A, et al. Amniocentesis and women with hepatitis B, hepatitis C, or human immunodeficiency virus. J Obstet Gynaecol Can 2003; 25(2): 145-152.

  29. Resti M, Azzari C, Mannelli F, Moriondo M, Novembre E, de MM, et al. Mother to child transmission of hepatitis C virus: prospective study of risk factors and timing of infection in children born to women seronegative for HIV-1. Tuscany Study Group on Hepatitis C Virus Infection. BMJ 1998; 317(7156): 437-441.

  30. Conte D, Fraquelli M, Prati D, Colucci A, Minola E. Prevalence and clinical course of chronic hepatitis C virus (HCV) infection and rate of HCV vertical transmission in a cohort of 15,250 pregnant women. Hepatology 2000; 31(3): 751-755.

  31. Gonzalez F, Medam-Djomo MA, Lucidarme D, Khalil A, Decoster A, Houze de LD, et al. Acute hepatitis C during the third trimester of pregnancy. Gastroenterol Clin Biol 2006; 30(5): 786-789.

  32. Flichman D, Cello J, Castano G, Campos R, Sookoian S. In vivo down regulation of HIV replication after hepatitis C superinfection. Medicina (B Aires) 1999; 59(4): 364-366.

  33. Hardikar W, Elliott EJ, Jones CA. The silent infection: should we be testing for perinatal hepatitis C and, if so, how? Med J Aust 2006; 184(2): 54-55.

  34. Soulie JC. [Hepatitis C and pregnancy: is it necessary to screen for the risk of vertical transmission?]. J Gynecol Obstet Biol Reprod (Paris) 1993; 22(6): 631-634.

  35. Burns DN, Minkoff H. Hepatitis C: screening in pregnancy. Obstet Gynecol 1999; 94(6): 1044-1048.

  36. Thung SF, Grobman WA. The cost-effectiveness of routine antenatal screening for maternal herpes simplex virus-1 and -2 antibodies. Am J Obstet Gynecol 2005; 192(2): 483-488.

  37. Kumar RM, Shahul S. Role of breast-feeding in transmission of hepatitis C virus to infants of HCV-infected mothers. J Hepatol 1998; 29(2): 191-197.

  38. Lin HH, Kao JH, Hsu HY, Ni YH, Chang MH, Huang SC, et al. Absence of infection in breast-fed infants born to hepatitis C virus-infected mothers. J Pediatr 1995; 126(4): 589-591.

  39. Krawczynski K, Aggarwal R, Kamili S. Hepatitis E. Infect Dis Clin North Am 2000; 14(3): 669-687.

  40. Kumar A, Beniwal M, Kar P, Sharma JB, Murthy NS. Hepatitis E in pregnancy. Int J Gynaecol Obstet 2004; 85(3): 240-244.

  41. Pal R, Aggarwal R, Naik SR, Das V, Das S, Naik S. Immunological alterations in pregnant women with acute hepatitis E. J Gastroenterol Hepatol 2005; 20(7): 1094-1101.

  42. Smith JL. A review of hepatitis E virus. J Food Prot 2001; 64(4): 572-586.

  43. Khuroo MS, Kamili S, Jameel S. Vertical transmission of hepatitis E virus. Lancet 1995; 345(8956): 1025-1026.

  44. Singh S, Mohanty A, Joshi YK, Deka D, Mohanty S, Panda SK. Mother-to-child transmission of hepatitis E virus infection. Indian J Pediatr 2003; 70(1): 37-39.

  45. Chibber RM, Usmani MA, Al-Sibai MH. Should HEV infected mothers breast feed? Arch Gynecol Obstet 2004; 270(1): 15-20.

  46. Hamid SS, Jafri SM, Khan H, Shah H, Abbas Z, Fields H. Fulminant hepatic failure in pregnant women: acute fatty liver or acute viral hepatitis? J Hepatol 1996; 25(1): 20-27.

  47. Jaiswal SP, Jain AK, Naik G, Soni N, Chitnis DS. Viral hepatitis during pregnancy. Int J Gynaecol Obstet 2001; 72(2): 103-108.

  48. Li XM, Ma L, Yang YB, Shi ZJ, Zhou SS. Clinical characteristics of fulminant hepatitis in pregnancy. World J Gastroenterol 2005; 11(29): 4600-4603.

  49. Hamilton MI, Alcock R, Magos L, Mallett S, Rolles K, Burroughs AK. Liver transplantation during pregnancy. Transplant Proc 1993; 25(5): 2967-2968.

  50. Laifer SA, Darby MJ, Scantlebury VP, Harger JH, Caritis SN. Pregnancy and liver transplantation. Obstet Gynecol 1990; 76(6): 1083-1088.




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