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Órgano Oficial de la Asociación Mexicana de Hepatología

2006, Number 3

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Ann Hepatol 2006; 5 (3)

Pregnancy after liver transplantation

Rinella ME

Language: English
References: 34
Page: 212-215
PDF size: 74.64 Kb.


Text Extraction

Although the transplant community has begun to gather experience in pregnancy after liver transplant, much remains to be learned about the effects of pregnancy on mother and child. Most women with end stage liver disease have amenorrhea or are unable to conceive due to medical complications. Liver transplantation offers such patients the opportunity to have children. Since libido and fertility can return fairly rapidly, it is important to discuss birth control in the early post transplant period. It is recommended that pregnancy be delayed for 1 and preferably 2 years post-transplant as pregnancies within the first year are associated with higher rates of premature birth and cellular rejection. The current evidence suggests that pregnancy is safe after transplant, however it requires close follow-up by a team of experienced physicians.


REFERENCES

  1. Cundy TF, O’Grady JG, Williams R. Recovery of menstruation and pregnancy after liver transplantation. Gut 1990; 31(3): 337-8.

  2. Walcott WO, Derick DE, Jolley JJ, Snyder DL. Successful pregnancy in a liver transplant patient. Am J Obstet Gynecol 1978; 132(3): 340-1.

  3. Armenti VT. Pregnancy after liver transplantation. Liver Transpl 2006; 12(7): 1037-9.

  4. Scantlebury V, Gordon R, Tzakis A, et al. Childbearing after liver transplantation. Transplantation 1990; 49(2): 317-21.

  5. Riely CA. Contraception and pregnancy after liver transplantation. Liver Transpl 2001; 7(11 Suppl 1): S74-6.

  6. Brown KA, Lucey MR. Liver transplantation restores female reproductive endocrine function. Hepatology 1991; 13(6): 1255-7.

  7. Armenti VT, Radomski JS, Moritz MJ, Philips LZ, McGrory CH, Coscia LA. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl 2000: 123-34.

  8. Christopher V, Al-Chalabi T, Richardson PD, et al. Pregnancy outcome after liver transplantation: a single-center experience of 71 pregnancies in 45 recipients. Liver Transpl 2006; 12(7): 1138-43.

  9. Hou S. Pregnancy in chronic renal insufficiency and end-stage renal disease. Am J Kidney Dis 1999; 33(2): 235-52.

  10. Stratta P, Canavese C, Giacchino F, Mesiano P, Quaglia M, Rossetti M. Pregnancy in kidney transplantation: satisfactory outcomes and harsh realities. J Nephrol 2003; 16(6): 792-806.

  11. Laifer SA, Guido RS. Reproductive function and outcome of pregnancy after liver transplantation in women. Mayo Clin Proc 1995; 70(4): 388-94.

  12. Morales JM, Hernandez Poblete G, Andres A, Prieto C, Hernandez E, Rodicio JL. Uric acid handling, pregnancy and cyclosporin in renal transplant women. Nephron 1990; 56(1): 97-8.

  13. Levine RJ, Karumanchi SA. Circulating angiogenic factors in preeclampsia. Clin Obstet Gynecol 2005; 48(2): 372-86.

  14. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol 2000; 183(1): S1-S22.

  15. Podymow T, August P, Umans JG. Antihypertensive therapy in pregnancy. Semin Nephrol 2004; 24(6): 616-25.

  16. Patapis P, Irani S, Mirza DF, et al. Outcome of graft function and pregnancy following liver transplantation. Transplant Proc 1997; 29(1-2): 1565-6.

  17. Jain AB, Reyes J, Marcos A, et al. Pregnancy after liver transplantation with tacrolimus immunosuppression: a single center’s experience update at 13 years. Transplantation 2003; 76(5): 827-32.

  18. Jain A, Venkataramanan R, Fung JJ, et al. Pregnancy after liver transplantation under tacrolimus. Transplantation 1997; 64(4): 559-65.

  19. Armenti VT, Herrine SK, Radomski JS, Moritz MJ. Pregnancy after liver transplantation. Liver Transpl 2000; 6(6): 671-85.

  20. Tendron A, Gouyon JB, Decramer S. In utero exposure to immunosuppressive drugs: experimental and clinical studies. Pediatr Nephrol 2002; 17(2): 121-30.

  21. Pergola PE, Kancharla A, Riley DJ. Kidney transplantation during the first trimester of pregnancy: immunosuppression with mycophenolate mofetil, tacrolimus, and prednisone. Transplantation 2001; 71(7): 994-7.

  22. Le Ray C, Coulomb A, Elefant E, Frydman R, Audibert F. Mycophenolate mofetil in pregnancy after renal transplantation: a case of major fetal malformations. Obstet Gynecol 2004; 103(5 Pt 2): 1091-4.

  23. European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.10. Pregnancy in renal transplant recipients. Nephrol Dial Transplant 2002; 17 Suppl 4: 50-5.

  24. Jankowska I, Oldakowska-Jedynak U, Jabiry-Zieniewicz Z, et al. Absence of teratogenicity of sirolimus used during early pregnancy in a liver transplant recipient. Transplant Proc 2004; 36(10): 3232-3.

  25. Guardia O, Rial Mdel C, Casadei D. Pregnancy under sirolimus-based immunosuppression. Transplantation 2006; 81(4): 636.

  26. Armenti VT, Ahlswede KM, Ahlswede BA, et al. Variables affecting birthweight and graft survival in 197 pregnancies in cyclosporinetreated female kidney transplant recipients. Transplantation 1995; 59(4): 476-9.

  27. Jain AB, Shapiro R, Scantlebury VP, et al. Pregnancy after kidney and kidney-pancreas transplantation under tacrolimus: a single center’s experience. Transplantation 2004; 77(6): 897-902.

  28. Thomas AG, Burrows L, Knight R, Panico M, Lapinski R, Lockwood CJ. The effect of pregnancy on cyclosporine levels in renal allograft patients. Obstet Gynecol 1997; 90(6): 916-9.

  29. Miniero R, Tardivo I, Curtoni ES, et al. Pregnancy after renal transplantation in Italian patients: focus on fetal outcome. J Nephrol 2002; 15(6): 626-32.

  30. Armenti VT, Radomski JS, Moritz MJ, et al. Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation. Clin Transpl 2002: 121-30.

  31. Laifer SA, Abu-Elmagd K, Fung JJ. Hepatic transplantation during pregnancy and the puerperium. J Matern Fetal Med 1997; 6(1): 40-4.

  32. Laifer SA, Darby MJ, Scantlebury VP, Harger JH, Caritis SN. Pregnancy and liver transplantation. Obstet Gynecol 1990; 76(6): 1083-8.

  33. Laifer SA, Ehrlich GD, Huff DS, Balsan MJ, Scantlebury VP. Congenital cytomegalovirus infection in offspring of liver transplant recipients. Clin Infect Dis 1995; 20(1): 52-5.

  34. McKay DB, Josephson MA, Armenti VT, et al. Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation. Am J Transplant 2005; 5(7): 1592-9.




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