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2006, Number 3

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Ann Hepatol 2006; 5 (3)

Choroidal neovascularization with interferon associated retinopathy: Case report and review of literature

Bazarah SM, Ritenour R, Patel ST, Hirsch G, Peltekian KM, Cruess AF

Language: English
References: 21
Page: 172-176
PDF size: 173.24 Kb.


Text Extraction

We report a case of new interferon-associated ocular complication during treatment with combination of pegylated interferon plus ribavirin for chronic hepatitis C infection. Our patient developed choroidal neovascularization in addition to the classic interferon associated retinopathy. Choroidal neovascularization has not been reported before in association with interferon induced retinopathy. We describe our management to control the ocular symptoms and the retinal lesions with one year follow up. We also provide literature report on the natural history, the pathophysiology and the variable characteristics of interferon associated retinopathy versus hepatitis C related ophthalmopathy.


REFERENCES

  1. Fried MW. Side effects of therapy of hepatitis C and their management. Hepatology 2002; 36: S237-44.

  2. Willson RA. Visual side effects of pegylated interferon during therapy for chronic hepatitis C infection. J Clin Gastroenterol 2004; 38: 717-22.

  3. Sherman M, Bain V, Villeneuve JP, Myers RP, Cooper C, Martin S, Lowe C. The management of chronic viral hepatitis: a Canadian consensus conference 2004. Can J Gastroenterol 2004; 18: 715-28.

  4. d’Alteroche L, Majzoub S, Lecuyer AI, Delplace MP, Bacq Y. Ophthalmologic side effects during alpha-interferon therapy for viral hepatitis. J Hepatol 2006; 44: 56-61.

  5. Hayasaka S, Nagaki Y, Matsumoto M, Sato S. Interferon associated retinopathy. Br J Ophthalmol 1998; 82: 323-5.

  6. Guyer DR, Tiedeman J, Yannuzzi LA, Slakter JS, Parke D, Kelley J, Tang RA, Marmor M, Abrams G, Miller JW, et al. Interferon-associated retinopathy. Arch Ophthalmol 1993; 111: 350-6.

  7. Nishiwaki H, Ogura Y, Miyamoto K, Matsuda N, Honda Y. Interferon alfa induces leukocyte capillary trapping in rat retinal microcirculation. Arch Ophthalmol 1996; 114: 726-30.

  8. Sugano S, Suzuki T, Watanabe M, Ohe K, Ishii K, Okajima T. Retinal complications and plasma C5a levels during interferon alpha therapy for chronic hepatitis C. Am J Gastroenterol 1998; 93: 2441-4.

  9. Hayasaka S, Fujii M, Yamamoto Y, Noda S, Kurome H, Sasaki M. Retinopathy and subconjunctival haemorrhage in patients with chronic viral hepatitis receiving interferon alfa. Br J Ophthalmol 1995; 79: 150-2.

  10. Abe T, Nakajima A, Satoh N, Koizumi T, Sakuragi S, Ono T, Komatsu M, Masamune O. Clinical characteristics of hepatitis C virus-associated retinopathy. Jpn J Ophthalmol 1995; 39: 411-9.

  11. Tokai R, Ikeda T, Miyaura T, Sato K. Interferon-associated retinopathy and cystoid macular edema. Arch Ophthalmol 2001; 119 : 1077-9.

  12. Zegans ME, Anninger W, Chapman C, Gordon SR. Ocular manifestations of hepatitis C virus infection. Curr Opin Ophthalmol 2002; 13: 423-7.

  13. Isaac A, Lindenmann J. Virus interference. I. The interferon. Proc R Soc Lond B Biol Sci 1957; 147: 258-67.

  14. Friesel R, Komoriya A, Maciag T. Inhibition of endothelial cell proliferation by gamma-interferon. J Cell Biol 1987; 104: 689-96.

  15. Sundmacher R, Cantell K, Skoda R, Hallermann C, Neumann-Haefelin D. Human leukocyte and fibroblast interferon in a combination therapy of dendritic keratitis. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1978; 208: 229-33.

  16. Fung WE. Interferon alpha 2a for treatment of age-related macular degeneration. Am J Ophthalmol 1991; 112: 349-50.

  17. Gillies M, Francis I, McCluskey P, Wakefield D. Local interferon alfa-2b for ocular cicatricial pemphigoid. Br J Ophthalmol 1996; 80: 927.

  18. Gillies MC, Brooks AM, Young S, Gillies B, Simpson JM, Goldberg I. A randomized phase II trial of interferon-alpha2b versus 5-fluorouracil after trabeculectomy. Aust N Z J Ophthalmol 1999; 27: 37-44.

  19. Ikebe T, Nakatsuka K, Goto M, Sakai Y, Kageyama S. A case of retinopathy induced by intravenous administration of interferon. Folia Ophthalmol Jpn (Ganka-Kiyo) 1990; 41: 2291-6.

  20. Jain K, Lam WC, Waheeb S, Thai Q, Heathcote J. Retinopathy in chronic hepatitis C patients during interferon treatment with ribavirin. Br J Ophthalmol 2001; 85: 1171-1173 .

  21. Cuthbertson FM, Davies M , McKibbin M. Is screening for interferon retinopathy in hepatitis C justified? Br J Ophthalmol 2004; 88: 1518-1520.




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