2000, Number 4
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Acta Ortop Mex 2000; 14 (4)
The employment of coralline and collagen-gentamicin in bone healin. Report of 3 cases
Solís GJ, Suárez EV, Herrera ZG
Language: Spanish
References: 15
Page: 351-353
PDF size: 31.54 Kb.
ABSTRACT
One of the synthetic materials that have been developed for bony regeneration is the coralline (pro-osteon 500) that has similar properties to the spongial bone, it is biocompatible and bone-conductive, having an osteo-integration index of 55% measured hystometrically. The Garacoll is a sponge of collagen that has demonstrated to be effective as preventive of infections based on a system of local liberation of gentamicin. So much the pro-osteon 500 and the combination of collagen with gentamicin were used in three patients, the first of them with atrophic pseudoarthrosis, the second with bony loss because of fracture and the last one with poor bone quality. It was observed a clinical and radiological integration of the coralline and the Garacoll. We did a cost-benefit analysis and we present the results.
REFERENCES
Alper G, Bemick S, Yazdi M, Nimmi M. Osteogenesis in bone defects in rats: the effects of hydroxyapatite and demineralized bone matrix. Am J Med Sci 1989; (7): 296-371.
Benfer J, Struck H. Promotion of fracture healing by local collagen application. Otch Med 2 W sch. R 1972; 97: 523-4.
Bucholz RW, Carlton A, Holmes R. Interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures. Clin Ortho Rel Res 1989; 240: 53-62.
Colchero F. Tratamiento integral del paciente con infección ósea. Editorial Trillas 1990.
Craig WA, Leggett J, Totsukak, Volgenman B. Key pharmacokinetic parameters of antibiotic efficacy in experimental animal infections. J Drug Dev 1988; 1(53): 7-15.
Dutton JJ. Coralline hydroxyapatite as an ocular implant. Ophthalmology 1991; 98(3): 370.
Eckstein T, Steveling H, Buchner E. Initial clinical experience with gentamicin. Deutsche Zeitschift for Mund Kie Fer und Gesichts Chiruggie 1989: 13-4
Hasselbach Ch. The management of infected THP. Revisions using gentamicin loded collagen sponges. 26 Congress of the International College of Surgeons. Milán, Italy 1988: 3-9.
Kuster H. Bone regeneration after fibrin spongiosa and collagen spongiosa implantation, an animal experience comparison Hackenbroch Refior Jager Thieme Verlag Stuttgart 1982: 204.
Letsch and cols. Garacoll-Implante. Archivo interno del laboratorio Schering-Plough. División Essex-Pharma 1996
Ohgushi H, Okumura M. Osteogenic capacity of rat and human marrow cells in porous ceramic. Experiments in athymic (nude) mice. Acta Orthop Scand (Denmark) 1990; 1(5): 431-4
Okumura M, Ohgushi HS, Shors EC. Primary Bone Formation in porous hydroxyapatite Ceramic: A light and scanning electron microscopy study. Cells and materials, 1(1) Interpore 1991; 91-4: 29-34.
Ripamonti U. The morphogenesis of bone in replicas of porous hydroxyapatite obtained from conversion of calcium carbonate exoskeletons of coral. The Bone Joint Surg 1991: 692-703.
Rushton N. Surgery, Science & Sepsis. Simposio, “Innovaciones para la prevención de infecciones quirúrgicas”. Barcelona, España 1996.
Usui Y, Zerwekh JE et al. Different effects of mechanical vibration on bone ingrowth into porous hydroxyapatite and fracture healing in a rabbit model. J Ortho Res 1989: 559-67.