Suárez EV, Lazcano MMA, Solís GJ

Language: Spanish
References: 12
Page: 331-334
PDF size: 35.20 Kb.

ABSTRACT

Bone infections in orthopedic surgery represent a serious problem, in consequence preventive parenteral antibiotic have been used, having the inconvenience that they arrive in little concentration to the surgical wound. Efforts to revert this fact are: the use of surgical cements containing this medications, continuous infusion systems and lately the collagen and gentamicin sponges; methods that take the antibiotic to the place of the wound in high concentrations. From June 1996 to September 1997, 80 patient with fluctuating ages from 6 to the 92 years, with a 68 year-old average were studied; they were 41 female patients and 39 male patients. With an averaged follow up of one year. They were performed 80 diverse orthopedic procedures where the sponge with gentamicin was used to help systemic antibiotics. We found that, until the moment of the present study, we do not have postoperative infections and that the urine levels of gentamicin in 36 patients did not reach toxic levels for this medication allowing its use of this type of sponges with gentamicin in patient with renal problems.

REFERENCES

1. Benfer J, Struck H. Promotion of fracture healing by local collagen application. Otch Med 2 W sch. R. 1972; 97: 523-524.

2. Colchero F. Tratamiento integral del paciente con infección ósea. Editorial Trillas 1990.

3. Craig WA, Leggett J, Totsukak, Volgenman B. Key pharmacokinetic parameters of antibiotic efficacy in experimental animal infections. J Drug Dev 1988; 81(53): 7-15.

4. Eckstein T, Steveling H, Buchner E. Initial clinical experience with gentamicin. Deutsche Zeitschift for Mund Kie Fer und Gesichts Chiruggie 1989: 13-4.

5. Guzmán VG, Soto GMT. Evaluación clínica del implante de colágeno-gentamicina en heridas quirúrgicas sucias.

6. Hasselbach Ch. The management of infected THP. Revisions using gentamicin loded collagen sponges. 26 Congress of the International College of Surgeons. Milán, Italy 1988: 3-9.

7. Kuster H. Bone regeneration after fibrin spongiosa and collagen spongiosa implantation, an animal experience comparison Hackenbroch Refior Jager Thieme Verlag Stuttgart 1982: 204.

8. Letsch and cols. Garacoll-Implante. Archivo interno del laboratorio Schering-Plough. División Essex-Pharma 1996.

9. Rushton N. Surgery, Science & Sepsis. Simposio. Inovaciones para la prevención de infecciones quirúrgicas. Barcelona, España Marzo 1996.

10. Scaglione F. Surgery, Science & Sepsis. Simposio, Inovaciones para la prevención de infecciones quirúrgicas. Barcelona, España. Marzo 1996.

11. Stemberger A. Surgery, Science & Sepsis. Simposio. Inovaciones para la prevención de infecciones quirúrgicas. Barcelona, España. Marzo 1996.

12. Tachdjian MO, Compare EL. Post-operative wound infection in orthopaedic surgery: evaluation of prophylactic antibiotics. J Int Col Surg 1957; 28-28: 797-805.