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ISSN 0188-9796 (Print)

2003, Number 1

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Rev Endocrinol Nutr 2003; 11 (1)

Incidence and risk factors for developed impaired glucose tolerance and diabetes mellitus type 2 in mexican people previously normoglycemic

Vázquez CC, Salinas OS, Moreno VK, Gómez DRA, Rosso JMM, Jiménez VM, Argüero SR

Language: Spanish
References: 22
Page: 28-33
PDF size: 80.37 Kb.


ABSTRACT

Obesity, age, sex and hyperinsulinemia are some of the risk factors involved in the natural history of diabetes mellitus type 2, they may be important for developing impaired glucose tolerance (IGT) and useful as targets for preventive therapy. We made a study in Mexican population, trying to know the percentage of subjects with normoglycaemia who eventually developed impaired glucose tolerance or diabetes mellitus type 2, and to know the factors. That contribute to its development. Material and methods: A cross-sectional analysis in 1998 from a longitudinal, prospective study ongoing at the Hospital de Cardiologia, CMN SXXI, including normotensive and hypertensive Mexican men and women was started in 1992 collecting anthropometric and metabolic data including age, sex, weight, height, body mass index (BMI), waist/hip ratio, glucose and insulin at 0, 60 and 120 minute during a 75 g oral glucose tolerance test (OGTT). Total cholesterol, triglycerides, cholesterol from high and low density lipoprotein and fibrinogen were also measured. For the statistical analysis means + standard deviation, of each group were calculated. All people in the study were classificated like hyperinsulinaemic (Fasting insulin > 15 µU/mL) or normoinsulinaemic (Fasting insulin < 15 µU/mL). In other study we demonstred that healthy people with normal glucose tolerance test and normal insulin action by glucose/insulin ratio >6, had fasting insulin levels of 8.7 ± 3.2 µU/ml and with two standard deviation (15.1 µU/mL) we asumed is the normal insulin level in fasting state. The developed between 1992-1998 for IGT or DM-2 was determinated and comparative analysis and odds ratio evaluation was made. Results: One hundred and eighty seven previously normoglycemic subjects were evaluated in 1998 repeating the same questionnaire and laboratory quantifications, 31 (16.5%) evolved to some degree of glucose intolerance according to a 75 g OGTT. 24 subjects developed IGT and 7 diabetes mellitus type 2 (DM-2). When logistic regression analysis (odds ratio) was used only age and body mass index gave a significant value of 1.46 (CI 95% 1.01-2.11) and 1.95 (CI 95% 1.10-3.46) respectively. 23 of the 31 patients (74%) had initial fasting insulin above 15 µU/mL. Conclusions: The follow-up by 6 years of 187 normoglycaemic people was show that 31 (16.5%) development some degree in the glucose metabolism, 24/187 (12.8%) IGT and 7/187 (3.7%) DM-2, with age and body mass index like predictive factors, and having 74% fasting insulinaemia more high.


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