Sung-W L, Wang X, Roy CN, Roy-Chowdhury J

Language: Spanish
References: 50
Page: 48-53
PDF size: 49.99 Kb.

Text Extraction

Over three decades of research in experimental animals and several clinical trials have brought us to the threshold of hepatocyte transplantation for the treatment of acute and chronic liver failure, and inherited metabolic disorders. However, more extensive clinical studies and routine clinical application are hampered by the shortage of good quality of donor cells. To overcome these hurdles, current research has focused on the search for alternatives to adult primary hepatocytes, such as liver cell progenitors, fetal hepatoblasts, embryonic, bone marrow or umbilical cord blood stem cells and conditionally immortalized hepatocytes. Cross-species hepatocyte transplantation is also being explored. It is hoped that ongoing research will permit the application of hepatocyte transplantation to the treatment of a wide array of liver diseases.

REFERENCES

1. United Network for Organ Sharing (http://www.unos.org).

2. Goldstein MJ, Salame E, Kapur S, Kinkhabwala M, LaPointe-Rudow D, Harren NPP, et al. Analysis of failure in living donor liver transplantation: differential outcomes in children and adults. World J Surg 2003, 27(3): 356-364.

3. Moshage HJ, Rijntjes PJ, Hafkenscheid JC, Roelofs HM, Yap SH. Primary culture of cryopreserved adult human hepatocytes on homologous extracellular matrix and the influence of monocytic products on albumin synthesis. J Hepatol 1988; 7: 34-44.

4. Jamal HZ, Weglarz TC, Sangren EP. Cryopreserved mouse hepatocytes retain regenerative capacity in vivo. Gastroenterology 2000; 118(2): 390-394.

5. Demetriou AA, Levenson SM, Novikoff PM, Novikoff AB, Roy Chowdhury N, Whiting J, et al. Survival, organization and function of microcarrier-attached hepatocytes transplanted in rats. Proc Natl Acad Sci USA 1986; 83: 7475-7479.

6. Kusano M, Mito M. Observations on the fine structure of long survived hepatocytes inoculated into rat spleen. Gastroenterology 1982; 82: 616-628.

7. Demetriou A, Levenson SM, Whiting J, Feldman D, Moscioni AD, Kram M, Roy Chowdhury N, Roy Chowdhury J. Replacement of hepatic functions in rats by transplantation of microcarrier-attached hepatocytes. Science 1986; 233: 1190-1192.

8. Gupta S, Rajvanshi P, Sokhi R, Slehria S, Yam A, Kerr A, et al. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium. Hepatology 1999; 29: 509-519.

9. Rhim JA, Sandgren EP, Palmiter RD, Brinster RL. Complete reconstitution of mouse liver with xenogeneic hepatocytes. Proc Natl Acad Sci USA 1995; 92: 4942-4946.

10. Overturf K, Al-Dhalimy M, Ou CN, Finegold M, Grompe M. Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes. Am J Pathol 1997; 151: 1273-1280.

11. Selden C, Calnan D, Morgan N, Wilcox H, Carr E, Hodgson HJ. Histidinemia in mice: a metabolic defect treated using a novel approach to hepatocellular transplantation. Hepatology 1995; 21: 1405-1412.

12. Sandhu JS, Petkov PM, Dabeva MD, Shafritz DA. Stem cell properties and repopulation of the rat liver by fetal liver epithelial progenitor cells. Am J Pathol 2001; 159: 1323-1334.

13. Fausto N, Campbell JS. The role of hepatocytes and oval cells in liver regeneration and repopulation. Mech Dev 2003; 120: 117-130.

14. Petersen BE, Bowen WC, Patrene KD, Mars WM, Sullivan AK, Murase N, et al. Bone marrow as a potential source of hepatic oval cells. Science 1999; 284: 1168-1170.

15. Thiese ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, et al. Liver from bone marrow in humans. Hepatology 2000; 32: 11-16.

16. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 2003; 422: 897-901.

17. Yamamoto H, Quinn G, Asari A, Yamanokuchi H, Teratani T, Terada M, et al. Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. Hepatology 2003; 37: 983-993.

18. Kakinuma S, Tanaka Y, Chinzei R, Watanabe M, Shimizu-Saito K, Har Y, et al. Human umbilical cord as a source of transplantable hepatic progenitor cells. Stem Cells 2003; 21: 217-227.

19. Roy Chowdhury J, Grossman M, Gupta S, Chowdhury NR, Baker Jr JR, Wilson JM. Long-term improvement of hypercholesterolemia after ex vivo gene therapy in LDLR-deficient rabbits. Science 1991; 254: 1802-1805.

20. Grossman M, Raper SE, Kozarsky K, Stein EA, Engelhardt JF, Muller D, et al. Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolemia. Nat Genet 1994, 6(4): 335-341.

21. Wege H, Le HT, Chui MS, Liu L, Wu J, Giri R, et al. Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential. Gastroenterology 2003; 124: 432-444.

22. Amicone L, Spagnoli FM, Spath G, Giordano S, Tommasini C, Bernardini S, et al. Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes. Eur Mol Biol Org J 1997; 16: 495-503.

23. Nakamura J, Okamoto T, Schumacher IK, Tabei I, Roy Chowdhury N, Roy Chowdhury J, et al. Treatment of surgically induced acute liver failure by transplantation of conditionally immortalized hepatocytes. Transplantation 1997; 63: 1541-1547.

24. Cai J, Ito M, Nagata H, Westerman KA, Lafleur D, Roy Chowdhury J, et al. Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes. Hepatology 2002; 36: 386-394.

25. Nagata H, Ito M, Cai J, Edge AS, Platt JL, Fox IJ. Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation. Gastroenterology 2003; 124: 422-431.

26. Gupta S, Roy Chowdhury J. Hepatocyte transplantation: back to the future. Hepatology 1992; 15(1): 156-162.

27. Arkadopoulos N, Chen SC, Khalili TM, Detry O, Hewitt WR, Lilja H, et al. Transplantation of hepatocytes for prevention of intracranial hypertension in pigs with ischemic liver failure. Cell Transplant 1998; 7: 357-363.

28. Braun KM, Degen JL, Sandgren E. Hepatocyte transplantation in a model of toxin-induced liver disease: variable therapeutic effect during replacement of damaged parenchyma by donor cells. Nat Med 2000; 6(3): 320-326.

29. Ribeiro J, Nordlinger B, Ballet F, Cynober L, Coudray-Lucas C, Baudrimont M, et al. Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacaval-shunted rats. Hepatology 1992; 15(1): 12-18.

30. Schumacher IK, Okamoto T, Kim BH, Chowdhury NR, Chowdhury JR, Fox IJ. Transplantation of conditionally immortalized hepatocytes to treat hepatic encephalopathy. Hepatology 1996; 24(2): 337-343.

31. Kobayashi N, Ito M, Nakamura J, Cai J, Gao C, Hammel JM, Fox IJ. Hepatocyte transplantation in rats with decompensated liver cirrhosis. Hepatology 2000; 31(4): 851-857.

32. Yoshida Y, Tokusashi Y, Lee GH, Ogawa K. Intrahepatic transplantation of normal hepatocytes prevents Wilson’s disease in Long-Evans cinnamon rats. Gastroenterology 1996; 111: 1654-1660.

33. Wilson JM, Roy Chowdhury N, Grossman M, Gupta S, Jeffries J, Huang TJ, Roy Chowdhury J. Transplantation of allogeneic hepatocytes into LDL-receptor deficient rabbits leads to transient improvement in hypercholesterolemia. Clin Biotechnol 1991; 3: 21-26.

34. De Vree JM, Ottenhoff R, Bosma PJ, Smith AJ, Aten J, Oude Elferink RP. Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis. Gastroenterology 2000; 119: 1720-1730.

35. Rozga J, Holzman M, Moscioni AD, Fujioka H, Morsiani E, Demetriou AA. Repeated intraportal hepatocyte transplantation in analbuminemic rats. Cell Transplant 1995; 4: 237-243.

36. Laconi E, Oren R, Mukhopadhyay DK, Hurston E, Laconi S, Pani P, et al. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am J Pathol 1998; 153: 319-329.

37. Guha C, Parashar B, Deb NJ, Garg M, Gorla GR, Singh A, et al. Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection. Hepatology 2002; 36(2): 354-362.

38. Guha C, Sharma A, Gupta S, Alfieri A, Gorla GR, Gagandeep S, et al. Amelioration of radiation induced liver damage in partially hepatectomized rats by hepatocyte transplantation. Cancer Research 1999; 59: 5871-5874.

39. Oren R, Dabeva MD, Karnezis AN, Petkov PM, Rosencrantz R, Sandhu JP, et al. Role of thyroid hormones in stimulating liver repopulation in the rat by transplanted hepatocytes. Hepatology 1999; 30: 903-913.

40. Habibullah CM, Syed IH, Qamar A, Taher-Uz Z. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure. Transplantation 1994; 58(8): 951-952.

41. Strom SC, Fisher RA, Thompson MT, Sanyal AJ, Cole PE, Ham JM, Posner MP. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure. Transplantation 1997; 63(4): 559-569.

42. Bilir BM, Guinette D, Karrer F, Kumpe DA, Krysl J, Stephens J, et al. Hepatocyte transplantation in acute liver failure. Liver Transplantation 2000; 6(1): 32-40.

43. Mito M, Kusano M. Hepatocyte transplantation in man. Cell Transplantation 1993; 2: 65-74.

44. Mito M, Kusano M, Ohnishi T, Saito T, Ebata H. Hepatocellular transplantation. Gastroenterol Jpn 1978; 13: 480-490.

45. Strom SC, Roy Chowdhury J, Fox IJ. Hepatocyte transplantation for the treatment of human disease. Semin Liver Dis 1999; 19: 39-48.

46. Fox IJ, Roy Chowdhury JR, Kaufmann SS, Goertzen TC, Chowdhury NR, Warkentin PI, et al. Treatment of Crigler-Najjar syndrome type 1 with hepatocyte transplantation. N Engl J Med 1998; 338(20): 1422-1426.

47. Horslen SP, McCowan TC, Guertzen TC, Warkentin PI, Strom SC, Fox IJ. Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics (in press).

48. Reyes J, Rubenstein WS, Mieles L, Strom SC, Towbin RB, Trucco M, et al. The use of cultured hepatocyte infusion via the portal vein for the treatment of ornithine transcarbamoylase deficiency by transplantation of enzymatically competent ABO/Rh- matched cells [abstract]. Hepatology 1996; 24: 308A.

49. Muraca M, Gerunda G, Neri D, Vilei MT, Granato A, Feltracco P, et al. Hepatocyte transplantation as a treatment for glycogen storage disease type 1a. Lancet 2002, 359(9303): 317-318.

50. Sokal EM, Smets F, Bourgois A, Van Maldergem L, Buts JP, Reding R, et al. Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up. Transplantation 2003; 76: 735–73.