2006, Number 4
<< Back
Vet Mex 2006; 37 (4)
Clinical-pathological diagnosis of ethylene glycol poisoning: A case report
García-Ortuño LE, Bouda J, Jardón HG, Morales SE
Language: English/Spanish
References: 18
Page: 503-512
PDF size: 457.43 Kb.
ABSTRACT
The objective of this study was to present the most important clinical-pathological fi ndings of ethylene glycol poisoning for early diagnosis and adequate treatment. A clinical case of a female dog which consumed a toxic amount of ethylene glycol and presented tachycardia, tachypnea, seizures and vomiting, is described blood samples were taken for determination of acid-base equilibrium, hemogram and serum chemistry. The laboratory changes were: partially compensated metabolic acidosis, increased anion gap, relative erythrocytosis, leukogram response to stress, renal hyperazotemia and monohydrate calcium oxalate crystals
in urine sediment. Calcium oxalate crystals in renal tubules and brain observed by histopathology confi rmed ethylene glycol poisoning. The adequate use of laboratory tests and the early diagnosis, as well as the early treatment, determine the prognosis of the animal.
REFERENCES
Gaynor AR, Drupa N. Acute ethylene glycol intoxication. Part I. Compend Contin Educ Pract Vet 1999;21:1014-1022.
Grauer FG, Thrall MA. Ethylene glycol (antifreeze) poisoning in the dog and cat. J Am Anim Hos Assoc 1982;18:492-497.
Khan SA, Schell MM, Tramel HL, Hansen SR, Knighy MW. Ethylene glycol exposures managed by the ASPCA National Animal Poison Control Center from july 1995 to december 1997. Vet Human Toxicol 1999;41:403-406.
Hewlett TP, Jacobsen DM, Collins TD, McMartin KE. Ethylene glycol y glycolate kinetics in rats and dogs. Vet Hum Toxicol 1989;31:116-120.
Thrall MA, Grauer GF, Dial S. Envenenamiento por anticongelante. En: Kirk WR, editores. Terapéutica ve-terinaria de pequeños animales. México, DF:Mc Graw-Hill Interamericana, 1997:254-259.
Jones TC, Hunt RD, King NW. Veterinary pathology. 6th ed. Baltimore:Lippincott Williams & Wilkins, 1997.
Di Bartola SP. Terapéutica de líquidos en pequeñas especies. 2nd ed. México DF: Mc Graw-Hill Interameri-cana, 2000.
Testerman WT. Ethilene glycol (antifreeze) poison-ing: a diagnostic challenge. Vet Med Small Anim Clin 1983;75-77.
Coppo NB, Sandoval GL, Scorza SH, Pochón DO, Sán-chez MN, Coppo JA. Fisiopatología de la necrosis tubu-lar experimental en riñones de ratas y perros. Vet Arg 1991;78:533-541.
Nicholson SS. Toxicología. En: Ettinger SJ, Feldman EC, editores. Tratado de medicina interna veterinaria. Bogotá, Colombia: Inter-Médica, 2002:398-399.
Grauer GF, Trhall MA, Henre BA, Grauer MR, Hamar LW. Early clinicophatologic fi ndings in dogs ingesting ethylene glycol. Am J Vet Res 1984;11:2299-2303.
Thrall MA, Dial SM, Winder DR. Identifi cation of cal-cium oxalate monohydrate crystals by X-ray diffraction in urine of ethylene glycol-intoxicated dogs. Vet Pathol 1985;22:625-628.
Gaynor AR, Drupa N. Acute ethylene glycol intoxication. Part II. Compend Contin Educ Pract Vet 1999;21:1124-1133.
Confer AW, Panicera RJ. The urinary system. In: McGavin DM, Carlton WW, Zachary FJ, editors. Thom-sons’s special veterinary pathology. Missouri:Mosby 2001:250-251.
Franklin FF, Cowell RL, Brobst DF, Moore MP. X-ray powder diffraction and microscopic analysis of crystal-luria in dogs with ethylene glycol poisoning. Am J Vet Res 1985;11:2404-2408.
Nelson RW, Turnwald HG, Willard DM. Trastornos endocrinos, metabólicos y lipídicos. En: Willard MD, Tvedten H, Turnwald GH, editores. Diagnóstico clíni-copatológico práctico en los animales pequeños. Buenos Aires:Inter-Médica 2002:148.
Bush BM. Interpretación de los análisis de laboratorio para clínicos de pequeños animales. Barcelona:Har-court,1999.
Latimer KS, Mahaffey EA, Prasse KW. Veterinary labo-ratory medicine. Clinical pathology. 4th ed. Iowa: Iowa State Press, 2003.