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2007, Number 2

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Vet Mex 2007; 38 (2)

Peripheral nerve sheath tumor in the cervical area of the vertebral canal in a dog

Carvallo CF, Bermúdez ME, Constantino CF, Santoscoy MC, Montesinos RLI, Gómez RC

Language: English/Spanish
References: 24
Page: 241-247
PDF size: 303.77 Kb.


ABSTRACT

The case of a domestic, mixed breed, six-year-old, male dog is presented. The dog had a progressive history of nonambulatory tetraparesis which caused tetraplegia, muscle atrophy, absence of superfi cial sensibility, hyporefl exia of the thoracic limbs and neck pain to palpation. Magnetic resonance imaging (MRI) of the neck showed loss of density of the spinal cord at C6-C7 level. The patient was euthanized and the pathological examination confi rmed the presence of neoplastic tissue compressing the spinal cord. Histological features along with intense nuclear and cytoplasmic immune-positiveness to S-100 protein, were consistent of a tumor of the peripheral nerve sheath (schwannoma). Because of its localization, this neoplasm must be differentiated form canine meningioma, which is negative to S-100 immunolabeling. Other neoplasms of fusiform cells that should be ruled out are fi broma, hemangioma, and hemangiopericytoma.


REFERENCES

  1. Koestner A, Bilzer T, Fatzer R, Schulman FY, Summers BA, Van Winkle TJ. Histological classifi cation of tumours of the nervous system of domestic animals. In: The World Health Organization, editor. International histological classifi cation of tumours of domestic animals, 2nd series, Vol 5. Washington DC: Armed Forces Institute of Pathology, 1999:1-71.

  2. Storts RW, Montgomery DL. The Nervous System. In: McGavin D, Carlton W, Zachary J, editors. Thomson´s Special Veterinary Pathology. 3rd ed. St Louis: Mosby Ed, 2001:381-459.

  3. Hajjar MV, Schmidek HH. Operative neurosurgical techniques: Indications, methods and results. Vol. 2. Philadelphia: WB Saunders Ed, 2000: 151-158.

  4. Epstein BS. Afecciones de la columna vertebral y de la médula espinal: estudios radiológicos y clínicos. 3a ed. La Habana: Editorial Científi co Técnica, 1981.

  5. Cordy D. Tumors of the nervous system and eye. In: Moulton JE, editor. Tumors in Domestic Animals. 3rd ed. California: University of California Press, 1990:640-665.

  6. Koestner A, Higgins RJ. Tumors of the nervous system. In: Meuten JD, editor. Tumors of domestic animals. 4th ed. Iowa: Iowa State Press, 2002: 697-738.

  7. Fingeroth JM, Prata RG, Patnaik AK. Spinal meningiomas in dogs: 13 cases (1972-1987). J Am Vet Med Assoc 1987;191:720-726.

  8. Luttgen PJ, Braund KG, Brawner JR. A retrospective study of twenty-nine spinal tumors in the dog and cat. J Small Anim Pract 1980;21:213-226.

  9. Wright JA, Bell DA, Clayton-Jones DG. The clinical and radiological features associated with spinal tumors in thirty dogs. J Small Anim Pract 1979;20:461-472.

  10. Solleveld HA, Bigner DD, Arverill Jr DR, Bigner SH, Boorman GA, Burger PC et al. Brain tumors in man and animals: Reports of a Workshop. Environ Health Perspect 1986; 68:155-173.

  11. Nittner K. Spinal meningiomas, neuromas and neurofi - bromas, and hour-glass tumors. In: Vinken PH, Bruyn GW, editors. Handbook of clinical neurology. New York: North Holland/America Elsevier Ed, 1976:177-322.

  12. Levy WJ, Latchaw J, Hahn JF, Sawhny B, Bay J, Dohn DF. Spinal neurofi bromas: A report of 66 cases and a comparison with meningiomas. Neurosurgery 1986;18:331-334.

  13. Cantore G, Ciappetta P, Delfi ni R. Intramedullary spinal neurinomas. J Neurosurgery 1982;57:143-147.

  14. Juárez M, Aburto E. Revisión de 558 casos de neoplasias cutáneas en perros durante el periodo 2000-2004. Memorias del XIII Congreso Nacional de Patología Veterinaria; 2004 mayo 26-28; Nuevo Vallarta (Nayarit), México. México (DF): Sociedad Mexicana de Patólogos Veterinarios AC, 2004.

  15. Stoica G, Tasca SI, Kim HT. Point mutation of neu oncogene in animal peripheral nerve sheath tumors. Vet Pathol 2001;38:679-688.

  16. Zachary JF, O´Brien DP, Ingles BW, Everitt JI, Parker AJ. Multicentric nerve sheath fi brosarcomas of multiple cranial nerve roots in two dogs. J Am Vet Med Assoc 1986;188:723-726.

  17. Chijiwa K, Uchida K, Tateyama S. Inmunohistochemical evaluation of canine peripheral nerve sheath tumors and other soft tissue sarcomas. Vet Pathol 2004;41:307-318.

  18. Zbieranowski I, Bedard YC. Fine needle aspiration of schwannomas. Value of electron microscopy and inmunohistochemistry in the preoperative diagnosis. Acta Cytol 1989;33:381-384.

  19. Mooney EE, Layfi eld LJ, Dodd LG. Fine-needle aspiration of neural lesions. Diagn Cytopathol 1999;20:1-5.

  20. Domanski HA, Åkerman M, Engellau J, Gustafson P, Mertens F, Rydholm A. Fine needle aspiration of neurilemoma (Schwannoma). A clinicopathologic study of 116 patients. Diagn Cytopathol 2006;34:403-412.

  21. Takeuchi A, Ushigome S. Diverse differentiation in malignant peripheral nerve sheath tumors associated with neurofribromatosis-1. An inmunohistochemical and ultrastructural study. Histopathology 2001;39:298-309.

  22. Chijiwa K, Uchida K, Tateyama S. Inmunohistochemical evaluation of canine peripheral nerve sheath tumors and other soft tissue sarcomas. Vet Pathol 2004;41:307-318.

  23. Canfi eld P. The ultra structure of bovine peripheral nerve sheath tumors. Vet Pathol 1978;15:292-300.

  24. Summers BA, Valentine B, Van Winkle T, Cooper B. Divergent differentiation in canine peripheral nerve sheath tumors. Vet Pathol 1992;29:447.




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