2007, Number S1
<< Back Next >>
Rev Mex Anest 2007; 30 (S1)
Brain protection - The clinical reality
Patel P
Language: English
References: 55
Page: 101-107
PDF size: 72.37 Kb.
Text Extraction
One of the most feared complications of anesthesia and surgery is the occurrence of cerebral ischemia and neuronal injury. Although the incidence of stroke during surgery is quite low, during certain procedures the risk of stroke can be high. For example, the incidence of neurologic complications during cardiac surgery has been reported to be approximately 2-6%
(1). The majority of these complications occur during the intraoperative period
(2). The risk of perioperative stroke in patients undergoing carotid endarterectomy ranges from a high of about 15% to the more recently reported risk of 2.1%
(3). Neurosurgical procedures, particularly aneurysm and AVM surgery, entail a significant risk of ischemia. Given the large number of patients who undergo these procedures, the “at risk” population is substantial. This has fostered a considerable amount of interest in not only evaluating measures designed to prevent cerebral ischemia but also in identifying anesthetic agents that might decrease the brain’s vulnerability to ischemia.
REFERENCES
Tuman KJ, McCarthy RJ, Najafi H, Ivankovich AD. Differential effects of advanced age on neurologic and cardiac risks of coronary artery operations. J Thorac Cardiovasc Surg 1992;104:1510-7.
Reed Gd, Singer DE, Picard EH, DeSanctis RW. Stroke following coronary-artery bypass surgery. A case-control estimate of the risk from carotid bruits. N Engl J Med 1988;319:1246-50.
Collaborators NASCET. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators [see comments]. N Engl J Med 1991;325:445-53.
Siesjo BK. Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metab 1981;1:155-85.
Benveniste H, Drejer J, Schousboe A, Diemer NH. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984;43:1369-74.
Choi DW. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends in Neurosci 1988;11:465-9.
Todd MM, Chadwick HS, Shapiro HM, et al. The neurologic effects of thiopental therapy following experimental cardiac arrest in cats. Anesthesiology 1982;57:76.
Warner DS, Zhou J, Ramani R, Todd MM. Reversible focal ischemia in the rat: Effects of halothane, isoflurane, and methohexital anesthesia. J Cereb Blood Flow Metab 1991;11:794-802.
Drummond JC. Do barbiturates really protect the brain? Anesthesiology 1993;78:611-3.
Warner DS, Takaoka S, Wu B et al. Electroencephalographic burst suppression is not required to elicit maximal neuroprotection from pentobarbital in a rat model of focal cerebral ischemia. Anesthesiology 1996;84:1475-84.
Baughman VL, Hoffman WE, Thomas C, et al. Comparison of methohexital and isoflurane on neurologic outcome and histopathology following incomplete ischemia in rats. Anesthesiology 1990;72:85-94.
Soonthon-Brant V, Patel PM, Drummond JC, et al. Fentanyl does not increase brain injury after focal cerebral ischemia in rats. Anesth Analg 1999;88:49-55.
Nellgard B, Mackensen GB, Pineda J, et al. Anesthetic effects on cerebral metabolic rate predict histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology 2000;93:431-6.
Warner DS, McFarlane C, Todd MM, et al. Sevoflurane and halothane reduce focal ischemic brain damage in the rat. Anesthesiology 1993;79:985-92.
Werner C, Mollenberg O, Kochs E, Schulte JaE. Sevoflurane improves neurological outcome after incomplete cerebral ischaemia in rats. Br J Anaesth 1995;75:756-60.
Engelhard K, Werner C, Reeker W, et al. Desflurane and isoflurane improve neurological outcome after incomplete cerebral ischaemia in rats. Br J Anaesth 1999;83.
Du C, Hu R, Csernansky C, et al. Very delayed infarction after mild focal cerebral ischemia: A role for apoptosis? J Cereb Blood Flow Metab 1996;16:195-201.
Kawaguchi M, Kimbro JR, Drummond JC et al. Isoflurane delays but does not prevent cerebral infarction in rats subjected to focal ischemia. Anesthesiology 2000;92:1335-42.
Engelhard K, Werner C, Eberspacher E, et al. Sevoflurane and propofol influence the expression of apoptosis-regulating proteins after cerebral ischaemia and reperfusion in rats. Eur J Anaesthesiol 2004;21:530-7.
Gelb AW, Bayona NA, Wilson JX, Cechetto DF. Propofol anesthesia compared to awake reduces infarct size in rats. Anesthesiology 2002;96:1183-90.
Pittman JE, Sheng H, Pearlstein RD et al. Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarction size after temporary focal ischemia in the rat. Anesthesiology 1997;87:1139-44.
Bayona NA, Gelb AW, Jiang Z, et al. Propofol neuroprotection in cerebral ischemia and its effects on low molecular weight antioxidants and skilled motor tasks. Anesthesiology 2004.
Engelhard K, Werner C, Eberspacher E, et al. Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation. Anesthesiology 2004;101:912-7.
Sano T, Patel PM, Drummond JC, Cole DJ. A comparison of the cerebral protective effects of etomidate, thiopental and isoflurane in a model of forebrain ischemia in the rat. Anesth Analg 1993;76:990-7.
Drummond JC, McKay LD, Cole DJ, Patel PM. The role of nitric oxide synthase inhibition in the adverse effects of etomidate in the setting of focal cerebral ischemia in rats. Anesth Analg 2005;100:841-6, table of contents.
Busto R, Dietrich WD, Globus MYT, et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 1987;7:729-38.
Sano T, Drummond JC, Patel PM et al. A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a rat model of incomplete forebrain ischemia. Anesthesiology 1992;76:221-8.
Chen Q, Chopp M, Bodzin G, Chen H. Temperature modulation of cerebral depolarization during focal cerebral ischemia in rats: correlation with ischemic injury. J Cereb Blow Flow Metab 1993;13:389-94.
Morikawa E, Ginsberg MD, Dietrich WD, et al. The significance of brain temperature in focal cerebral ischemia: Histopathological consequences of middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 1992;12:380-9.
Ridenour TR, Warner DS, Todd MM, McAllister AC. Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Stroke 1992;23:733-8.
Todd MM, Hindman BJ, Clarke WR, Torner JC. Mild intraoperative hypothermia during surgery for intracranial aneurysm. N Engl J Med 2005;352:135-45.
Shiozaki T, Sugimoto H, Taneda M et al. Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 1993;79:363-8.
Marion DW, Obrist WD, Carlier PM et al. The use of moderate therapeutic hypothermia for patients with severe head injuries: A preliminary report. J Neurosurg 1993;79:354-62.
Clifton GL, Allen S, Barrodale P et al. A phase II study of moderate hypothermia in severe brain injury. J Neurotrauma 1993;10:263-71.
Clifton GL, Miller ET, Choi SC, et al. Lack of effect of induction of hypothermia after acute brain injury. NEJM 2001;344:556-63.
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549-56.
Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557-63.
Dietrich WD, Busto R, Valdes I, Loor Y. Effects of normothermic versus mild hyperthermic forebrain ischemia in rats. Stroke 1990;21:1318-25.
Chan KH, Dearden NM, Miller JD, et al. Multimodality monitoring as a guide to treatment of intracranial hypertension after severe brain injury. Neurosurgery 1993;32:547-52.
Schwarz S, Georgiadis D, Aschoff A, Schwab S. Effects of induced hypertension on intracranial pressure and flow velocities of the middle cerebral arteries in patients with large hemispheric stroke. Stroke 2002;33:998-1004.
Rordorf G, Koroshetz WJ, Ezzeddine MA, et al. A pilot study of drug-induced hypertension for treatment of acute stroke. Neurology 2001;56:1210-3.
Marzan AS, Hungerbuhler HJ, Studer A, et al. Feasibility and safety of norepinephrine-induced arterial hypertension in acute ischemic stroke. Neurology 2004;62:1193-5.
Cole DJ, Matsumura JS, Drummond JC, et al. The effect of hypertension on reperfusion cerebral blood flow following temporary middle cerebral artery occlusion. J Neurosurg Anesthesiol 1990;2:211-6.
Siesjo BK, Katsura K, Mellergard, P et al. Acidosis-related brain damage. Prog Brain Res 1993;96:23-48.
Myers RE, Yamaguchi S. Nervous system effects of cardiac arrest in monkeys. Preservation of vision. Arch Neurol 1977;34:65-74.
Warner DS, Gionet TX, Todd MM, McAllister AM. Insulin-induced normoglycemia improves ischemic outcome in hyperglycemic rats. Stroke 1992;23:1775-80; discussion 81.
Pulsinelli WA, Levy DE, Sigsbee B, et al. Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus. Am J Med 1983;74:540-4.
Weir CJ, Murray GD, Dyker AG, Lees KR. Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long-term follow up study. Bmj 1997;314:1303-6.
Bruno A, Levine SR, Frankel MR, et al. Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial. Neurology 2002;59:669-74.
Auer RN. Hypoglycemic brain damage. Metab Brain Dis 2004;19:169-75.
van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359-67.
Goldberg PA, Sakharova OV, Barrett PW, et al. Improving glycemic control in the cardiothoracic intensive care unit: clinical experience in two hospital settings. J Cardiothorac Vasc Anesth 2004;18:690-7.
Wass CT, Lanier WL. Glucose modulation of ischemic brain injury: review and clinical recommendations. Mayo Clin Proc 1996;71:801-12.
Ruta TS, Drummond JC, Cole DJ. The effect of acute hypocapnia on local cerebral blood flow during middle cerebral artery occlusion in isoflurane anesthetized rats. Anesthesiology 1992;78:134-40.
The Brain Trauma Foundation. The American Association of Neurological Surgeons. The Joint Section on Neurotrauma and Critical Care. Hyperventilation. J Neurotrauma 2000;17:513-20.