medigraphic.com
ISSN 1405-1699 (Print)
Órgano Oficial del Colegio Mexicano de Alergia, Asma e Inmunología Pediátrica y de la Asociación Latinoamericana de Pediatría

2006, Number 3

<< Back Next >>

Alerg Asma Inmunol Pediatr 2006; 15 (3)

Effectiveness of the inhaled sodium chromoglycate in asthmatic patients of the Pediatrician Hospital “Angel Arturo Aballi”. Preliminary study

Bilbao DMF, Gutiérrez BM, Notario RM, Fernández MSA, Valdivieso VJ, Rodríguez GY, Valdés RCYC

Language: Spanish
References: 13
Page: 85-89
PDF size: 237.37 Kb.


ABSTRACT

Bronchial Asthma is a chronic inflammatory disease of the airways. In Cuba is the main cause of hospital admittance in children. Sodium chromoglycate has been shown to be one of the choice treatments because of its efficacy and the absence of collateral effects. It was decided to evaluate the effectiveness of the inhaled sodium chromoglycate in the treatment of mild and moderate persistent asthma in pediatric patients. A preliminary study of effectiveness was carried out, prospective and longitudinally during 3 months with 10 male and female asthma patients, ages 6 to 9, at Ángel Arturo Aballí Pediatric Hospital. The 90% of patients corresponded to the age group of 6 to 9 years old, with a predominance of the female sex (70%). The absence of hospital admittance during the study was relevant (p = 0.01). On the other hand, after week 6, an increase in the percentage of PEF was observed in 80% of the patients (p = 0.009), maintaining a stability of the ventilatory function among normal values. The results of this study are related to what is established in the literature about the effectiveness of inhaled sodium chromoglycate in the preventive treatment of mild persistent asthma.


REFERENCES

  1. Murphy S, Kelly HW. Asthma, inflammation, and airway hyperresponsiveness in children. Current Opinion in Pediatrics 1993; 5: 255-265.

  2. Beveridge R, Grunfeld A, Hodder R, Verbeek P. Guidelines for the emergency management of asthma in adults. Can Med Assoc J 1996; 155: 25-37.

  3. Rachelefsky GS, Warner JO. International consensus on the management of pediatric asthma: a summary statement. Pediatr Pulmonol 1993; 15: 125-127.

  4. Anonymous. British Guidelines on Asthma Management. Thorax 1997; 52 Suppl: S1-S21.

  5. Iniciativa Global para el Asma 2002. Disponible en URL: http://www. infodoctor.org/respirar

  6. Boulet LP, Becker A, Berube D, Beveridge R, Ernst P. Canadian asthma consensus report, 1999. Can Med Assoc J 1999; 161 (11 Suppl): S1-S72.

  7. Lipworth BJ. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Arch Intern Med 1999; 159: 941-955.

  8. Wolthers OD, Honour JW. Hypothalamic-pituitary-adrenal function in children with asthma and rhinitis treated with topical glucocorticoids. Clin & Experimental Allergy 1998; 28: 545-550.

  9. Efthimiou J, Barnes PJ. Effect of inhaled corticosteroids on bones and growth. [Review] Eur Respir J 1998; 11: 1167-1177.

  10. Knudson RJ. Changes in the normal maximal expiratory flow-volume curve with growth and aging. Am Rev Respir Dis 1983; 127(6): 725-34.

  11. Abdo A, Cue M. Situación actual y futuro del asma bronquial en Cuba 2002. Disponible en URL: http://www.respirar.org/forolatino/cuba.htm.

  12. Stone H. Asma bronquial 2000. Disponible en URL: http://www.copeson.org.mx/informacion/asma.htm.

  13. Abascal ME, Grau R, La Rosa A. Valores normales de flujo espiratorio forzado en la población de Ranchuelo. Rev Cub Med 2001; 40(40): 243-52.




2020     |     www.medigraphic.com