Mármol SA, Herrera VR, Gutiérrez GF, Alfonzo GJP, Leyva TC, Bacallao GJ

Language: Spanish
References: 0
Page: 1-11
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ABSTRACT

Introduction: Renal transplantation is one of the methods of renal function substitution and the main factor influencing survival is the immunological compatibility of the major system.
Objectives: To define transplant survival and the relationship with the degree of compatibility.
Methods: A retrospective study was carried out on the hospital-based survival time of 512 transplants from 1993 to 2010, including follow-up and the cut at the end of 2019. The Kaplan-Meier estimator was used to calculate the survivals, the statistical package Statistical Package Social Science (Spss) version 22.0 was used.
Results: Three hundred ninety seven (397) patients received cadaveric kidneys at the cut, 11.3% of the grafts were functioning, 115 received living grafts, 45.2%, p=0.000. The median survival for the cadaveric kidneys was 3.1 years (SD 2.4-3.8) and among them those who shared three or more antigens achieved twice the survival, p=0.033. For the living donor, the median was 16.0 years (SD 9.1-22.9) and within this group, 104 patients, sharing a haplotype, achieved 44.2% function, siblings, who were identical, achieved 66 .0%. By kinship, those who received kidneys from siblings have better survival than for those who received it from parents, p=0.001.
Conclusions: Immunological compatibility of the major system between donor and recipient was defined to favor differences in the function of the grafts.