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2022, Number 3

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Rev Cubana Hematol Inmunol Hemoter 2022; 38 (3)

Clinical importance of the diagnosis of methemoglobinemia

Tamayo RY, Agramonte LOM, Miguel MM

Language: Spanish
References: 40
Page: 1-16
PDF size: 700.26 Kb.


ABSTRACT

Introduction: Methemoglobin is a form of hemoglobin in which the heme group, usually in the ferrous form, is oxidized to the ferric form, which affects oxygen transport. The increase above the reference values ​​is called methemoglobinemia.
Objective: To update concepts such as prevention, clinical manifestations, laboratory diagnosis and treatment of choice for this disease, with the information available from the last decade.
Methods: A review of the literature in English and Spanish was carried out, through the PubMed website, the academic Google search engine and Scielo database, of articles published in the last 10 years. Search terms used included methemoglobinemia, cytochrome b5 reductase deficiency, cyanosis, and co-oximetry.
Analysis and synthesis of information: Methemoglobinemia can be classified into congenital and acquired, the latter being the most common. It is important to diagnose this disease, which, although it is a rare condition, can cause serious complications, and even death, which are avoidable with early diagnosis and timely treatment that reduce the complications associated with this condition.
Conclusions: The diagnosis and treatment, prophylactic and therapeutic, of methemoglobinemia, in its acute or maintenance stage, require adequate updating of the health professional.


REFERENCES

  1. Paul A, Chacko ST. Congenital methaemoglobinaemia diagnosed in an adolescent boy. BMJ Case Rep. 2019;12(3):e228470. DOI: https:// 10.1136/bcr-2018-228470

  2. Tang M, Zhou Y, Zhang R, Wang LV. Noninvasive photoacoustic microscopy of methemoglobin in vivo. J Biomed Opt. 2015;20(3):036007. DOI: https:// 10.1117/1.JBO.20.3.036007

  3. Naymagon L, Berwick S, Kessler A, Lancman G, Gidwani U, Troy K. The emergence of methemoglobinemia amidst the covid-19 pandemic. Am J Hematol. 2020;95(8):E196-E197. DOI: https:// 10.1002/ajh.25868

  4. Khan K, White-Gittens I, Saeed S, Ahmed L. Benzocaine-Induced Methemoglobinemia in a Postoperative Bariatric Patient following Esophagogastroduodenoscopy. Case Rep Crit Care. 2019;1571423. DOI: https:// 10.1155/2019/1571423

  5. Grillo M, Hong J, Kosuri S, Verma R. Cetirizine as a Causative Agent for Drug Induced Methemoglobinemia: A Case Report and Review. J Pediatr Pharmacol Ther. 2019; 24(6):538-41. DOI: https:// 10.5863/1551-6776-24.6.538

  6. Mahmood N, Khan MU, Haq IUL, Jelani FA, Tariq A. A case of dapsone induced methemoglobinemia. J Pharm Policy Pract. 2019;12:22. DOIhttps:// : 10.1186/s40545-019-0185-y

  7. Carreira R, Palaré MJ, Prior AR, Garcia P, Abrantes M. An unusual cause of neonatal cianosis. BMJ Case Rep. 2015;bcr2014208371. DOI: https:// 10.1136/bcr-2014-208371

  8. Deeny J, Murdock ET, Rogan JJ. Familial Idiopathic Methaemoglobinaemia: Treatment with Ascorbic Acid. Br Med J. 1943;1(4301):721-3. DOI: https:// 10.1136/bmj.1.4301.721

  9. Moloney C, Long A, Pastores GM, Plant BJ, Murphy DM. A bolt from the blue; A case report of an unusual asthma exacerbation. Respir Med Case Rep. 2019;29:100983. DOI: https:// 10.1016/j.rmcr.2019.100983

  10. Al-Khafaji JF, Sharma M, Nayeemuddin K, Al-Qaysi IA, Al-Mashhadani AA, Taha ME, et al10. . Acuteleukemia in congenital methehemoglobinemia - an enigma to explore. J Community Hosp Intern Med Perspect. 2018; 9(1):55-8. DOI: https:// 10.1080/20009666.2018.1555431

  11. Orlandi M, Amadi MA, Goldaracena PX, Péreza FE. Cianosis en un paciente de 14 años. Presentación de un caso de metahemoglobinemia. Arch Argent Pediatr. 2018;116(3):e429-32. Spanish. DOI: https:// 10.5546/aap.2018.e429

  12. Shin C, Hong M, Kim M, Lee JH. Exon sequencing of the alpha-2-globin gene for the differential diagnosis of central cyanosis in newborns: a case report. BMC Pediatr. 2019;19(1):221. DOI: https:// 10.1186/s12887-019-1601-9

  13. Kim DS, Baek HJ, Kim BR, Yoon BA, Lee JH, Kook H. The First Korean Family with Hemoglobin-M Milwaukee-2 Leading to Hereditary Methemoglobinemia. Yonsei Med J. 2020; 61(12):1064-1067. DOI: https://10.3349/ymj.2020.61.12.1064

  14. Ghotra S, Jangaard K, Pambrun C, Fernandez CV. Congenital methemoglobinaemia due to Hb F-M-Fort Ripley in a preterm newborn. BMJ Case Rep. 2016;bcr2016214381. DOI: https:// 10.1136/bcr-2016-214381

  15. Soliman DS, Yassin M. Congenital methemoglobinemia misdiagnosed as polycythemia vera: Case report and review of literature. Hematol Rep. 2018;10(1):7221. DOI: https:// 10.4081/hr.2018.7221

  16. McNally JS, Jaffey JA, Kim SE, Alexander MD, Shumway KL, Cohn LA, et al16. . Methemoglobin Modulation as an Intravascular Contrast Agent for Magnetic Resonance Imaging: Proof of Concept. Front VetSci. 2019;6:416. DOI: https:// 10.3389/fvets.2019.00416

  17. Guedri R, Missaoui N, Essaddam L, Ben Becher S. A rare cause of cyanosis: Congenital methemoglobinemia. Clin Case Rep. 2021;9(7):e04422. DOI: https:// 10.1002/ccr3.4422

  18. Siendones E, Ballesteros M, Navas P. Cellular and Molecular Mechanisms of Recessive Hereditary Methaemoglobinaemia Type II. J Clin Med. 2018;7(10):341. DOI: https:// 10.3390/jcm7100341

  19. Gutenberg LL, Chen JW, Trapp L. Methemoglobin levels in generally anesthetized pediatric dental patients receiving prilocaine versus lidocaine. Anesth Prog. 2013;60(3):99-108. DOI: https:// 10.2344/0003-3006-60.3.99

  20. Lepe-Zúñiga JL, Aguilar-Gómez LE, Godínez-Téllez NC. Metahemoglobinemia adquirida en el recién nacido asociada con benzocaína y paracetamol. Bol Med Hosp Infant Mex. 2015;72(4):271-5. DOI: https:// 10.1016/j.bmhimx.2015.07.005

  21. Paccor A, Matsuda M, Capurso C, Rizzo E, Larroca MC. Metahemoglobinemia inducida por dapsona: presentación de un caso pediátrico. Arch Argent Pediatr. 2018;116(4):e612-5. DOI: https:// 10.5546/aap.2018.e612

  22. Pascale A, Echevarren V, Pan M, Forteza C, García A. Metahemoglobinemia relacionada con ingesta de puré de acelgas. Arch Pediatr Uruguay. 2017;88(6):335-40. DOI: https://org/10.31134/ap.88.66.

  23. Hakeem KR, Sabir M, Ozturk M, Akhtar MS, Ibrahim FH. Nitrate and Nitrogen Oxides: Sources, Health Effects and Their Remediation. Rev Environ Contam Toxicol. 2017;242:183-217. DOI: https:// 10.1007/398_2016_11

  24. Ward MH, Jones RR, Brender JD, de Kok TM, Weyer PJ, Nolan BT, et al24. . Drinking Water Nitrate and Human Health: An Updated Review. Int J Environ Res Public Health. 2018;15(7):1557. DOI: https:// 10.3390/ijerph15071557

  25. Laiz Averhoff OR. Caracterización de la calidad de las aguas del embalse Maurín, para su uso sostenible. Municipio Bauta, provincia Artemisa, Cuba. Aqua-LAC. 2016;8(2):55-70. DOI: https://doi.org/10.29104/phi-aqualac/2016-v8-2-0625.

  26. Kim YJ, Sohn CH, Ryoo SM, Ahn S, Seo DW, Lee YS, et al26. . Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. Clin Toxicol (Phila). 2016;54(7):581-4. DOI: https:// 10.1080/15563650.2016.1178759

  27. Tan YA, Ng KC, Cheo SW, Khoo TT, Low QJ. A case of dapsone-induced methaemoglobinaemia. Clin Med (Lond). 2020;20(5):519-21. DOI: https:// 10.7861/clinmed.2020-0364

  28. Fernández-Merjildo D, Zegarra Piérola J, Heredia Orbegoso O, Meza García M. Exanguinotransfusión como tratamiento de metahemoglobinemia secundaria a dapsona. Reporte de caso. Rev Médica Herediana. 2016;27:243-6. DOI:https://doi.org/10.20453/rmh.v27i4.299428.

  29. Pérez-Tuñón JG, Martiñón-Ríos R, Figueroa-Rivera M. Metahemoglobinemia por fenazopiridina: reporte de un caso con enfoque diagnóstico. Acta Pediátr Méx. 2018;39(6):355-60. DOI: https://doi.org/10.18233/APM39No6pp355-360173329.

  30. Viršilas E, Timukienė L, Liubšys A. Congenital methemoglobinemia: Rare presentation of cyanosis in newborns. Clin Pract. 2019;9(4):1188. DOI: https:// 10.4081/cp.2019.1189

  31. Cefalu JN, Joshi TV, Spalitta MJ, Kadi CJ, Diaz JH, Eskander JP, et al31. . Methemoglobinemia in the Operating Room and Intensive Care Unit: Early Recognition, Pathophysiology, and Management. Adv Ther. 2020; 37(5):1714-23. DOI: https:// 10.1007/s12325-020-01282-5

  32. Iolascon A, Bianchi P, Andolfo I, Russo R, Barcellini W, Fermo E, et al32. . Recommendations for diagnosis and treatment of methemoglobinemia. Am J Hematol. 2021;96(12):1666-78. DOI: https:// 10.1002/ajh.26340

  33. Shihana F, Dawson AH, Dissanayake DM. Method of stabilizing blood for the determination of methemoglobin. J Clin Lab Anal. 2011;25(5):366-8. DOI: https:// 10.1002/jcla.20487

  34. Haykır N, NarterF,Güllü M, Aslan MB. Methemoglobinemia after prilocaine application during neonatal circumcision and treatment with ascorbic acid. Southern Clin Istanbul Eurasia. 2018;29(3):209-12. DOI: https:// 10.14744/scie.2018.40412

  35. Gupta K, Jha M, Jadon R, Sood R. Case of methaemoglobinaemia caused by tree oils and kerosene. BMJ Case Rep. 2017;2017:bcr2017220802. DOI: https:// 10.1136/bcr-2017-220802

  36. Alonso-Ojembarrena A, Lubián-López SP . Hemoglobin M. Disease as a Cause of Cyanosis in a Newborn. J Pediatr Hematol Oncol. 2016;38(3):173-5. DOI: https:// 10.1097/MPH.0000000000000489

  37. Canning J, Levine M. Case files of the medical toxicology fellowship at Banner Good Samaritan Medical Center in Phoenix, AZ: methemoglobinemia following dapsone exposure. J Med Toxicol. 2011;7(2):139-46. DOI: https:// 10.1007/s13181-011-0151-9

  38. Alzaki AA, Alalawi NH. Diabetic Ketoacidosis Revealing Severe Glucose-6-Phosphate Dehydrogenase Deficiency (G6PD-D) Deficiency with Methemoglobinemia: A Case Report. Am J Case Rep. 2019; 20:726-9. DOI: https:// 10.12659/AJCR.915007

  39. Sepúlveda RA, Barnafi E, Rojas V, Jara A. Metahemoglobinemia, una entidad de diagnóstico complejo. Reporte de un caso. Rev Med Chile. 2020;148(12):1838-43. DOI:https://doi.org/10.4067/S0034-9887202000120183839.

  40. Poulin LD, Riopel J, Castonguay V, Mac-Way F. Acute oxalate nephropathy induced by oral high-dose vitamin C alternative treatment. Clin Kidney J. 2014;7(2):218. DOI: https:// 10.1093/ckj/sfu013




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