medigraphic.com

2025, Number 2

<< Back Next >>

Rev Mex Anest 2025; 48 (2)

The role of anesthetics in liver damage

Madariaga-Traconis AP, Gamez-Castro MD, Barbero-Becerra VJ

Language: Spanish
References: 38
Page: 98-102
PDF size: 368.35 Kb.


ABSTRACT

Drug-induced liver injury is a condition where the liver suffers due to drug administration, which is detected by the elevation of aminotransferases, alkaline phosphatase and serum bilirubin levels. In an acute episode, halothane, acetaminophen and diclofenac have been pointed out mainly as the drugs responsible for this condition. The knowledge of the characteristics of different types of anesthetics, such as metabolism pathways, mechanism of action and elimination, could be useful in order to considered them in various scenarios and their potential clinical applications.


REFERENCES

  1. Soler E. Anestesiología [Internet]. 2002, 777-803 p. (Farmacia Hospitalaria; vol. Capítulo 2). Disponible en: https://www.sefh.es/bibliotecavirtual/fhtomo2/CAP02.pdf

  2. García AB. Conceptos básicos de anestesia [Internet]. 2020. Disponible en: http://www.oc.lm.ehu.eus/Departamento/OfertaDocente/Teledocencia/Leioa/Odonto/Cap%2039%20Anestesia.pdf

  3. Víctor CE. Toxicidad anestésicos inhalatorios. Disponible en: https://www.fmed.uba.ar/sites/default/files/2018-03/tox_anestesicos_inhalatorios.pdf

  4. Pérez-Hernández JL, Juárez-García FI, García-Espinosa IA, Medina-Ávalos EJ, Higuera-De La Tijera MDF. Lesión hepática inducida por fármacos anestésicos. Rev Mex Anestesiol. 2022;45:188-191.

  5. Krawitt EL. Autoimmune hepatitis. N Engl J Med. 2006;354:54-66. Available in: https://doi.org/10.1056/NEJMra050408

  6. Krishna B. Inhaled anesthetics for sedation in ICU: widening horizons! Indian J Crit Care Med. 2022;26:889-891.

  7. Stachnik J. Inhaled anesthetic agents. Am J Health Syst Pharm. 2006;63:623-634.

  8. Massart J, Begriche K, Moreau C, Fromenty B. Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. J Clin Transl Res. 2017;3:212-232. Available in: https://doi.org/10.18053/jctres.03.2017S1.006

  9. Eghtesadi-Araghi P, Sohrabpour A, Vahedi H, Saberi-Firoozi M. Halothane hepatitis in Iran: a review of 59 cases. World J Gastroenterol. 2008;14:5322-5326.

  10. De La Torre Carazo S, De La Torre Carazo F, Jiménez Pérez C, Ramos Meca MA, De La Torre Gutiérrez S. Anestesia para colonoscopia: anestesia inhalatoria con sevoflurano frente a anestesia intravenosa con propofol. Sanid Mil. 2012;68:27-32.

  11. Wei Y, Zhang D, Liu J, Ou M, Liang P, Zuo Y, et al. Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study. BMC Anesthesiol. 2021;21:80.

  12. Fernández-Meré LA, Muñoz González F, Sopena Zubiria LA, Álvarez Blanco M. Sevoflurano y disfunción hepática. Revista Española de Anestesiología y Reanimación. 2008;55:184-185.

  13. Benoit L, Dieu A, Foguenne M, Bonaccorsi-Riani E. Experimental and clinical aspects of sevoflurane preconditioning and postconditioning to alleviate hepatic ischemia-reperfusion injury: a scoping review. Int J Mol Sci. 2023;24:2340.

  14. Butterworth JF. Morgan & Mikhail's. Clinical anesthesiology. 5th ed. New York, USA: McGraw-Hill Education; 2013.

  15. Penna SA, Gutiérrez RR. Neurociencia y anestesia. Revista Médica Clínica Las Condes. 2017;28:650-660.

  16. Chokshi T, Channabasappa S, Vergheese DC, Bajwa SJS, Gupta B, Mehdiratta L. Re-emergence of TIVA in COVID times. Indian J Anaesth. 2020;64:S125-S131. Available in: https://doi.org/10.4103/ija.IJA_554_20

  17. Zhang Z, Tian L, Jiang K. Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway. Int Immunopharmacol. 2019;77:105974.

  18. Meierhenrich R, Gauss A, Mühling B, Bracht H, Radermacher P, Georgieff M, et al. The effect of propofol and desflurane anaesthesia on human hepatic blood flow: a pilot study. Anaesthesia. 2010;65:1085-1093.

  19. Regueiro-Purriños M, Ajenjo JM, Pérez De Prado A, García-Gómez M, Altónaga JR, Gonzalo-Orden JM, et al. Anestesia en el modelo animal de investigación cardiovascular. Revista Española de Cardiología Suplementos. 2013;13:47-56.

  20. Davis PJ, Cook DR. Clinical pharmacokinetics of the newer intravenous anaesthetic agents. Clin Pharmacokinet. 1986;11:18-35.

  21. Yeung JK, Zed PJ. A review of etomidate for rapid sequence intubation in the emergency department. CJEM. 2002;4:194-198.

  22. Dávila CVE, Morejón HJM, Acosta FE. Pain and painkillers. Some timely considerations. MediSur. 2020;18:694-705.

  23. Sahinovic MM, Struys MMRF, Absalom AR. Clinical pharmacokinetics and pharmacodynamics of propofol. Clin Pharmacokinet. 2018;57:1539-1558.

  24. Gumussoy M, Gokcan H, Bodakci E, Kiremitci S, Savas B, Idilman R. NSAID-associated drug-induced liver injury prior to and following liver transplantation. Hepatol Forum. 2022;3:108-109. Available in: https://hepatologyforum.org/article/99

  25. Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75:859-877. Available in: https://doi.org/10.1007/s40265-015-0392-z

  26. Dragoi D, Benesic A, Pichler G, Kulak NA, Bartsch HS, Gerbes AL. Proteomics analysis of monocyte-derived hepatocyte-like cells identifies integrin beta 3 as a specific biomarker for drug-induced liver injury by diclofenac. Front Pharmacol. 2018;9:699.

  27. Hogestatt ED, Jonsson BA, Ermund A, Andersson DA, Bjork H, Alexander JP, et al. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 2005;280:31405-31412.

  28. Athersuch TJ, Antoine DJ, Boobis AR, Coen M, Daly AK, Possamai L, Nicholson JK, Wilson ID. Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective. Toxicol Res (Camb). 2018;7:347-357.

  29. Krenkel O, Mossanen JC, Tacke F. Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg Nutr. 2014;3:331-343.

  30. Kuna L, Bozic I, Kizivat T, Bojanic K, Mrso M, Kralj E, et al. Models of drug induced liver injury (DILI) - current issues and future perspectives. Curr Drug Metab. 2018;19:830-838.

  31. Ghanem CI, Pérez MJ, Manautou JE, Mottino AD. Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity. Pharmacological Research, 2016;109:119-131. Available in: https://doi.org/10.1016/j.phrs.2016.02.020

  32. Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: a comprehensive update. J Clin Transl Hepatol. 2016;4:131-142. Available in: https://doi.org/10.14218/JCTH.2015.00052

  33. Chalasani N, Younossi Z, Lavine JE, Charlton M, Cusi K, Rinella M, et al. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67:328-357.

  34. Ishak KG. Hepatic lesions caused by anabolic and contraceptive steroids. Semin Liver Dis. 1981;1:116-128.

  35. Werner M, Prytz H, Ohlsson B, Almer S, Bjornsson E, Bergquist A, et al. Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: a nationwide study. Scand J Gastroenterol. 2008;43(10):1232-1240. Available in: https://doi.org/10.1080/00365520802130183

  36. Kanzler S, Weidemann C, Gerken G, Lohr HF, Galle PR, Meyer zum Büschenfelde KH, et al. Clinical significance of autoantibodies to soluble liver antigen in autoimmune hepatitis. J Hepatol. 1999;31:635-640. Available in: https://doi.org/10.1016/S0168-8278(99)80342-0

  37. Bischoff S, Yesmembetov K, Antoni C, Sollors J, Evert M, Ebert M, et al. Autoimmune hepatitis: a review of established and evolving treatments. J Gastrointestin Liver Dis. 2020;29(3):429-443. Available in: https://doi.org/10.15403/jgld-2667

  38. Tan CK, Ho D, Wang LM, Kumar R. Drug-induced autoimmune hepatitis: a minireview. World J Gastroenterol. 2022;28:2654-2666. Available in: https://doi.org/10.3748/wjg.v28.i24.2654




2020     |     www.medigraphic.com