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ISSN 1990-7990 (Electronic)
Revista Universitaria

2022, Number 2

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Universidad Médica Pinareña 2022; 18 (2)

Clinical experience in an infant with Langerhans cell histiocytosis

Pita-Barrios Y, Peralta-Santiesteban S, Blanco-Gómez CA

Language: Spanish
References: 13
Page: 1-6
PDF size: 513.99 Kb.


ABSTRACT

Introduction: Langerhans cell histiocytosis (LCH) or Histiocytosis X is a benign proliferative disease affecting dendritic cells. It presents a wide clinical spectrum, from isolated eosinophilic bone granuloma to multisystem involvement with multiple organ failure with or without resistance to chemotherapy.
Case report: a 4-month-old male infant, with no family history of hematooncologic disease; his condition began two months earlier with lesions on the scalp, trunk, axillae and inguinal folds, and irritability. The family physician prescribed non-steroidal anti-inflammatory drugs with no improvement and the patient was referred to the dermatology department. Clinical examination revealed adynamia, hyporexia and weight loss, increased irritability on palpation of the hips, increased volume of the left leg and cervical lymphadenopathy. Additional tests were performed and a diagnosis of Langerhans cell histiocytosis was made. Treatment was started with six mercaptopurine and vinblastine, blood product transfusions and treatment with Filgastrim, the patient showed clinical improvement.
Conclusions: Langerhans cell histiocytosis is a complex and rare disease which pathophysiology and prognosis have not yet been widely described. It is difficult to diagnose due to its heterogeneous presentation and its treatment must be individualized. This disease represents a challenge, and it is important to raise awareness among medical personnel of the need to deepen their knowledge with reference to the disease in order to establish a timely diagnosis and management.


REFERENCES

  1. Rosas Saldarriaga S. Histiocitosis de células de Langerhans e imágenes diagnósticas. CES Med [Internet]. 2016 [citado 11/11/2020]; 30(2):231-7. Disponible en: https://revistas.ces.edu.co:443/index.php/medicina/article/view/3252

  2. Morán VE, Durán MC, Orozco CL, Palacios LC, Sáez-de-Ocáriz M, García RMT. Histiocitosis de células de Langerhans: nuevos conceptos moleculares y clínicos. Dermatología Cosmética, Médica y Quirúrgica [Internet]. 2018 [citado 11/11/2020]; 16(1):36-44. Disponible en: https://www.medigraphic.com/pdfs/cosmetica/dcm-2018/dcm181g.pdf

  3. Aljure V, Suárez D, Téllez L, Torres L, Vargas C. Histiocitosis de células de Langerhans: Presentación de caso y revisión de la literatura. Rev. Colomb. Radiol [Internet]. 2018 [citado 11/11/2020]; 29(2):4936-9. Disponible en: http://contenido.acronline.org/Publicaciones/RCR/RCR29-2/RCR-29-2-09_Histocitosis%20WEB.pdf

  4. García-Rodríguez E, Bernabeu-Wittel J, Calderón-Lópeza G, Pavón-Delgado A. Histiocitosis de células de Langerhans con debut neonatal atípico y precoz. Arch Argent Pediatr [Internet]. 2016 [citado 11/11/2020]; 114(2):104-107. Disponible en: http://www.scielo.org.ar/pdf/aap/v114n2/v114n2a21.pdf

  5. Murga A, Burgos R, Basurco A, Cari E, Cabrejos J, Laos E, Polo C, Salas J. Histiocitosis de células de Langerhans en columna vertebral dorsal en paciente pediátrico. Peru J Neurosurg [Internet]. 2020 [citado 11/11/2020]; 2(3):95-99. Disponible en: https://perujournalneurosurgery.org/sites/default/files/HISTIOCITOSIS%20DE%20CELULAS%20DE%20LANGERHANS%20EN%20COLUMNA%20VERTEBRAL%2C%20EN%20PACIENTE%20PEDIATRICO%20Spanish.pdf

  6. Araújo Cuauro JC. Histiocitosis de células de Langerhans sistémica invasiva con afectación pulmonar y manifestaciones no específicas en la infancia. Presentación de un caso y actualización del tema. VITAE Academia Biómedica Digital [Internet]. 2017 [citado 11/11/2020]; 2017(9):49-58. Disponible en: http://vitae.ucv.ve/pdfs/VITAE_5605.pdf

  7. Giraldo-Grueso M, Villegas María C, Rodríguez David L, Rodríguez Edison. Histiocitosis de células de Langerhans con compromiso vertebral. Bol. Med. Hosp. Infant. Mex. [Internet]. 2018 [citado 11/11/2020]; 75(5):309-312. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462018000500309&lng=es

  8. Pedroso Delgado JC, Pila Pérez R, Rosales Torres P, Rivera Lecha I. Histiocitosis de células de Langerhans ósea a forma poliostótica. A propósito de un caso. Medisur [Internet]. 2019 [citado 11/11/2020]; 17(4):578-585. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1727-897X2019000400578&lng=es

  9. Madero López L, Soques Vallejo E. Histiocitosis o enfermedades histiocitarias. Rev Pediatr Integral [Internet]. 2016 [citado 11/11/2020]; 20(6):412–417. Disponible en: https://www.pediatriaintegral.es/wp-content/uploads/2016/09/Pediatria-Integral-XX-06_WEB.pdf#page=69

  10. Cepeda B, Hernández M, Altamirano C. Histiocitosis X. RevSEOT [Internet]. 2018 [citado 11/11/2020]; 7(2):93-8. Disponible en: http://revistacientificaseot.com/index.php/revseot/article/view/57

  11. Arias Fuente M. Trabajo de fin de grado: estudio clínico evolutivo de la histiocitosis de células de Langerhans en la infancia [Tesis de fin de estudios]. Valladolid: Universidad de Valladolid; 2017. 18 p. Recuperado de: https://uvadoc.uva.es/handle/10324/24264

  12. Barrios K, Patiño O, Muñoz N, Moneriz C. Histiocitosis congénita de células de Langerhans. Biomédica [Internet]. 2020 [citado 11/11/2020]; 40(3):464-71. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/5150

  13. De la Torre-González DM, Ramírez-Castañeda JG, Aguilar-Loeza DJ, Jardinez-Muñoz MA. Histiocitosis de células de Langerhans en columna lumbar en paciente pediátrico. Rev Hosp Jua Mex [Internet]. 2016 [citado 11/11/2020]; 83(4):165-168. Disponible en: https://www.medigraphic.com/cgi-bin/new/resumenI.cgi?IDARTICULO=70918#




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