2022, Number 2
Main reasons that cancer is too difficult to treat
Language: English
References: 6
Page: 1-3
PDF size: 114.16 Kb.
Text Extraction
Mr. Editor:Cancer is one of the largest global causes of death worldwide. In 2018 alone, around one in six deaths will be caused by cancer; 9,6 million people worldwide have been afflicted by cancer. While cancer has been detected since the 18th century, for this deadly disease we still do not have a standardized cure. The current approach to battling cancer care is on-going, pending major progress. The purpose of this study is to figure out why it is so difficult to treat cancer.
Treating cancer isn’t easy because it ultimately involves fighting your own body. Under the influence of the environment, genetics and unhealthy lifestyle, some cells break out of control. These cells start growing and quickly multiply while carrying a genetic mutation that allows them to divide uncontrollably. Eventually, they become tumors and start invading different tissues and organs. Cancer cells turn into hidden enemies within us. Newly formed cancer cells create an entire microenvironment around themselves. Cancer cells stimulate the formation of neovessels, which proliferate rapidly in most types of cancer. These vessels are then used to feed cancer cells and help them grow. This process of blood vessel formation is called angiogenesis. The new blood vessels support cancer cells by providing them with oxygen and nutrients.
REFERENCES
Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, et al. Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res[Internet]. 2015[cited 01/09/2020]; 75:544–553.Disponible en: https://doi.org/10.1158/0008-5472.CAN-14-2211
Wang Z, Liu F, Fan N, Zhou C, Li D, Macvicar T, Dong Q, Bruns CJ, Zhao Y. Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies. Front Oncol[Internet]. 2020[cited 01/09/2020]; 10:589508.Disponible en: https://doi:10.3389/fonc.2020.589508.