2022, Number 2
Epidemiologic and anatomopathologic study of uveal melanoma
Language: Spanish
References: 21
Page: 1-9
PDF size: 318.68 Kb.
ABSTRACT
Objective: To determine the epidemiologic and anatomopathologic behavior of uveal melanoma.Methods: Descriptive, longitudinal and retrospective study in patients enucleated for diagnosis of uveal melanoma in the Ophthalmologic Center of Villa Clara from January 2010 to May 2021.
Results: The average age of presentation of uveal melanoma was 61.3 years. Women were slightly more affected than men-56.3%. 81.3 percent of uveal melanomas originated in the choroid. Epithelioid and spindle cell tumors were the most representative; both with 37.5%. The average thickness and basal diameter of the tumors studied were 11.2mm and 15.8mm respectively; medium-sized tumors prevailed with 56.3%. Tumor infiltration was found in 37.5% of the eyes, scleral infiltration was the most frequent.
Conclusions: Uveal melanoma occurs more frequently in people with advanced age and in the choroid. Histological study confirms the diagnosis in all cases. Approximately 2/3 of the tumors with some degree of infiltration are large and half are epithelioid cells.
REFERENCES
Aragonés CB, García GFR, Alemañy GJ, Chen Y, Domínguez de la Vega Y. Frecuencia de cáncer oftalmológico y su reporte en el Hospital Clínico Quirúrgico “Hermanos Ameijeiras”. Rev Acta Médica. 2017 [acceso: 11/05/2021];18(1). Disponible en: Disponible en: https://www.medigraphic.com/pdfs/actamedica/acm-2017/acm171g.pdf 5.
Sumba A, Romano D, Amarillo D, Schiavone A, Delgado L, Krygier G. Melanoma ocular: reporte de 24 casos de la Unidad de Melanoma del Hospital de Clínicas Dr. Manuel Quintela, Montevideo, Uruguay. Oftalmol Clin Exp. 2020 [acceso: 11/05/2021];13(1):11-22. Disponible en: Disponible en: https://revistaoce.com/index.php/revista/article/view/5/15 7.
Mahendraraj K, Lau CSM, Lee I, Chamberlain RS. Trends in incidence, survival, and management of uveal melanoma: a population-based study of 7,516 patients from the Surveillance, Epidemiology, and End Results database (1973-2012). Clin Ophthalmol. 2016 [acceso: 11/05/2021];10:2113-19. Disponible en: Disponible en: https://www.dovepress.com/trends-in-incidence-survival-and-management-of-uveal-melanoma-a-popula-peer-reviewed-fulltext-article-OPTH 10.
Prado Serrano A, Camas Benítez JT, Bosque Vega M, Reyna Vielma S. Características ecográficas de melanomas uveales en población mexicana (serie de casos). Rev Mex Oftalmol. 2014 [acceso: 11/05/2021];88(4):200-04. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/pii/S0187451914000699 11.
Vicente N, Saornil MA, García-Álvarez C, Almaraz A, Alonso Martínez P, Frutos-Barajad JM, et al12. . Melanoma uveal: características clínicas, tratamiento y supervivencia en una serie de 500 pacientes. Arch de la Soc Esp de Oftalmo. 2013 [acceso: 11/05/2021];88(11):433-38. Disponible en: Disponible en: https://www.elsevier.es/es-revista-archivos-sociedad-espanola-oftalmologia-296-articulo-melanoma-uveal-caracteristicas-clinicas-tratamiento-S036566911300227X 12.
Fernández González O, Abreu Perdomo F, Hernández Perugorría A, Santos Silva D, Ortiz Ramos D, Rojas Rondón I, et al14. . Caracterización clínico patológica del melanoma uveal. Revista Cubana de Oftalmología. 2018 [acceso: 11/05/2021];31(4). Disponible en: Disponible en: http://www.revoftalmologia.sld.cu/index.php/oftalmologia/article/view/627/html_361 14.
Walter SD, Chao DL, Feuer W, Schiffman J, Char DH, Harbour JW. Prognostic Implications of Tumor Diameter in Association with Gene Expression Profile for Uveal Melanoma. JAMA Ophthalmol. 2016 [acceso: 11/05/2021];134(7):734-40. Disponible en: Disponible en: https://pubmed.ncbi.nlm.nih.gov/27123792/ 15.
Afshar AR, Damato BE, Stewart JM, Zablotska LB, Roy R, Olshen AB, et al16. . Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis. Trans. Vis. Sci. Tech. 2019 [acceso: 11/05/2021];8(2):18. Disponible en: Disponible en: https://tvst.arvojournals.org/article.aspx?articleid=2731609 16.
Damato B, Eleuteri A, Hussain R, Kalirai H, Thornton S, Taktak A, et al18. . Parsimonious Models for Predicting Mortality from Choroidal Melanoma. Invest. Ophthalmol. Vis. Sci. 2020 [acceso: 11/05/2021];61(4):35. Disponible en: Disponible en: https://iovs.arvojournals.org/article.aspx?articleid=2765357 18.
Binkley E, Triozzi PL, Rybicki L, Achberger S, Aldrich W, Singh A. A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes. Br J Ophthalmol. 2020 [acceso: 11/05/2021];104:524-28. Disponible en: Disponible en: https://bjo.bmj.com/content/bjophthalmol/104/4/524.full.pdf 19.
Thornton S, Coupland SE, Heimann H, Hussain R, Groenewald C, Kacperek A, et al. Effects of plaque brachytherapy and proton beam radiotherapy on prognostic testing: a comparison of uveal melanoma genotyped by microsatellite analysis. Br J Ophthalmol. 2020 [acceso: 11/05/2021];104:1462-6. Disponible en: https://dx.doi.org/10.1136%2Fbjophthalmol-2019-31536320.
Eleuteri A, Taktak AFG, Coupland SE, Heimann H, Kalirai H, Damato B. Prognostication of metastatic death in uveal melanoma patients: A Markov multi-state model. Comput Biol Med. 2018 [acceso: 11/05/2021];102:151-6. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S0010482518302865?via%3Dihub 21.