2024, Number 4
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Rev Fac Med UNAM 2024; 67 (4)
Natural Antioxidants and their Effect Against Oxidative Stress Caused by Particulate Matter Pollution
Cervantes-Valencia ME, López-Valdez N, Rojas-Lemus M, González-Villalva A, Morales-Ricardes G, Bizarro-Nevares P, Ustarroz-Cano M, Salgado-Hernández JÁ, Mendoza-Martínez S, Lamas-Orozco LM, Fortoula TI
Language: Spanish
References: 73
Page: 7-20
PDF size: 2282.63 Kb.
ABSTRACT
Environmental pollution can promote oxidative stress by
exposing the body to various elements and substances that
generate free radicals, such as lead and vanadium. These
free radicals can negatively impact the respiratory, cardiovascular,
immune, and neurological systems of vulnerable
populations, including children, the elderly, and those with
chronic diseases. To prevent or reduce oxidative stress, it is
recommended to consume a balanced diet rich in natural
antioxidants. These antioxidants can be found in various
foods, especially in fruits and vegetables with intense colors,
seeds, and spices. In recent decades, the effectiveness
of consuming natural antioxidants such as resveratrol (found
in wine), coffee, curcumin, garlic, vitamin C, vitamin E, and
green tea has been demonstrated. These antioxidants have
beneficial effects on the body, including the protection of
cell membranes, regulation of gene expression associated
with inflammation, prevention or reduction of endothelial
damage, and the decrease or diminished severity of neurodegeneration,
liver, and pulmonary disorders. Additionally,
they stimulate the immune response.
REFERENCES
World Health Organization. Air pollution is one of thebiggest environmental threats to human health, alongsideclimate change [Internet]. 2023 [citado:2024 Feb 14]. Disponibleen: https://www.who.int/news-room/fact-sheets/detail/household-air-pollution-and-health?gad_source=1&gclid=Cj0KCQjw-_mvBhDwARIsAA-Q0Q4CMelelPrDWOxDqmzwNpF7U4-AIEu6tYhasF5irgZ4mUcFiDClkawaAiAlEALw_wcB
Dominski FH, Lorenzetti Branco JH, Buonanno G, StabileL, Gameiro da Silva M, Andrade A. Effects of air pollutionon health: A mapping review of systematic reviews and meta-analyses. Environ Res [Internet]. 2021;201:111487. Disponibleen: https://doi.org/10.1016/j.envres.2021.111487
Thangavel P, Park D, Lee Y-C. Toxicity of airborne particles—established evidence, knowledge gaps and emergingareas of importance. Int J Environ Res Public Heal [Internet].2022;19(12):7511. Disponible en: https://www.mdpi.com/1660-4601/19/12/7511
Alkadi H. A Review on Free Radicals and Antioxidants.Infect Disord - Drug Targets. 2022;20(1):16-26.
Korovesis D, Rubio-Tomás, T Tavernarakis N. Oxidativestress in age-related neurodegenerative diseases: An overviewof recent tools and findings. Antioxidants. 2023;12(1):131.
Jomova K, Raptova R, Alomar SY, Alwasel SH, NepovimovaE, Kuca K, et al. Reactive oxygen species, toxicity, oxidativestress, and antioxidants: chronic diseases and aging[Internet]. Vol. 97, Archives of Toxicology. Springer BerlinHeidelberg; 2023. 2499-2574 p. Disponible en: https://doi.org/10.1007/s00204-023-03562-9
Peng ML, Fu Y, Wu CW, Zhang Y, Ren H, Zhou SS.Signaling Pathways Related to Oxidative Stress in DiabeticCardiomyopathy. Front Endocrinol (Lausanne).2022;13(junio):1-20.
Rotariu D, Babes EE, Tit DM, Moisi M, Bustea C,Stoicescu M, et al. Oxidative stress – Complex pathologicalissues concerning the hallmark of cardiovascularand metabolic disorders. Biomed Pharmacother [Internet].2022;152(abril):113238. Disponible en: https://doi.org/10.1016/j.biopha.2022.113238
Akel Bilgic H, Kilic B, Kockaya BD, Sarac BE, Kilic SulogluA, Kalayci O, et al. Oxidative stress stimulation leadsto cell-specific oxidant and antioxidant responses in airwayresident and inflammatory cells. Life Sci [Internet].2023;315(December):121358. Disponible en: https://doi.org/10.1016/j.lfs.2022.121358
Ortiz Escarza JM, Medina López ME. Estrés oxidativo ¿unasesino silencioso? Educ Química. 2020;31(1):2.
Świątkiewicz I, Wróblewski M, Nuszkiewicz J, Sutkowy P,Wróblewska J, Woźniak A. The Role of Oxidative StressEnhanced by Adiposity in Cardiometabolic Diseases. IntJ Mol Sci. 2023;24(7).
Barbier E, Carpentier J, Simonin O, Gosset P, Platel A,Happillon M, et al. Oxidative stress and inflammation inducedby air pollution-derived PM2.5 persist in the lungs ofmice after cessation of their sub-chronic exposure. EnvironInt. 2023;181(agosto).
Monged MHE, Imam NG, Aquilanti G, Pollastri S, RashadAM, Osán J. Heavy metals concentrations and speciationof Pb and Ni in airborne particulate matter over two residentialsites in Greater Cairo - reflection from synchrotronradiation. J Synchrotron Radiat. 2022;29:765-74.
Rojas-Lemus M, López-Valdez N, Bizarro-Nevarez P,González-Villalva A, Ustarroz-Cano M, Zepeda-RodríguezA, et al. Toxic effects of inhaled vanadium attachedto particulate matter: a literature review. Int J Environ ResPublic Health. 2021;18(8457):1-16.
Valko M, Jomova K, Rhodes CJ, Kuča K, Musílek K.Redox- and non-redox-metal-induced formation of freeradicals and their role in human disease. Vol. 90, Archivesof Toxicology. 2016. 1-37 p.
Ghio AJ, Stonehuerner J, Soukup JM, Dailey LA, Kesic MJ,Cohen MD. Iron diminishes the in vitro biological effectof vanadium. J Inorg Biochem [Internet]. 2015;147:126-33. Disponible en: http://dx.doi.org/10.1016/j.jinorgbio.2015.03.008
Li CJ. Oxidative stress and mitochondrial dysfunction inhuman diseases: Pathophysiology, predictive biomarkers,therapeutic. Biomolecules. 2020;10(11):1-3.
Su L, Zhang J, Gomez H, Kellum JA, Peng Z. MitochondriaROS and mitophagy in acute kidney injury. Autophagy[Internet]. 2023;19(2):401-14. Disponible en: https://doi.org/10.1080/15548627.2022.2084862
Wang JP, Huang XY, Zhang KY, Ding XM, Zeng QF, BaiSP, et al. Involvement of P38 and ERK1/2 in mitochondrialpathways independent cell apoptosis in oviduct magnumepithelial cells of layers challenged with vanadium. EnvironToxicol. 2018;33(12):1312-20.
Mateos-Nava RA, Rodríguez-Mercado JJ, Álvarez-BarreraL, García-Rodríguez M del C, Altamirano-Lozano MA.Vanadium oxides modify the expression levels of the p21,p53, and Cdc25C proteins in human lymphocytes treatedin vitro. Environ Toxicol. 2021;36(8):1536-43.
Adekeye AO, Fafure AA, Ogunsemowo AE, Enye LA,Saka OS, Ogedengbe OO. Naringin ameliorates motordysfunction and exerts neuroprotective role against vanadium-induced neurotoxicity. AIMS Neurosci. 2022;9(4):536-50.
Ahmad F, Haque S, Ravinayagam V, Ahmad A, Kamli MR,Barreto GE, et al. Developmental lead (Pb)-induced deficitsin redox and bioenergetic status of cerebellar synapsesare ameliorated by ascorbate supplementation. Toxicology[Internet]. 2020;440(abril):152492. Disponible en: https://doi.org/10.1016/j.tox.2020.152492
Elsheikh NAH, Omer NA, Yi-Ru W, Mei-Qian K, IlyasA, Abdurahim Y, et al. Protective effect of betaine againstlead-induced testicular toxicity in male mice. Andrologia.2020;52(7):1-8.
Adekeye AO, Fafure AA, Omodele MM, Adedayo LD,Ekundina VO, Adekomi DA, et al. Flavonoid glycosidefraction of Ginkgo biloba extract modulates antioxidantsimbalance in vanadium-induced brain damage. AIMSNeurosci. 2023;10(2):178-89.
De la Fuente M. Effects of antioxidants on immune systemageing. Eur J Clin Nutr. 2002;56:S5-8.
Kurutas EB. The importance of antioxidants which play therole in cellular response against oxidative/nitrosative stress:Current state. Nutr J [Internet]. 2016;15(1):1-22. Disponibleen: http://dx.doi.org/10.1186/s12937-016-0186-5
Hajhashemi V, Vaseghi G, Pourfarzam M, Abdollahi A.Are antioxidants helpful for disease prevention? Res PharmSci. 2010;5(1):5-12.
Tian B, Liu J. Resveratrol: a review of plant sources, synthesis,stability, modification and food application. J SciFood Agric. 2020;100(4):1392-404.
Galiniak S, Aebisher D, Bartusik-Aebisher D. Healthbenefits of resveratrol administration. Acta Biochim Pol.2019;66(1):13-21.
Shin JW, Lee HS, Na JI, Huh CH, Park KC, Choi HR.Resveratrol inhibits particulate matter-induced inflammatoryresponses in human keratinocytes. Int J Mol Sci.2020;21(10):1-11.
Lian Y, Li Y, Liu A, Ghosh S, Shi Y, Huang H. Dietary antioxidantsand vascular calcification: From pharmacologicalmechanisms to challenges. Biomed Pharmacother [Internet].2023;168(octubre):115693. Disponible en: https://doi.org/10.1016/j.biopha.2023.115693
Morvaridzadeh M, Sadeghi E, Agah S, Nachvak SM, FazelianS, Moradi F, et al. Effect of melatonin supplementationon oxidative stress parameters: A systematic review andmeta-analysis. Pharmacol Res [Internet]. 2020;161:105210.Disponible en: https://doi.org/10.1016/j.phrs.2020.105210
Ahmad SB, Ali A, Bilal M, Rashid SM, Wani AB, Bhat RR,et al. Melatonin and Health: Insights of Melatonin Action,Biological Functions, and Associated Disorders. Cell MolNeurobiol [Internet]. 2023;43(6):2437-58. Disponible en:https://doi.org/10.1007/s10571-023-01324-w
Hardeland R. Neurobiology, pathophysiology, and treatmentof melatonin deficiency and dysfunction. Sci WorldJ. 2012;2012:1-18.
Mehrzadi S, Sheibani M, Koosha F, Alinaghian N, PourhanifehMH, Tabaeian SAP, et al. Protective and therapeuticpotential of melatonin against intestinal diseases:updated review of current data based on molecular mechanisms.Expert Rev Gastroenterol Hepatol [Internet].2023;17(10):1011-29. Disponible en: https://doi.org/10.1080/17474124.2023.2267439
Pérez-Torres I, Aisa-Álvarez A, Casarez-Alvarado S, BorrayoG, Márquez-Velasco R, Guarner-Lans V, et al. Impact ofTreatment with Antioxidants as an Adjuvant to StandardTherapy in Patients with Septic Shock: Analysis of the Correlationbetween Cytokine Storm and Oxidative Stress andTherapeutic Effects. Int J Mol Sci. 2023;24(23):16610.
Schichlein KD, Smith GJ, Jaspers I. Protective effects ofinhaled antioxidants against air pollution-induced pathologicalresponses. Respir Res [Internet]. 2023;24(1):1-11.Disponible en: https://doi.org/10.1186/s12931-023-02490-7
Martini D, Del Bo’ C, Tassotti M, Riso P, Rio D Del, BrighentiF, et al. Coffee consumption and oxidative stress: A reviewof human intervention studies. Molecules. 2016;21(8):979-99.
Grosso G, Godos J, Galvano F, Giovannucci EL. Coffee,Caffeine, and Health Outcomes: An Umbrella Review.Annu Rev Nutr. 2017;37:131-56.
Gupta SC, Patchva S, Koh W, Aggarwal BB. Discoveryof curcumin, a component of golden spice, and its miraculousbiological activities. Clin Exp Pharmacol Physiol.2012;39(3):283-99.
Kunnumakkara AB, Bordoloi D, Padmavathi G, MonishaJ, Roy NK, Prasad S, et al. Curcumin, the golden nutraceutical:multitargeting for multiple chronic diseases. Br JPharmacol. 2017;174(11):1325-48.
Hu Y, Cheng L, Du S, Wang K, Liu S. Antioxidant curcumininduces oxidative stress to kill tumor cells (Review).Oncol Lett. 2024;27(2):1-12.
Yudhistira B, Punthi F, Lin J-A, Syahrullah AS, ChangC-K, Hsieh C-W. S-Allyl cysteine in garlic (Allium sativum):Formation, biofunction, and resistance to foodprocessing for value-added product development. ComprRev FOOD Sci FOOD Saf [Internet]. 2022;21(3):2662-87.Disponible en: https://doi.org/10.1111/1541-4337.12937
Espinosa-Zurutuza M, González-Villalva A, Albarrán-Alonso JC, Colín-Barenque L, Bizarro-Nevares P,Rojas-Lemus M, et al. Oxidative Stress as a MechanismInvolved in Kidney Damage After Subchronic Exposureto Vanadium Inhalation and Oral Sweetened Beverages ina Mouse Model. Int J Toxicol. 2018;37(1):45-52.
Ozma MA, Abbasi A, Ahangarzadeh Rezaee M, HosseiniH, Hosseinzadeh N, Sabahi S, et al. A Critical Review onthe Nutritional and Medicinal Profiles of Garlic’s (Alliumsativum L.) Bioactive Compounds. Food Rev Int [Internet].2023;39(9):6324-61. Disponible en: https://doi.org/10.1080/87559129.2022.2100417
Zakarova A, Seo JY, Kim HY, Kim JH, Shin JH, Cho KM,et al. Garlic sprouting is associated with increased antioxidantactivity and concomitant changes in the metaboliteprofile. J Agric Food Chem. 2014;62(8):1875-80.
Carr AC, Lykkesfeldt J. Vitamin c: From bench to bedside.Nutrients. 2021;13(4):13-5.
Arrigoni O, De Tullio MC. Ascorbic acid: Much more thanjust an antioxidant. Biochim Biophys Acta - Gen Subj.2002;1569(1-3):1-9.
Rojas-Lemus M, Bizarro-Nevares P, E. González-Villalva A,López-Valdéz N, Rivera-Fernández N, I. Fortoul T. GenotoxicEffects of Oral Ascorbate in Healthy Mice: Evaluationof DNA Single-strand Breaks and Micronucleus. J FoodNutr Res. 2022;10(8):578-83.
Zwolak I. Protective Effects of Dietary Antioxidants againstVanadium-Induced Toxicity: A Review. Oxid Med CellLongev. 2020;2020.
Shahidi, Pinaffi-Langley A, Fuentes J, Speisky H, De CamargoAC. Vitamin E as an essential micronutrient forhuman health: Common, novel, and unexplored dietarysources. Free Radic Biol Med. 2021;176:312-21.
Shahidi F, De Camargo AC. Tocopherols and tocotrienolsin common and emerging dietary sources: Occurrence,applications, and health benefits. Int J Mol Sci.2016;17(10):1-29.
Halliwell B. Understanding mechanisms of antioxidantaction in health and disease. Nat Rev Mol Cell Biol.2024;25(1):13-33.
Mumtaz S, Ali S, Khan R, Shakir HA, Tahir HM, MumtazS, et al. Therapeutic role of garlic and vitamins C and Eagainst toxicity induced by lead on various organs. EnvironSci Pollut Res. 2020;27(9):8953-64.
Kumar M, Deshmukh P, Kumar M, Bhatt A, Sinha AH,Chawla P. Vitamin E Supplementation and CardiovascularHealth: A Comprehensive Review. Cureus. 2023;15(11).
Barthelemy J, Sanchez K, Miller MR, Khreis H. New opportunitiesto mitigate the burden of disease caused by trafficrelated air pollution: Antioxidant-rich diets and supplements.Int J Environ Res Public Health. 2020;17(2):1-27.
Miller III ER, Pastor-Barriuso R, Dalal D, Riemersma RA,Appel LJ, GUallar E. Meta-analysis: High-dosage vitaminE supplementation may increase all-cause mortality.Evidence-Based Eye Care. 2005;6(2):88-9.
Ambigaipalan P, Oh WY, Shahidi F. Epigallocatechin(EGC) esters as potential sources of antioxidants. FoodChem [Internet]. 2020;309:125609. Disponible en: https://doi.org/10.1016/j.foodchem.2019.125609
Musial C, Kuban-Jankowska A, Gorska-Ponikowska M.Beneficial properties of green tea Catechins. Int J Mol Sci.2020;21(1744):27-56.
Olson KR, Briggs A, Devireddy M, Iovino NA, Skora NC,Whelan J, et al. Green tea polyphenolic antioxidants oxidizehydrogen sulfide to thiosulfate and polysulfides: A possiblenew mechanism underpinning their biological action. RedoxBiol [Internet]. 2020;37:101731. Disponible en: https://doi.org/10.1016/j.redox.2020.101731
Yong H, Hu H, Wang Z, Yun D, Kan J, Liu J. Structure,stability and antioxidant activity of dialdehyde starchgrafted with epicatechin, epicatechin gallate, epigallocatechinand epigallocatechin gallate. J Sci Food Agric.2022;102(14):673-86.
Jhang KA, Park JS, Kim HS, Chong YH. ResveratrolAmeliorates Tau Hyperphosphorylation at Ser396 Site andOxidative Damage in Rat Hippocampal Slices Exposed toVanadate: Implication of ERK1/2 and GSK-3β SignalingCascades. J Agric Food Chem. 2017;65(44):9626-34.
Akinyemi AJ, Onyebueke N, Faboya OA, OnikanniSA, Fadaka A, Olayide I. Curcumin inhibits adenosinedeaminase and arginase activities in cadmium-inducedrenal toxicity in rat kidney. J Food Drug Anal [Internet].2017;25(2):438-46. Disponible en: http://dx.doi.org/10.1016/j.jfda.2016.06.004
Alhusaini A, Fadda L, Hasan IH, Zakaria E, Alenazi AM,Mahmoud AM. Curcumin ameliorates lead-induced hepatotoxicityby suppressing oxidative stress and inflammation,and modulating akt/gsk-3β signaling pathway. Biomolecules.2019;9(11).
Ghasemi S, Hosseini M, Feizpour A, Alipour F, SadeghiA, Vafaee F, et al. Beneficial effects of garlic on learningand memory deficits and brain tissue damages inducedby lead exposure during juvenile rat growth is comparableto the effect of ascorbic acid. Drug Chem Toxicol.2017;40(2):206-14.
Kumar MV, Henley AK, Nelson CJ, Indumati O, Rao P,Rajanna S, et al. Protective effect of Allium sativum (garlic)aqueous extract against lead-induced oxidative stress in therat brain, liver, and kidney. Environ Sci Pollut Res [Internet].2017;24(2):1544-52. Disponible en: http://dx.doi.org/10.1007/s11356-016-7923-3
Sharma S, Sharma K, Sharma V. Garlic essential oil confersshielding against nephrotoxicity elicited by lead nitrate inSwiss albino mice. Appl Biol Chem J. 2023;4:102-12.
García-Rodríguez M del C, Hernández-Cortéz LM, Altamirano-Lozano M. In Vivo Effects of Vanadium Pentoxideand Antioxidants (Ascorbic Acid and Alpha-Tocopherol) onApoptotic, Cytotoxic, and Genotoxic Damage in PeripheralBlood of Mice. Oxid Med Cell Longev. 2016;2016:1-11.
Nam SM, Chang BJ, Kim JH, Nahm SS, Lee JH. Ascorbicacid ameliorates lead-induced apoptosis in the cerebellarcortex of developing rats. Brain Res [Internet].2018;1686:10-8. Disponible en: https://doi.org/10.1016/j.brainres.2018.02.014
Sheikh M El, Ashry A, Rahman A, El-nassr SS. PossibleProtective Effect of Vitamin E on The Joined Cardio-RenalEffects of Lead Toxicity and Noise Stress in Rats INTRODUCTION: 2014;35(1):1-10.
Khodamoradi N, Komaki A, Salehi I, Shahidi S, SarihiA. Effect of vitamin E on lead exposure-induced learningand memory impairment in rats. Physiol Behav [Internet].2015;144:90-4. Disponible en: http://dx.doi.org/10.1016/j.physbeh.2015.03.015
García-Rodríguez MDC, Serrano-Reyes G, Hernández-Cortés LM, Altamirano-Lozano M. Antigenotoxic effectsof (-)-epigallocatechin-3-gallate (EGCG) and its relationshipwith the endogenous antioxidant system, 8-hydroxydeoxyguanosineadduct repair (8-OHdG), and apoptosisin mice exposed to chromium(VI). J Toxicol Environ Heal- Part A Curr Issues [Internet]. 2021;84(8):331-44. Disponibleen: https://doi.org/10.1080/15287394.2020.1867275
Khalaf AA, Moselhy WA, Abdel-Hamed MI. The protectiveeffect of green tea extract on lead induced oxidativeand DNA damage on rat brain. Neurotoxicology.2012;33(3):280-9.