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2022, Number 2

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Rev Cubana Hematol Inmunol Hemoter 2022; 38 (2)

Pediatric sequential multiorgan dysfunction scale: validation in critical pediatric patients with acute lymphocytic leukemia

Figueroa SJA, Rodríguez PLD, Mamposo VJC, Forrellat BM

Language: Spanish
References: 26
Page: 1-13
PDF size: 490.01 Kb.


ABSTRACT

Introduction: Patients admitted to the pediatric intensive care unit (PICU) are those with a high risk of mortality who may present multiple organ dysfunction syndrome. Patients with acute lymphoid leukemia are part of this group.
Objectives: To validate the pediatric sequential multi-organ failure assessment scale (pSOFA) in severe Cuban patients diagnosed with acute lymphoid leukemia.
Methods: An observational, prospective, multicenter study was carried out in intensive care units of Cuban hospitals with 92 patients and 184 admissions. The scores of the sequential multiple organ dysfunction, mortality risk and pediatric mortality index scales were calculated, and the presence of organ dysfunction was evaluated in the first 24 hours and at 48 hours.
Results: The pSOFA score was higher in non-survivors (p <0.001) and mortality progressively increased in the subgroups with the highest pSOFA scores. The analysis of the receiver operating characteristics (ROC) curves showed that the area under the curve (AUC) for the prediction of mortality with the pSOFA score was 0.89, compared to 0.84 and 0.79 with the PRISM-3 and PIM-2 scales, respectively.
Conclusions: The pSOFA scale proved useful to establish the criteria for organ dysfunction and its specificity in the risk of mortality in critical Cuban pediatric patients diagnosed with acute lymphoid leukemia.


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