2024, Number 3
<< Back Next >>
Rev Mex Anest 2024; 47 (3)
Fast track in cesarean sections. Clinical trial to compare tap block versus epidural morphine
Sánchez-Palomo JJ, Esteban-Pizarro N, Calle-Elguezabal P, Gómez-Martínez AM, Brogly N, Santé-Serna L
Language: Spanish
References: 13
Page: 164-168
PDF size: 268.50 Kb.
ABSTRACT
Introduction: there are few studies about fast track protocols in caesarean sections. They recommend peripheral nerve blocks for pain control. Cesarean section causes severe pain. There are analgesic techniques in the literature, but few studies compare them.
Material and methods: 84 patients scheduled for cesarean section were randomized for a triple-blind clinical trial in three parallel groups (TAP, morphine and control). Hypothesis: TAP (transverse abdominal plane) block is not inferiority than epidural morphine. Primary outcome: pain after 24 hours.
Results: pain mean at 24 hours and its standard deviation of the TAP group is 2.86 and 2.01 respectively, while in the morphine group it is 2.9 and 1.88. The mean difference between TAP and morphine is -0.04 (95%CI -1.07; 0.99). Considering that the upper limit of the interval is lower than the established non-inferiority limit, the non-inferiority hypothesis is established. TAP group presented less pain at 6 hours (p = 0.037/95%CI -2.52; -0.08) and walking at discharge (p = 0.001/95%CI -2.36; -0.65), starts walking earlier (p = 0.04/95%CI -2.52; -0.08), causes fewer side effects and improves overall satisfaction than the morphine group.
Conclusions: the TAP block is not inferior to 1 mg epidural morphine for pain control in cesarean sections.
REFERENCES
Carvalho B, Cohen SE, Lipman SS, Fuller A, Mathusamy AD, Macario A. Patient preferences for anesthesia outcomes associated with cesarean delivery. Anesth Analg. 2005;101:1182-1187.
Varadhan KK, Neal KR, Dejong CH, Fearon KC, Ljungqvist O, Lobo DN. The enhanced recovery after surgery (ERAS) pathway for patients undergoing major elective open colorectal surgery: a meta-analysis of randomized controlled trials. Clin Nutr. 2010;29:434-440.
Kehlet H, Wilmore DW. Fast-track surgery. Br J Surg. 2005;92:3-4.
Oderda GM, Gan TJ, Johnson BH, Robinson SB. Effect of opioid-related adverse events on outcomes in selected surgical patients. J Pain Palliat Care Pharmacother. 2013;27:62-70.
Oderda GM, Said Q, Evans RS, Stoddard GJ, Lloyd J, Jackson K, et al. Opioid-related adverse drug events in surgical hospitalizations: impact on costs and length of stay. Ann Pharmacother. 2007;41:400-406.
Kanazi GE, Aouad MT, Abdallah FW, Khatib MI, Adham AM, Harfoush DW, et al. The analgesic efficacy of subarachnoid morphine in comparison with ultrasound-guided transversus abdominis plane block after cesarean delivery: a randomized controlled trial. Anesth Analg. 2010;111:475-481.
Palmer CM, Nogami WM, Van Maren G, Alves DM. Postcesarean epidural morphine: a dose-response study. Anesth Analg. 2000;90:887-891.
Singh SI, Rehou S, Marmai KL, Jones APM. The efficacy of 2 doses of epidural morphine for postcesarean delivery analgesia: a randomized noninferiority trial. Anesth Analg. 2013;117:677-685.
McMorrow RC, Ni Mhuircheartaigh RJ, Ahmed KA, Aslani A, Ng SC, Conrick-Martin I, et al. Comparison of transversus abdominis plane block vs spinal morphine for pain relief after Caesarean section. Br J Anaesth. 2011;106:706-712.
Hebbard PD. Transversalis fascia plane block, a novel ultrasound-guided abdominal wall nerve block. Can J Anaesth. 2009;56:618-620.
Canakci E, Gultekin A, Cebeci Z, Hanedan B, Kilinc A. The analgesic efficacy of transverse abdominis plane block versus epidural block after caesarean delivery: which one is effective? TAP block? Epidural block? Pain Res Manag. 2018;2018:3562701.
Grupo de trabajo de la Guía de Práctica Clínica sobre Cuidados Perioperatorios en Cirugía Mayor Abdominal. Guía de Práctica Clínica sobre Cuidados Perioperatorios en Cirugía Mayor Abdominal. Ministerio de Sanidad, Servicios Sociales e Igualdad. Instituto Aragonés de Ciencias de la Salud (IACS); 2016 Guías de Práctica Clínica en el SNS.
Huang J, Cao C, Nelson G, Wilson RD. A review of enhanced recovery after surgery principles used for scheduled caesarean delivery. J Obstet Gynaecol Can. 2019;41:1775-1788.