medigraphic.com
ISSN 1659-1046 (Print)
Odovtos - International Journal of Dental Sciences

2024, Number 1

<< Back Next >>

Odovtos-Int J Dent Sc 2024; 26 (1)

Is the Use of Ozonated Oil Effective in the Treatment of Oral Lesions? Systematic Review of Clinical Studies

Yabar CJ, Meza-Mauricio J, Mendoza-Azpur G, Castro-Rodríguez Y

Language: English
References: 40
Page: 35-53
PDF size: 594.77 Kb.


ABSTRACT

The aim of this study was to perform a systematic review (SR) of the therapeutic effect of ozonated oil for oral lesions treatment. A SR was conducted according to the PRISMA guidelines. The Medline (PubMed), Embase, Cochrane Library, Scielo and LILACS were investigated, together with manual searches, to extract all publications until December 2020, including randomized and non-randomized clinical trials reporting the effects of ozonated oils on the management of oral lesions when compared with other methods. The risk of bias (RoB) of the studies included were assessed by using the RoB 2 tool and ROBINS-I. After analyzing the titles and reading the abstracts, 1932 articles were excluded; the remaining 25 passed a full-text evaluation. Ultimately, 13 articles were included in this SR. There was heterogeneity of the results regarding healing times and intervals of ozonated oil application for the treatment of each type of oral lesion, but in general, there was a shorter healing time when ozonated oil was used as therapy, and no adverse effects were reported. Despite the limited information found and the lack of rigorous methodological standards for the use of ozonated oil on oral lesions, a positive effect was suggested. The findings indicated an advantage in terms of shorter healing times when compared with other conventional treatments. No adverse effects were reported, showing safety and reliability for patient’s treatment.


REFERENCES

  1. Kramer I.R., Pindborg J.J., Bezroukov V., Infirri J.S. Guide to epidemiology and diagnosis of oral mucosal diseases and conditions. World Health Organization. Community dentistry and oral epidemiology. 1980; 8 (1): 1-26. DOI: 10.1111/j.1600-0528.1980.tb01249.x

  2. El Toum S., Cassia A., Bouchi N., Kassab I. Prevalence and Distribution of Oral Mucosal Lesions by Sex and Age Categories: A Retrospective Study of Patients Attending Lebanese School of Dentistry. International journal of dentistry. 2018; 2018: 4030134. DOI: 10.1155/2018/4030134

  3. Krishna Priya M., Srinivas P., Devaki T. Evaluation of the Prevalence of Oral Mucosal Lesions in a Population of Eastern Coast of South India. Journal of International Society of Preventive & Community Dentistry. 2018; 8 (5): 396-401. DOI: 10.4103/jispcd.JISPCD_207_17

  4. Cruz Quintana S.M., Díaz Sjostrom P., Arias Socarrás D., Mazón Baldeón G.M. Microbiota de los ecosistemas de la cavidad bucal. Revista Cubana de Estomatología. 2017; 54: 84-99.

  5. Martinez-Abreu J., Guerra-Fonten N., Blanco-Garcia A., Naranjo-Rodrigo S., Llanes-Llanes E., Menendez-Cepero S. Efficacy of OLEOZON® compared to Alvogil in the treatment of alveolitis. Journal of Ozone Therapy. 2015. 2015; 1 (1): 1-8.

  6. Tiwari S., Avinash A., Katiyar S., Aarthi Iyer A., Jain S. Dental applications of ozone therapy: A review of literature. The Saudi Journal for Dental Research. 2017; 8 (1): 105-11. http://dx.doi.org/10.1016/j.sjdr.2016.06.005

  7. Martis E., Ekta J. Ozone therapy: A clinical review. Journal of Natural Science, Biology and Medicine. 2011; 2: 66-70. DOI: 10.4103/0976-9668.82319

  8. Díaz Gómez M.F., Ledea Lozano O.E., Gómez Regüeiferio M., Garcés Mancheño R., Alaiz Barragán M.S., Martínez Force E. Estudio comparativo de la ozonización de aceites de girasol modificados genéticamente y sin modificar. Química Nova. 2009; 32: 2467-72. https://doi.org/10.1590/S0100-40422009000900041

  9. Menéndez S., Falcón L., Maqueira Y. Therapeutic efficacy of topical OLEOZON® in patients suffering from onychomycosis. Mycoses. 2011; 54 (5): e272-7. https://doi.org/10.1111/j.1439-0507.2010.01898.x

  10. Travagli V., Zanardi I., Valacchi G., Bocci V. Ozone and Ozonated Oils in Skin Diseases: A Review. Mediators of Inflammation. 2010; 2010: 610418. DOI: 10.1155/2010/610418

  11. Mayor Hernández F., Moure Ibarra M.D., García Valdés M.R. Evolución clínica de las pericoronaritis tratadas con OLEOZON® en urgencias estomatológicas. Revista Médica Electrónica. 2010; 32 (2): 1-7.

  12. Mayor Hernández F., Martínez Abreu J., Moure Ibarra M.D., García Valdés M.R. Aplicación del OLEOZÓN® en el tratamiento de las pericoronaritis. Revista Médica Electrónica. 2011; 33: 75-80.

  13. Rodríguez Corona O., Hernández Sánchez Y. Eficacia del oleozón en el tratamiento de la gingivoestomatitis herpética aguda en pacientes pediátricos. Correo Científico Médico. 2012. 2012; 16 (1): 1-2.

  14. Fontaine Machado O., Fontaine Uliver Md.C., Pérez Alfonzo D.O., Núñez Oduardo E.A., García Jiménez A.M. El Oleozón en el Tratamiento de la Estomatitis Aftosa. Revista Científica Hallazgos 21. 2016; 1 (2): 125-135.

  15. Castillo Betancourt E.O.C.M., Yuniel Hernández J., Castillo Fernandez E. Estomatitis subprotésica y efectividad del oleozón en su tratamiento. RCOE. 2018; 23 (4): 117-123.

  16. Díaz-Couso Y., Arias-Pérez Y., Garrido-Labrada M., Reyes-Nieblas J., Tamayo-Ricardo C.M. Ozonoterapia en pacientes mayores de 12años con estomatitis aftosa recurrente. RevistaElectrónica Dr. Zoilo E. Marinello Vidaurreta;2018; 43 (6): 1-6.

  17. Jiménez López Y., Matos Cantillo D.M., PitaLaborí L.Y., De la Cruz Muguercia M. MatosCantillo C.C. Efectividad del Oleozón®tópico en la estomatitis subprótesis. RevistaInformación Científica. 2018; 97: 261-9.

  18. Souto Román Md.C., Luis Téllez C., RosalesCorria E.N., Gómez Reyes Z. Aplicación delozono en alveolitis dentaria. 2018. 2018; 22(1): 11.

  19. Leal Rodríguez M.I., Leyva Céspedes N.,Zamora Guevara N. Efectividad del oleozónen el tratamiento de la estomatitis aftosarecurrente. Mediciego;2018; 25 (3): 8.

  20. Peña Rosell A., Capote Femenías J.L., JoverCapote N. Utilidad del oleozón tópico en lagingivitis crónica fibroedematosa. RevistaMédica Electrónica. 2019; 41: 54-62.

  21. Alexandrina E., Poroyskiy S., MakedonovaY., Veremeenko S. Efficacy of ozonetherapy in treatment of erosive and ulcerativelesions of oral mucosa. Archivo Euromedica.2020; 10 (2): 67-69. http://dx.doi.org/10.35630/2199-885X/2020/10/2.20

  22. Díaz-Couso Y. Efectividad de la ozonoterapiaen el tratamiento de enfermedades bucalesen pacientes de un área de salud. RevistaElectrónica Dr Zoilo E Marinello Vidaurreta.2020; 45 (5): 1-7.

  23. Moher D., Liberati A., Tetzlaff J., AltmanD.G., Group P. Preferred reporting items forsystematic reviews and meta-analyses: thePRISMA statement. J Clin Epidemiol. 2009;62 (10): 1006-12. https://doi.org/10.1136/bmj.b2535

  24. Shea B.J., Hamel C., Wells G.A., BouterL.M., Kristjansson E., Grimshaw J., et al.AMSTAR is a reliable and valid measurementtool to assess the methodological qualityof systematic reviews. J Clin Epidemiol.2009; 62 (10): 1013-20. DOI: 10.1016/j.jclinepi.2008.10.009

  25. Greenhalgh T., Peacock R. Effectivenessand efficiency of search methods in systematicreviews of complex evidence: auditof primary sources. BMJ. 2005; 331 (7524):1064-5. DOI: 10.1136/bmj.38636.593461.68

  26. Sterne J.A.C., Savović J., Page M.J., ElbersR.G., Blencowe N.S., Boutron I., et al. RoB 2:a revised tool for assessing risk of bias in randomisedtrials. BMJ [Internet]. 2019 2019/08//;366: [l4898 p.]. Available from: http://europepmc.org/abstract/MED/31462531, https://doi.org/10.1136/bmj.l4898.

  27. Sterne J.A., Hernán M.A., Reeves B.C.,Savović J., Berkman N.D., Viswanathan M.,et al. ROBINS-I: a tool for assessing risk ofbias in non-randomised studies of interventions.BMJ. 2016; 355:i4919. doi: https://doi.org/10.1136/bmj.i4919

  28. Wehr C., Cruz G., Young S., Fakhouri W.D.An Insight into Acute Pericoronitis and theNeed for an Evidence-Based Standard ofCare. Dentistry journal. 2019; 7 (3): 88. DOI:10.3390/dj7030088

  29. Alexander R.E. Dental extraction woundmanagement: a case against medicatingpostextraction sockets. J Oral MaxillofacSurg. 2000 May; 58 (5): 538-51. doi: 10.1016/s0278-2391(00)90017-x

  30. Bloomer C.R. Alveolar osteitis prevention byimmediate placement of medicated packing.Oral Surg Oral Med Oral Pathol Oral RadiolEndod. 2000; 90 (3): 282-4. DOI: 10.1067/moe.2000.108919

  31. Taberner-Vallverdú M., Nazir M., Sánchez-Garcés M., Gay-Escoda C. Efficacy of differentmethods used for dry socket management:A systematic review. Medicina oral,patologia oral y cirugia bucal. 2015; 20 (5):e633-9. doi: 10.4317/medoral.20589

  32. Gawron K., łazarz-bartyzel K., Potempa J.,Chomyszyn-Gajewska M. Gingival fibromatosis:Clinical, molecular and therapeuticissues. Orphanet Journal of Rare Diseases.2016; 11: 9.

  33. Huth K., Quirling M., Lenzke S., Paschos E., Kamereck K., Brand K., et al. Effectiveness of ozone against periodontal pathogenic microorganisms. European journal of oral sciences. 2011; 119: 204-10. DOI: 10.1111/j.1600-0722.2011.00825.x

  34. Montevecchi M., Dorigo A., Cricca M., Checchi L. Comparison of the antibacterial activity of an ozonated oil with chlorhexidine digluconate and povidone-iodine. A disk diffusion test. The new microbiologica. 2013; 36 (3): 289-302.

  35. Hilgert J.B., Giordani J.M., de Souza R.F., Wendland E.M., D'Avila O.P., Hugo F.N. Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta-Analysis. Journal of the American Geriatrics Society. 2016; 64 (12): 2539-45. DOI: 10.1111/jgs.14399

  36. Anzolin A.P., da Silveira-Kaross N.L., Bertol C.D. Ozonated oil in wound healing: what has already been proven? Med Gas Res. 2020 Jan-Mar; 10 (1): 54-59. doi: 10.4103/2045-9912.279985

  37. Giannetti L., Murri Dello Diago A., Lo Muzio L. Recurrent aphtous stomatitis. Minerva stomatologica. 2018; 67 (3): 125-8. DOI: 10.23736/S0026-4970.18.04137-7

  38. Cui R.Z., Bruce A.J., Rogers R.S., 3rd. Recurrent aphthous stomatitis. Clinics in dermatology. 2016; 34 (4): 475-81. DOI: 10.1016/j.clindermatol.2016.02.020

  39. Mohan R.P., Verma S., Singh U., Agarwal N. Acute primary herpetic gingivostomatitis. BMJ case reports. 2013; 2013: bcr2013200074.

  40. Goldman R.D. Acyclovir for herpetic gingivostomatitis in children. Can Fam Physician. 2016 May; 62 (5): 403-4.




2020     |     www.medigraphic.com