2022, Number 2
Factors associated with medication non-adherence in patients with type 2 diabetes mellitus
Language: Spanish
References: 36
Page: 412-435
PDF size: 522.78 Kb.
ABSTRACT
Introduction: patients with type 2 diabetes mellitus tend to be poorly adherent to their treatments due to various reasons and factors.Objectives: to present prevalence figures of medication non-adherence in patients with type 2 diabetes mellitus, its associated factors and the most frequently used instruments in the evaluation of this construct.
Methods: a systematic review, whose search criterion was medication adherence in patients with type 2 diabetes mellitus, was carried out. Electronic databases such as EBSCO, PubMed, SciELO, Dialnet, ScienceDirect and Google Scholar were consulted. Articles published in peer-reviewed scientific journals, in Spanish, English and Portuguese languages from 2016 onwards were the established inclusion criteria, as well as intervention studies and those that evaluated the medication adherence in patients with diabetes mellitus together with other chronic diseases were the exclusion criteria.
Conclusions: adherence to pharmacological treatment in patients with type 2 diabetes mellitus is more adequate than non-pharmacological ones. Its evaluation is carried out, fundamentally, through validated tests, where Morisky-Green was the most used test. In the cited studies, medication non-adherence is associated with sociodemographic and socioeconomic factors, related to the complexities of the treatment, with the disease, with difficulties in the doctor-patient relationship and with the presence of negative emotional states. Subjective and behavioral factors such as self-efficacy, self-control and self-regulation have been little studied.
REFERENCES
Rodríguez ML, Rentería A. Factores que impiden la adherencia a un régimen terapéutico en diabéticos: un análisis descriptivo. Psicología y Salud ENT#091;internetENT#093;. 2016 ENT#091;citado 9 ago. 2020ENT#093;;26(1):ENT#091;aprox. 11 p.ENT#093;. Disponible en: https://psicologiaysalud.uv.mx/index.php/psicysalud/article/view/18984.
Maidana G, Lugo G, Vera Z, Acosta P, Morinigo M, Isasi D, Mastroianni P. Factores que determinan la falta de adherencia de pacientes diabéticos a la terapia medicamentosa. Mem Inst Investig Cienc Salud ENT#091;internetENT#093;. 2016 ENT#091;citado 13 sep. 2020ENT#093;;14(1):ENT#091;aprox. 7 p.ENT#093;. Disponible en: https://revistascientificas.una.py/index.php/RIIC/article/view/18475.
Duran J, Barbosa MH, Dos Santos D, Pace AE. Adherence to diabetes mellitus care at three levels of health care. Rev Emferm ENT#091;internetENT#093;. 2017 ENT#091;citado 9 ago. 2020ENT#093;;21(4):ENT#091;aprox. 10 p.ENT#093;. Disponible en: https://www.scielo.br/j/ean/a/MpYFnCP7CLtv7tXpm4PYYvq/?lang=en7.
Martín LA, Grau JA, Espinosa AD. Marco conceptual para la evaluación y mejora de la adherencia a los tratamientos médicos en enfermedades crónicas. Rev Cub Salud Púb ENT#091;internetENT#093;. 2014 ENT#091;citado 13 sep. 2020ENT#093;;40:2:ENT#091;aprox. 6 p.ENT#093;. Disponible en: https://www.scielosp.org/article/rcsp/2014.v40n2/222-238/8.
Ortega JJ, Sánchez D, Rodríguez OA, Ortega JM. Adherencia terapéutica: un problema de atención médica. Acta Méd Grupo Ángeles ENT#091;internetENT#093;. 2018 ENT#091;citado 13 sep. 2020ENT#093;;16(3):ENT#091;aprox. 6 p.ENT#093;. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-720320180003002269.
Dorado MA, Zegbe JA, Castañeda JE. Determinantes psicosociales de la no adherencia terapéutica en pacientes con Diabetes Mellitus tipo 2. IBN SINA ENT#091;internetENT#093;. 2016 ENT#091;citado 13 sep. 2020ENT#093;;7(2):ENT#091;aprox. 16 p.ENT#093;. Disponible en: http://revistas.uaz.edu.mx/index.php/ibnsina/article/view/3010.
Pascasio GD, Ascencio GE, Cruz A, Guzmán CG. Adherencia al tratamiento y conocimiento de la enfermedad en pacientes con DM tipo 2. Salud en Tabasco ENT#091;internetENT#093;. 2016 ENT#091;citado 13 sep. 2020ENT#093;;22(1-2):ENT#091;aprox. 8 p.ENT#093;. Disponible en: https://www.redalyc.org/pdf/487/48749482004.pdf11.
Domínguez LA, Ortega E. Factores asociados a la falta de adherencia al tratamiento en pacientes con DM tipo 2. Rev Soc Parag Med Int ENT#091;internetENT#093;. 2019 ENT#091;citado 13 sep. 2020ENT#093;;6(1):ENT#091;aprox. 9 p.ENT#093;. Disponible en: https://dialnet.unirioja.es/descarga/articulo/6868055.pdf12.
Sánchez JF, Hipólito A, Mugártegui SG, Yáñez RM. Estrés y depresión asociados a la no adherencia al tratamiento en pacientes con DM tipo 2. Atem Fam ENT#091;internetENT#093;. 2016 ENT#091;citado 13 sep. 2020ENT#093;;23(2):ENT#091;aprox. 4 p.ENT#093;. Disponible en: https://www.medigraphic.com/pdfs/atefam/af-2016/af162c.pdf13.
Quiñones A, Ugarte C, Chávez C, Mañalich J. Variables psicológicas asociadas a adherencia, cronicidad y complicaciones en pacientes con DM tipo 2. Rev Méd Chile ENT#091;internetENT#093;. 2018 ENT#091;citado 9 ago. 2020ENT#093;;146(10):ENT#091;aprox. 7 p.ENT#093;.Disponible en: http://dx.doi.org/10.4067/S0034-9887201800100115114.
Ramos Y, Morejón R, Gómez M, Reina M, Rangel C, Cabrera Y. Adherencia terapéutica en pacientes con diabetes mellitus tipo 2. Rev Finlay ENT#091;internetENT#093;. 2017 ENT#091;citado 9 ago 2020ENT#093;;7(2):ENT#091;aprox. 9 p.ENT#093;. Disponible en: http://www.revfinlay.sld.cu/index.php/finlay/article/view/474/157715.
Rincón MK, Torres C, Corredor KA. Adherencia terapéutica en personas con diabetes mellitus tipo 2. Rev Cienc Cuidado ENT#091;internetENT#093;. 2017 ENT#091;citado 24 ago. 2020ENT#093;;14(1):ENT#091;aprox. 19 p.ENT#093;. Disponible en: https://revistas.ufps.edu.co/index.php/cienciaycuidado/article/view/80616.
Aminde LN, Tindong M, Ngwasiri CA, Aminde JA, Njim T, Fondong AA, Takah NF. Adherence to antidiabetic medication and factors associated with non-adherence among patients with type-2 diabetes mellitus in two regional hospitals in Cameroon. Endocrine Disorders ENT#091;internetENT#093;. 2019 ENT#091;citado 24 ago. 2020ENT#093;;19(35):ENT#091;aprox. 8 p.ENT#093;. Disponible en: https://link.springer.com/content/pdf/10.1186/s12902-019-0360-9.pdf17.
Waari G, Mutai J, Gikunju J. Medication adherence and factors associated with poor adherence among type 2 diabetes mellitus patients on follow-up at Kenyatta National Hospital, Kenya. Pan African Medical Journal ENT#091;internetENT#093;. 2018 ENT#091;citado 24 ago. 2020ENT#093;;29(82):ENT#091;aprox. 8 p.ENT#093;. Disponible en: https://www.ajol.info/index.php/pamj/article/view/1769118.
de Oliveira AK, de Oliveira AP, Pinheiro V, Carrera M, Kruze I, Souza R. Fatores associados à adesão terapêutica em idosos diabéticos assistidos na atenção primária de saúde. Ciênc saúde colet ENT#091;internetENT#093;. 2018 ENT#091;citado 24 ago. 2020ENT#093;; 23(3):ENT#091;aprox. 8 p.ENT#093;.Disponible en: https://www.scielo.br/j/csc/a/99bqQY6RQ4hjW43z36R8nnc/?lang=pt19.
Basu S, Garg S, Sharma N, Singh MM, Garg S. Adherence to self-care practices, glycemic status and influencing factors in diabetes patients in a tertiary care hospital in Delhi. World J Diabetes ENT#091;internetENT#093;. 2018 ENT#091;citado 9 ago. 2020ENT#093;;9(5):ENT#091;aprox 6 p.ENT#093;. Disponible en: https://www.wjgnet.com/1948-9358/full/v9/i5/72.htm20.
Shiyanbola OO, Unni E, Huang YM, Lanier C. Using the extended self-regulatory model to characterise diabetes medication adherence: a crosssectional study. BMJ Open ENT#091;internetENT#093;. 2018 ENT#091;citado 9 ago. 2020ENT#093;;8(11):ENT#091;aprox. 8 p.ENT#093;. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30478112/21.
Kokoska A. Treatment adherence in patients with type 2 diabetes mellitus correlates with different coping styles, low perception of self-influence on disease, and depressive symptoms. Patient Prefer Adherence ENT#091;internetENT#093;. 2017 ENT#091;citado 9 ago. 2020ENT#093;;11:ENT#091;aprox. 8 p.ENT#093;. Disponible en: https://pubmed.ncbi.nlm.nih.gov/28360512/22.
Hoogendoorn CJ, Shapira A, Roy JF, Walker EA, Cohen HW, González JS. Depressive symptom dimensions and medication non-adherence in suboptimally controlled type 2 diabetes. J Diabetes Complications ENT#091;internetENT#093; 2019 ENT#091;citado 2 sep. 2020ENT#093;;33(3):ENT#091;aprox. 5 p.ENT#093;. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S1056872718307840?via%3Dihub23.
Bouldin ED, Trivedi RB, Reiber GE, Rosland AM, Silverman JB, Krieger J, et al. Associations between having an informal caregiver, social support, and self-care among lowincome adults with poorly controlled diabetes. Chronic Illn ENT#091;internetENT#093;. 2017 ENT#091;citado 2 sep. 2020ENT#093;;13(4):ENT#091;aprox. 11 p.ENT#093;. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29119864/24.
Halepian L, Saleh MB, Hallit S, Khabbaz LR. Adherence to Insulin, Emotional Distress, and Trust in Physician Among Patients with Diabetes: A Cross-Sectional Study. Diabetes Ther ENT#091;internetENT#093;. 2018 ENT#091;citado 13 sep. 2020ENT#093;;9:ENT#091;aprox. 13 p.ENT#093;. Disponible en: https://link.springer.com/article/10.1007/s13300-018-0389-125.
Acuña G, Huamancayo CA, Guisasola G. Adherencia terapéutica en adultos con diabetes tipo 2 en un programa de enfermedades crónicas. Huánuco 2017. Rev Perú Investig Salud ENT#091;internetENT#093;. 2019 ENT#091;citado 13 sep. 2020ENT#093;;3(4):ENT#091;aprox. 5 p.ENT#093;. Disponible en: https://revistas.upch.edu.pe/index.php/RMH/article/view/318126.
Hermoza RD, Matellini BM, Rosales AJ, Noriega VH. Adherencia a terapia médica nutricional en pacientes con diabetes mellitus tipo 2, de un hospital nacional de nivel III en Lima, Perú. Rev Med Hered ENT#091;internetENT#093;. 2017 ENT#091;citado 24 ago. 2020ENT#093;;28(3):ENT#091;aprox. 6 p.ENT#093;. Disponible en: https://revistas.upch.edu.pe/index.php/RMH/article/view/318127.
Ramírez MC, Anlehu A, Rodríguez A. Factores que influyen en el comportamiento de adherencia del paciente con DM tipo 2. Horizonte sanitario ENT#091;internetENT#093;. 2019 ENT#091;citado 13 sep. 2020ENT#093;;18(3):ENT#091;aprox. 9 p.ENT#093;. Disponible en: https://dialnet.unirioja.es/servlet/articulo?codigo=744508028.
Ramos LE. La adherencia al tratamiento en las enfermedades crónicas. Rev Cubana Angiol Cir Vasc ENT#091;internetENT#093;. 2015 ENT#091;citado 13 sep. 2020ENT#093;;16(2):ENT#091;aprox. 14 p.ENT#093;. Disponible en: http://scielo.sld.cu/scielo.php?pid=S1682-00372015000200006&script=sci_arttext&tlng=pt29.
Reina MM, Martínez CA. Barreras de la adherencia al tratamiento en pacientes diabéticos. Cina Research ENT#091;internetENT#093;. 2019 ENT#091;citado 13 sep. 2020ENT#093;;3(2):ENT#091;aprox. 6 p.ENT#093;.Disponible en: https://journals.uninavarra.edu.co/index.php/cinaresearch/article/download/182/8130.
Limaylla ML, Ramos NJ. Métodos indirectos de valoración del cumplimiento terapéutico. Ciencia e Investigación ENT#091;internetENT#093;. 2016 ENT#091;citado 13 sep. 2020ENT#093;;19(2):ENT#091;aprox. 6 p.ENT#093;. Disponible en: https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/1363531.
Horne R, Weinman J. Self-regulation and self-management in asthma: exploring the role of illness perceptions and treatment beliefs in explaining non-adherence to preventer medication. Psychol Health ENT#091;internetENT#093;. 2010 ENT#091;citado 2 sep. 2020ENT#093;;17:ENT#091;aprox. 15 p.ENT#093;. Disponible en: https://www.tandfonline.com/doi/abs/10.1080/0887044029000150232.
Polonsky WH, Henry RR. Poor medication adherence in type 2 diabetes: recognizing the scope of the problem and its key contributors. Patient Prefer Adherence ENT#091;internetENT#093;. 2016 ENT#091;citado 13 sep. 2020ENT#093;;10:ENT#091;aprox. 8 p.ENT#093;. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27524885/34.
Habte BM, Kebede T, Fenta TG, Boon H. Barriers and facilitators to adherence to anti-diabetic medications: Ethiopian patients' perspectives. Afr J Prm Health Care Fam Med ENT#091;internetENT#093;. 2017 ENT#091;citado 24 ago. 2020ENT#093;;9(1):ENT#091;aprox 8 p.ENT#093;. Disponible en: https://phcfm.org/index.php/phcfm/article/view/141135.