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2023, Number 3

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Rev Hematol Mex 2023; 24 (3)

L-asparaginase in the treatment of acute lymphoblastic leukemia, its adverse effects, and opportunities for treatment optimization

Gándara MJA, Lares AI, Reyes EEA, Córdova HLP, Reyes GFM, Sandoval CA, Loera CV, Díaz GC, García VA, Nava RAR, Patrón RL, Almanza RH

Language: Spanish
References: 97
Page: 145-162
PDF size: 713.69 Kb.


ABSTRACT

Treatment of acute lymphoblastic leukemia has improved over the years due to the development of increasingly effective treatment strategies. L-asparaginase (L-Asp) is one of the main drugs used in the treatment of acute lymphoblastic leukemia whose therapeutic objective is to systematically deplete the non-essential amino acid asparagine (Asp) and thus cause the death of leukemia cells; however, the hypersensitivity reactions and pancreatitis are the main adverse effects associated with this medication. A review of the literature was carried out based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology in Redalyc, SciELO, ScienceDirect, PubMed, BVS Medline and SCOPUS databases, with the aim of describing the advances in the treatment with L-Asp against acute lymphoblastic leukemia, its adverse effects and opportunities in treatment optimization. In the first instance, a total of 607 articles that talked about aspects of L-Asp were obtained, a selection of 97 articles that provided answers to our objectives of this review. According to this review, the ability to indi- Convidualize therapy, adjust the dose, or change the formulation of L-Asp may help reduce adverse effects, as well as identify patients with silent inactivation and thus improve the quality of life, safety and efficacy in pediatric patients with acute lymphoblastic leukemia under treatment with L-Asp.


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