Ceballos RG, Ramírez SI, Calzada-Mendoza CC, Olivares-Corichi IM

Language: Spanish
References: 19
Page: 233-236
PDF size: 103.84 Kb.

ABSTRACT

In the vascular endothelium to cross molecules, the blood coagulation is carried out, the production of vasoactives agents and angiogenic process. This functions are realized with the participation of substances circulating or in situ synthesized. Recently, has been found that free radicals can modulate the activity of endothelium and it is unclear if these are cause or consequence of pathologies relationed with vascular system. In diseases such as atherosclerosis, diabetes and hypertension include vascular endothelium dysfunction, which is related with free radical and reactive oxygen, nitrogen and chlorine species. The source of those species can be NADP(P)H-oxidase, xantine oxidase, nitric oxide synthase, mieloperoxidase, lipooxygenase, mitochondrial metabolism and transition metals. To determinate of reactive species can be through direct identification of free radical using electron paramagnetic resonance, assessing damage produced and measuring antioxidant capacity. All of these tests have acquired importance like tools in chronic degenerative diseases assessment.

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