Ramírez-Alfaro JÁ, Cerón-Díaz UW

Language: Spanish
References: 17
Page: 662-665
PDF size: 174.51 Kb.

ABSTRACT

Introduction: the lactate/albumin index (I-L/A) has been proposed as a useful and simple tool to predict mortality in patients with septic shock. Objective: determine the predictive mortality capacity of the I-L/A in patients with septic shock. Material and methods: a retrospective cohort study of patients admitted to the Intensive Care Unit (ICU) was conducted with the diagnosis of septic shock. The information was obtained from the ICU database. The prognostic performance of the lactate/albumin index compared to SAPS III and SOFA was analyzed. Results: we included 334 patients with septic shock; 190 (56.9%) male patients with a mean age of 69.6 ± 14.1 years. The AUC was 0.790 (95% CI, 0.742-0.838), 0.742 (95% CI, 0.690-0.795) and 0.669 (95% CI, 0.611-0.727) for I-L/A, SOFA, SAPS III respectively. The best cut-off point for I-L/A was 0.79, with a sensitivity of 80% and a specificity of 68%. Conclusions: the I-L/A is a tool with good discriminatory ability to predict mortality in patients with septic shock.

REFERENCES

1. Masson S, Caironi P, Spanuth E, Thomae R, Panigada M, Sangiorgi G, et al. Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from de albumin italian outcome sepsis trial. Crit Care. 2014;18:R6. Available in: http://ccforum.com/content/18/1/R6

2. Shin J, Hwang SY, Jo IJ, Kim WY, Ryoo SM, Kang GY, et al. Prognostic value of the lactate albumin ratio for predicting 28-day mortality in critically ill sepsis patients. Shock. 2018;50(5):545-550. doi: 10.1097/SHK.0000000000001128.

3. Thapa S, Prasad PN, Shakya YM. Serum Lactate Albumin Ratio as a predictor of Mortality in severe sepsis and septic shock at Tribhuwam University Teaching Hospital, Kathmandu. BJHS. 2017;2(2):191-195.

4. Lu Y, Guo H, Chen X, Zhang Q. Association between lactate/albumin ratio and all-cause mortality in patients with acute respiratory failure: a retrospective analysis. PLoS ONE. 2021;16(8):e0255744.

5. Chow-Quezada JM. Índice lactato/albúmina como predictor de mortalidad en sepsis y choque séptico en pacientes ingresados a Cuidados Intensivos, Hospital Escuela Dr. Manolo Morales Peralta, Nicaragua, Enero-Diciembre 2021. Rev Panam Enf Inf. 2021;2(2): e3.

6. Bou-Chebl R, Jamali S, Sabra M, Safa R, Berbari I, Shami A, et al. Lactate/albumin ratio as a predictor of in-hospital mortality in septic patients presenting to the emergency department. Front Med. 2020;7:550182.

7. Shadvar K, Nader-Djalal N, Vahed N, Sanaie S, Iranpour A, Mahmoodpoor A, et al. Comparison of lactate/albumin ratio to lactate and lactate clearance for predicting outcomes in patients with septic shock admitted to intensive care unit: an observational study. Scientific Reports. 2022;12:13047.

8. Kabra R, Acharya S, Shukla S, Kumar S, Wanjari A, Mahajan S, et al. Serum Lactate-Albumin ratio: soothsayer for outcome in sepsis. Cureus. 2023;15(3):e36816.

9. Cakir E, Turan IO. Lactate/albumin ratio is more effective than lactate or albumin alone in predicting clinical outcomes in intensive care patients with sepsis. Scand J Clin Lab Invest. 2021;81(3):225-229.

10. Yucel K, Gurbuz AF. The effect of lactate/albumin ratio on mortality in patients with sepsis. Med Science. 2021;10(3):939-45.

11. Albee, Prasad A, Tripathi T, Khan MJ. Lactate albumin ratio in comparison with lactate to predict outcomes in sepsis and septic shock. International Journal of Science and Research. 2023;12(3):851-853.

12. Li F, Ye Z, Zhu J, Gu S, Peng S, Fang Y, et al. Early lactate/albumin and procalcitonin/albumin ratio as predictors of 28-day mortality in ICU-admitted sepsis patients: a retrospective cohort study. Med Sci Monit. 2023;29:e940654.

13. Trujillo-Ramírez N, López-Reséndiz SM, Méndez-Reyes R, Villagómez-Ortíz AJ, Rosas-Barrientos JV. Índice de lactato/albúmina como predictor de mortalidad en sepsis y choque séptico. Med Crit. 2018;32(3):136-140.

14. Wolfertz N, Bohm L, Keitel V, Hannappwel O, Kümpers P, Bernhard M, et al. Epidemiology, management, and outcome of infection, sepsis, and septic shock in a German emergency department (EpiSEP study). Front Med (Lausanne). 2022;9:997992. doi: 10.3389/fmed.2022.997992.

15. Mulatu HA, Bayisa T, Worku Y, Lazarus JJ, Woldeyes E, Bacha D, et al. Prevalence and outcome of sepsis and septic shock in intensive care units in Addis Adaba, Ethiopia: a prospective observational study. Afr J Emerg Med. 2021;11(1):188-195.

16. Madkour AM, ELMaraghy AA, Elsayed MM. Prevalence and outcome of sepsis in respiratory intensive care unit. Egypt J Bronchol. 2022;16:29.

17. Wang R, He M, Qu F, Zhang J and Xu J. Lactate albumin ratio is associated with mortality in patients with moderate to severe traumatic brain injury. Front Neurol. 2022;13:662385.