Quezada PMV, Sánchez ZMJ

Language: Spanish
References: 9
Page: 610-613
PDF size: 205.79 Kb.

ABSTRACT

Diffuse alveolar hemorrhage is a rare entity with high mortality. Clinically it is characterized by severe dyspnea that is accompanied by hypoxemia, decreased hemoglobin, and hemoptysis. The most frequent causes are vasculitis, rheumatological, pharmacological diseases, elevation of left ventricular pressure (heart failure), among others. The clinical case of a 26-year-old man with diagnoses of lupus erythematosus, antiphospholipid syndrome, chronic pulmonary thromboembolism, and chronic heart failure and over coagulation syndrome who develops diffuse alveolar hemorrhage and high-risk pulmonary thromboembolism is described, in order to exemplify the challenges for the treatment of diffuse alveolar hemorrhage.

REFERENCES

1. Jiang H, Wang CH, Jiang N, Li J, Wu CY, Wang Q, et al. Clinical characteristics and prognosis of patients with isolated thrombotic vs. obstetric antiphospholipid syndrome: a prospective cohort study. Arthritis Res Ther. 2021;23(1):138. doi: 10.1186/s13075-021-02515-w.

2. Aguilera-Pickens G, Abud-Mendoza C. Manifestaciones pulmonares en lupus eritematoso sistémico: afección pleural, neumonitis aguda, enfermedad intersticial crónica y hemorragia alveolar difusa. Reumatol Clin. 2018;14:294-300.

3. Al-Adhoubi NK, Bystrom J. Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies. Lupus. 2020;29(4):355-363.

4. Scapa JV, Fishbein GA, Wallace WD, Fishbein MC. Diffuse alveolar hemorrhage and pulmonary vasculitides: histopathologic findings. Semin Respir Crit Care Med. 2018;39(4):425-433. doi: 10.1055/s-0038-1669412.

5. Park JA. Treatment of diffuse alveolar hemorrhage: controlling inflammation and obtaining rapid and effective hemostasis. Int J Mol Sci. 2021;22(2):793. doi: 10.3390/ijms22020793.

6. Nasser M, Cottin V. Alveolar hemorrhage in vasculitis (primary and secondary). Semin Respir Crit Care Med. 2018;39(4):482-493. doi: 10.1055/s-0038-1668533.

7. Martínez-Martínez MU, Ostdam DAH, Abud-Mendoza C. Diffuse alveolar hemorrhage in autoimmune diseases. Curr Rheumatol Rep. 2017;19:27. doi: 10.1007/s11926-017-0651-y.

8. Ednalino C, Yip J, Carsons SE. Systematic review of diffuse alveolar hemorrhage in systemic lupus erythematosus: focus on outcome and therapy. J Clin Rheumatol. 2015;21(6):305-310.

9. Reibaldi AA, Sager L, Calvo R, Ortiz A, Roverano S, Paira S, et al. Hemorragia alveolar difusa en pacientes con lupus eritematoso sistémico. Reumatol Clin. 2022;18:84-90.