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ISSN 2448-8909 (Print)

2023, Number 7

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Med Crit 2023; 37 (7)

CRP/PCT ratio as a mortality predictor of septic shock in the intensive care unit

Martha MVA, Zárate RC, Sánchez CA, Martínez DBA, Aguirre SJS

Language: Spanish
References: 15
Page: 573-581
PDF size: 281.22 Kb.


ABSTRACT

Introduction: sepsis is defined as a syndrome comprised of pathological and biochemical abnormalities induced by infection, that could cause a systemic inflammatory response that could cause organ dysfunction, known as severe sepsis; such alterations could culminate in septic shock when associated with refractory hypotension, which persists after adequate fluid administration. Direct relationship between C reactive protein (CPR) and procalcitonin (PCT) with mortality is controversial. The objective of this study is to examine the relationship between CPR/PCT index (C reactive protein and procalcitonin index) and observed mortality in patients with septic shock. Material and methods: in an observational, retrospective study, we included patients that were admitted to the Intensive Care Unit (ICU) between January 2022 and March 2023 with diagnosis of septic shock. Included variables were age, sex, presence of comorbidities, leucocyte count, serum lactate levels, creatinine, C reactive protein, procalcitonin and with these calculated the CPR/PCT index. Using the χ2 test, we calculated the odds ratio of each variable with mortality. Results: 142 patients were included, with an observed mortality of 20.4%, with the respiratory and urinary tracts as the most predominant infection sites. Average C reactive protein levels were 15.42 (IQR 25.75: 5.55, 23), median procalcitonin levels were 1.86 (IQR 0.44, 17.6), median CPR/PCT index was 3.64 (IQR 0.98, 21.13). An CPR/PCT index less than 3.64 relates to higher mortality levels (OR 2.22, CI 95% 0.95-5.21). Conclusions: a relationship of lower levels of the CPR/PCT index and higher mortality rates was described in patients with septic shock, suggesting that we it could be used as a tool to predict mortality at ICU admission.


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