Association between dysnatremias and mortality in patients with invasive mechanical ventilation due to ARDS secondary to COVID-19

Jorge Lozano García; Jesús Salvador Sánchez Díaz; Karla Gabriela Peniche Moguel; Erik Canseco González; Diego Escarramán Martínez; María Verónica Calyeca Sánchez

2023, Number 7

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Med Crit 2023; 37 (7)

Association between dysnatremias and mortality in patients with invasive mechanical ventilation due to ARDS secondary to COVID-19

Lozano GJ, Sánchez DJS, Peniche MKG, Canseco GE, Escarramán MD, Calyeca SMV

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How to cite this article

10.35366/114854

Language: Spanish
References: 17
Page: 542-546
PDF size: 214.77 Kb.

ABSTRACT

Introduction: hyponatremia prevails in up to 44% of patients with coronavirus disease 2019 (COVID-19), with levels varying depending on the severity of the disease. In acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), high levels of IL-6 favor the non-osmotic secretion of vasopressin, this can cause hyponatremia to coexist, being a marker of illness. forecast. AIM. Objective: to evaluate the association between dysnatremia and mortality in patients with invasive mechanical ventilation (IMV) due to ARDS secondary to COVID-19. Material and methods: cohort, retrospective, observational and analytical study. It was carried out in the Intensive Care Unit (ICU) between May 1, 2020 and December 31, 2022. It consisted of reviewing the medical records of patients who met the inclusion criteria. They were classified according to the outcome: survivor and non-survivor. Results: 92 patients were included; the surviving group included 40 patients and 52 non-surviving patients. The mean SAPS II score was 72 and 80 points (p = 0.004) for the survivor and non-survivor group, respectively. The OR of sodium disorders was calculated, highlighting hyponatremia as a risk factor for mortality OR 4.35 (95% CI 1.10-17.09) with p = 0.03 with AUC 0.86 (95% CI 0.79-0.93; p = 0.001). Conclusion: hyponatremia upon admission to the ICU is an independent risk factor for mortality in patients with IMV due to ARDS secondary to COVID-19.

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