medigraphic.com
ISSN 1561-3119 (Electronic)

2022, Number 1

<< Back Next >>

Rev Cubana Pediatr 2022; 94 (1)

Factors associated with prolonged hospitalization in infants with moderate bronchiolitis

Cerdán RSL

Language: Spanish
References: 31
Page: 1-14
PDF size: 1169.35 Kb.


ABSTRACT

Introduction: Bronchiolitis is a clinical entity that occurs before the age of two and is a frequent cause of hospitalization in this age group. Prolonged hospitalization is defined as a hospital time greater than 5 days. This situation demands the use of resources and has an economic impact on the health system. In the Peruvian context, the factors associated with prolonged hospitalization in patients with bronchiolitis have not been addressed.
Objective: etermine the factors associated with prolonged hospitalization in patients with moderate bronchiolitis.
Method: Descriptive, cross-sectional, retrospective study. The unit of analysis was the clinical history of infants hospitalized due to moderate bronchiolitis treated at Niño -Breña National Institute of Health, between 2018 and 2019. 160 infants were included. To establish the relationship between the factors associated with prolonged hospitalization of both the mother and the clinical aspects of the infant, the JI-square test with a significance level of 0.05 was used.
Results: rolonged hospitalization was associated with a greater number of days with supplemental oxygen with p= 0.000; in addition to presenting more frequently in infants who did not receive exclusive breastfeeding with p = 0.000 . Finally, it was also associated with atelectasis and pneumonia, both cases with p= 0.040.
Conclusions: Prolonged hospitalization in infants with bronchiolitis is associated with the number of days on supplemental oxygen, with the non-enjoyment of exclusive breastfeeding and with the appearance of complications such as bronchiectasis and pneumonia.


REFERENCES

  1. Plint AC, Johnson DW, Patel H, Wiebe N, Correll R, Brant R, et al. Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med. 2009;360(20):2079-89. DOI: 10.1056/NEJMoa0900544

  2. Hall CB, Weinberg GA, Iwane MK, Blumkin AK, Edwards KM, Staat MA, et al. The burden of respiratory syncytial virus infection in young children. N Engl J Med. 2009;360(6):588-98. DOI: 10.1056/NEJMoa0804877

  3. Mezarina Esquivel HA, Rojas Medina AR, Bada Mancilla CA, Castañeda Campozano RE, Carhuancho Aguilar JR. Características clínicas y epidemiológicas de la infección respiratoria aguda grave por virus sincitial respiratorio en menores de 5 años. Horizonte Méd. (Lima). 2016 [acceso 26/10/2021];16(3):6-11. Disponible en: Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1727-558X2016000300002&lng=es

  4. Rodríguez-Martínez CE, Sossa-Briceño MP, Nino G. Predictors of prolonged length of hospital stay for infants with bronchiolitis. J Investig Med Off Publ Am Fed Clin Res. 2018;66(6):986-91. DOI: 10.1136/jim-2018-000708

  5. Díez Domingo J, Ridao López M, Úbeda Sansano I, Ballester Sanz A. Incidencia y costes de la hospitalización por bronquiolitis y de las infecciones por virus respiratorio sincitial en la Comunidad Valenciana. Años 2001 y 2002. An Pediatr. 2006;65(4):325-30. DOI: 10.1157/13093515

  6. Woll C, Neuman MI, Aronson PL. Management of the Febrile Young Infant: Update for the 21st Century. Pediatr Emerg Care. 2017;33(11):748-53. DOI: 10.1097/PEC.0000000000001303

  7. Zaidi AKM, Thaver D, Ali SA, Khan TA. Pathogens Associated With Sepsis in Newborns and Young Infants in Developing Countries. Pediatr Infect Dis J. 2009;28(Suppl.):S10-8. DOI: 10.1097/INF.0b013e3181958769

  8. Vincent JO, Lo H-Y, Wu S. Bronchiolitis Care in the Hospital. Rev Recent Clin Trials. 2017;12(4):246-52. DOI:10.2174/1574887112666170816152832

  9. Midulla F, Petrarca L, Frassanito A, Di Mattia G, Zicari AM, Nenna R. Bronchiolitis clinics and medical treatment. Minerva Pediatr. 2018;70(6):600-11. DOI : 10.23736/S0026-4946.18.05334-3

  10. Joseph MM, Edwards A. Acute bronchiolitis: assessment and management in the emergency department. Pediatr Emerg Med Pract. 2019 [acceso 26/10/2021];16(10):1-24. Disponible en: Disponible en: https://www.ebmedicine.net/topics/respiratory/pediatric-bronchiolitis

  11. Lopez J. Estancia hospitalaria y manejo de bronquiolitis aguda con suero hipertónico vs suero fisiológico en lactantes menores de 2 años del Hospital María Auxiliadora, 2011-2018. Lima, Perú: Universidad Nacional Mayor de San Marcos; 2019 [acceso 26/10/2020]. Disponible en: Disponible en: https://cybertesis.unmsm.edu.pe/bitstream/handle/cybertesis/10375/Lopez_vj.pdf?sequence=1&isAllowed=y

  12. Silver AH, Nazif JM. Bronchiolitis. Pediatr Rev. 2019;40(11):568-76. DOI: 10.1542/pir.2018-0260

  13. Muñoz-Quiles C, López-Lacort M, Úbeda-Sansano I, Alemán-Sánchez S, Pérez-Vilar S, Puig-Barberà J, et al. Population-based Analysis of Bronchiolitis Epidemiology in Valencia, Spain. Pediatr Infect Dis J. 2016;35(3):275-80. DOI: 10.1097/INF.0000000000000993

  14. Meissner HC. Viral Bronchiolitis in Children. NEJM. 2016;374(1):62-72. DOI: 10.1056/NEJMra1413456

  15. Valla FV, Baudin F, Demaret P, Rooze S, Moullet C, Cotting J, et al. Nutritional management of young infants presenting with acute bronchiolitis in Belgium, France and Switzerland: survey of current practices and documentary search of national guidelines worldwide. Eur J Pediatr. 2019;178(3):331-40. DOI : 10.1007/s00431-018-3300

  16. El Basha N, Marzouk H, Sherif M, El Kholy A. Prematurityis a significant predictor ofworseoutcomes in viral bronchiolitis: A comparative study in infancy. J Egypt Public Health Assoc. 2017;92(3):188-94. DOI: 6.10.21608/EPX.2018.16152

  17. Nenna R, Cutrera R, Frassanito A, Alessandroni C, Nicolai A, Cangiano G, et al. Modificable risk factors associated with bronchiolitis. Ther Adv Respir Dis. 2017;11(10):393-401. DOI: 10.1177/1753465817725722

  18. Argimon Pallás JM, Jiménez Villa J. Métodos de investigación clínica y epidemiológica. 4ta. ed. Barcelona, España: Elsevier; 2013.

  19. Ministerio de Salud del Perú. Guía de Práctica Clínica para el diagnóstico y tratamiento de bronquiolitis en niños menores de 2 años 2019. Perú: Minsa; 2019 [acceso 02/11/2020]. Disponible en: Disponible en: http://bvs.minsa.gob.pe/local/MINSA/4930.pdf

  20. Gonzales L, Jimena M. Lactancia materna parcial y nivel socioeconómico bajo como factores de riesgo para la hospitalización por bronquiolitis en lactantes menores de 6 meses. Trujillo, Perú: Universidad Nacional de Trujillo; 2015 [acceso 02/11/2018]. Disponible en: Disponible en: http://dspace.unitru.edu.pe/handle/UNITRU/1114

  21. Declaración de Helsinki de la Asociación Médica Mundial. Principios éticos para las investigaciones médicas en seres humanos. 64a Asamblea General. Helsinki: Asociación Médica Mundial; 2013 [acceso 28/03/2020]. Disponible en: Disponible en: http://www.bioeticayderecho.ub.edu/es/64a-asamblea-general-de-la-declaracion-de-helsinki-de-la-amm-principios-eticos-para-las

  22. Cunningham S, Rodriguez A, Adams T, Boyd KA, Butcher I, Enderby B, et al. Oxygensaturation targets in infants with bronchiolitis (BIDS): a double-blind, randomised, equivalence trial. Lancet Lond Engl. 2015;386(9998):1041-8. DOI:10.1016/S0140-6736(15)00163-4

  23. Schroeder AR, Marmor AK, Pantell RH, Newman TB. Impact of Pulse Oximetry and Oxygen Therapy on Length of Stay in Bronchiolitis Hospitalizations. Arch Pediatr Adolesc Med. 2004;158(6):527. DOI:10.1001/archpedi.158.6.527

  24. Semple MG, Taylor-Robinson DC, Lane S, Smyth RL. Household Tobacco Smoke and Admission Weight Predict Severe Bronchiolitis in Infants Independent of Deprivation: Prospective Cohort Study. PLoS ONE. 2011;6(7):e22425. DOI: 10.1371/journal.pone.0022425

  25. Lanari M, Prinelli F, Adorni F, Di Santo S, Vandini S, Silvestri M, et al. Risk factors for bronchiolitis hospitalization during the first year of life in a multicenter Italian birth cohort. Ital J Pediatr. 2015;41:40. DOI: 10.1186/s13052-015-0149-z

  26. Lanari M, Prinelli F, Adorni F, Di Santo S, Faldella G, Silvestri M, et al. Maternal milk protects infants against bronchiolitis during the first year of life. Results of roman Italian cohort of new borns. Early Hum Dev. 2013;89 Suppl1:S51-57. DOI: 10.1016/S0378-3782(13)70016-1

  27. Willson DF, Landrigan CP, Horn SD, Smout RJ. Complications in infants hospitalized for bronchiolitis or respiratory syncytial virus pneumonia. J Pediatr. 2003;143(5 Suppl.):S142-149. DOI: 10.1067/S0022-3476(03)00514-6

  28. Merkus PJFM, Hoog M de, Gent R van, Jongste JC de. DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. Eur Respir J. 2001;18(4):734-7.

  29. Robledo-Aceves M, Moreno-Peregrina M de J, Velarde-Rivera F, Ascencio-Esparza E, Preciado-Figueroa FM, Caniza MA, et al. Risk factors for severe bronchiolitis caused by respiratory virus infections among Mexican children in an emergency department. Medicine (Baltimore). 2018;97(9):e0057. DOI: 10.1097/MD.0000000000010057

  30. Shang X, Liabsuetrakul T, Sangsupawanich P, Xia X, He P, Cao H. Elective cesarean ndelivery as a predisposing factor of respiratory syncytial virus bronchiolitis in children [abstract]. J Med Assoc Thai. 2014 [acceso 26/10/2021];97(8):827-34. Disponible en: Disponible en: https://www.pubmed.ncbi.nlm.nih.gov/25345258/

  31. Hendaus MA, Alhammadi AH, Khalifa MS, Muneer E. Does cesarean section pose a risk of respiratory syncytial virus bronchiolitis in infants and children? Asian Pac J Trop Med. 2014;7:S134-6. DOI: 10.1016/S1995-7645(14)60219-4




2020     |     www.medigraphic.com