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Organo Oficial de la Sociedad Mexicana de Urología

2023, Number 6

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Rev Mex Urol 2023; 83 (6)

Erectile dysfunction and viral infections: a narrative review

López-Daza JJ, Manotas-Murillo FG, Lambis-Ricardo J, Márquez-Lázaro J

Language: Spanish
References: 48
Page: 1-14
PDF size: 340.49 Kb.


ABSTRACT

Description of the topic: Erectile dysfunction is a prevalent condition among the male population and can result from various factors such as hormonal, metabolic, infectious, or anatomical issues. Infections caused by viruses such as Human Immunodeficiency Virus (HIV), Herpes Simplex Virus, Varicella-Zoster Virus, Human Papillomavirus (HPV), Human T-lymphotropic Virus type 1 (HTLV-1), Dengue virus, and SARS-CoV-2 have been found to be associated with erectile dysfunction through different physiological mechanisms. In many cases, these infections interact with the immune system, leading to the development of a localized or generalized inflammatory response of varying intensity.
Relevance: Certain viral infections can directly affect the tissues of the male reproductive system, resulting in erectile dysfunction. These infections can damage the nerves and blood vessels that are essential for achieving and maintaining an erection.
Conclusion: Erectile dysfunction is of multifactorial origin, and according to the reviewed literature it can be triggered by some vascular sequelae induced by viral infections, including those produced by the acquired immunodeficiency virus (HIV), herpes simplex virus, zoster, human papilloma (HPV), human lymphotropic virus type I (HTL1), Dengue and SARS-CoV2.


REFERENCES

  1. López-Torres Hidalgo J. La detección de lasdisfunciones sexuales en Atención Primaria.Atencion Primaria. 2012;44(9): 525–526.https://doi.org/10.1016/j.aprim.2012.06.002.

  2. Reino DMM, Cárdenas JPT. Prevalencia ycaracterización de disfunciones sexualesmasculinas en el personal de la Unidad académicade Salud y Bienestar de la Universidad Católicade Cuenca, año 2019. Revista de la Facultad deCiencias Médicas de la Universidad de Cuenca.2020;38(1): 53–63. https://doi.org/: https://doi.org/10.18537/RFCM.38.01.08.

  3. Corona G. Erectile dysfunction and prematureejaculation: a continuum movens supportingcouple sexual dysfunction. Journal ofEndocrinological Investigation. 2022;45(11):2029–2041. https://doi.org/10.1007/s40618-022-01793-8.

  4. Kapoor R, Kapoor A. Erectile dysfunction: Apresent day coronary disease risk equivalent.Indian Journal of Medical Research. 2016;144(3):307. https://doi.org/10.4103/0971-5916.198669.

  5. Pallangyo P, Nicholaus P, Kisenge P, Mayala H,Swai N, Janabi M. A community-based study onprevalence and correlates of erectile dysfunctionamong Kinondoni District Residents, DarEs Salaam, Tanzania. Reproductive Health.2016;13(1): 140. https://doi.org/10.1186/s12978-016-0249-2.

  6. Miyata Y, Matsuo T, Nakamura Y, MitsunariK, Ohba K, Sakai H. Pathological Significanceof Macrophages in Erectile DysfunctionIncluding Peyronie’s Disease. Biomedicines.2021;9(11): 1658. https://doi.org/10.3390/biomedicines9111658.

  7. Hashimoto D, Hirashima T, YamamuraH, Kataoka T, Fujimoto K, Hyuga T, et al.Dynamic erectile responses of a novel penileorgan model utilizing TPEM†. Biology ofReproduction. 2021;104(4): 875–886. https://doi.org/10.1093/biolre/ioab011.

  8. Yafi FA, Jenkins L, Albersen M, CoronaG, Isidori AM, Goldfarb S, et al. Erectiledysfunction. Nature Reviews Disease Primers.2016;2(1): 16003. https://doi.org/10.1038/nrdp.2016.3.

  9. Gómez-Barrios JV, Gómez ME. Inhibidoresde la 5-Fosfodiesterasa (PDE-5i): Una futuraalternativa para el manejo de la aterosclerosis.AVFT – Archivos Venezolanos de Farmacología yTerapéutica. 2019;38(2).

  10. Matsui H, Sopko N, Hannan J, BivalacquaT. Pathophysiology of Erectile Dysfunction.Current Drug Targets. 2015;16(5): 411–419.https://doi.org/10.2174/138945011605150504114041 Actions.

  11. Hsieh TC, Edwards NC, Bhattacharyya SK,Nitschelm KD, Burnett AL. The Epidemic ofCOVID-19-Related Erectile Dysfunction: AScoping Review and Health Care Perspective.Sexual Medicine Reviews. 2022;10(2): 286–310.https://doi.org/10.1016/j.sxmr.2021.09.002.

  12. Tolouian R, Vahed SZ, Ghiyasvand S, TolouianA, Ardalan M. COVID-19 interactions withangiotensin-converting enzyme 2 (ACE2)and the kinin system; looking at a potentialtreatment. Journal of Renal Injury Prevention.2020;9(2): e19–e19. https://doi.org/10.34172/jrip.2020.19.

  13. Kaynar M, Gomes ALQ, Sokolakis I, Gül M.Tip of the iceberg: erectile dysfunction andCOVID-19. International Journal of ImpotenceResearch. 2022;34(2): 152–157. https://doi.org/10.1038/s41443-022-00540-0.

  14. Guo J, Sheng K, Wu S, Chen H, Xu W. AnUpdate on the Relationship of SARS-CoV-2 andMale Reproduction. Frontiers in Endocrinology.2021;12: 788321. https://doi.org/10.3389/fendo.2021.788321.

  15. José FG, González JGÁ, Molina JMC, ArnauLB, Iribarren IM, Jabaloyas JMM, et al. [SARSCoV-2 infection: implications for sexual andreproductive health. A position statementof the Asociación Española de Andrología,Medicina Sexual y Reproductiva (ASESA)].Revista internacional de andrologia. 2020;18(3):117–123. https://doi.org/10.1016/j.androl.2020.06.001.

  16. Sansone A, Jannini EA. COVID-19 and ErectileDysfunction: Endothelial Dysfunction andBeyond. The World Journal of Men’s Health.2021;39(4): 820. https://doi.org/10.5534/wjmh.210081.

  17. Mohamad NV, Wong SK, Wan Hasan WN,Jolly JJ, Nur-Farhana MF, Ima-Nirwana S,et al. The relationship between circulatingtestosterone and inflammatory cytokines inmen. The Aging Male: The Official Journal of theInternational Society for the Study of the AgingMale. 2019;22(2): 129–140. https://doi.org/10.1080/13685538.2018.1482487.

  18. Li N, Wang T, Han D. Structural, cellular andmolecular aspects of immune privilege in thetestis. Frontiers in Immunology. 2012;3. https://doi.org/10.3389/fimmu.2012.00152.

  19. Dutta S, Sengupta P. SARS-CoV-2 and MaleInfertility: Possible Multifaceted Pathology.Reproductive Sciences. 2021;28(1): 23–26.https://doi.org/10.1007/s43032-020-00261-z.

  20. Isidori AM, Giannetta E, Pofi R, Venneri MA,Gianfrilli D, Campolo F, et al. Targeting the NOcGMP-PDE5 pathway in COVID-19 infection.The DEDALO project. Andrology. 2021;9(1):33–38. https://doi.org/10.1111/andr.12837.

  21. Kharbach Y, Khallouk A. Male genital damage inCOVID-19 patients: Are available data relevant?Asian Journal of Urology. 2021;8(3): 324–326.https://doi.org/10.1016/j.ajur.2020.06.005.

  22. Yang M, Chen S, Huang B, Zhong JM, Su H,Chen YJ, et al. Pathological Findings in the Testesof COVID-19 Patients: Clinical Implications.European Urology Focus. 2020;6(5): 1124–1129.https://doi.org/10.1016/j.euf.2020.05.009.

  23. La Marca A, Busani S, Donno V, Guaraldi G,Ligabue G, Girardis M. Testicular pain as anunusual presentation of COVID-19: a brief reviewof SARS-CoV-2 and the testis. ReproductiveBiomedicine Online. 2020;41(5): 903–906.https://doi.org/10.1016/j.rbmo.2020.07.017.

  24. Abobaker A, Raba AA. Does COVID-19affect male fertility? World Journal of Urology.2021;39(3): 975–976. https://doi.org/10.1007/s00345-020-03208-w.

  25. Younis JS, Abassi Z, Skorecki K. Is there animpact of the COVID-19 pandemic on malefertility? The ACE2 connection. AmericanJournal of Physiology - Endocrinology andMetabolism. 2020;318(6): E878–E880. https://doi.org/10.1152/ajpendo.00183.2020.

  26. Rastrelli G, Di Stasi V, Inglese F, Beccaria M,Garuti M, Di Costanzo D, et al. Low testosteronelevels predict clinical adverse outcomes inSARS-CoV-2 pneumonia patients. Andrology.2021;9(1): 88–98. https://doi.org/10.1111/andr.12821.

  27. Whalen AM, Mateo CM, Growdon AS, MillerAF. Sacral Myeloradiculitis: An UncommonComplication of Genital Herpes Infection.Pediatrics. 2019;144(1): e20182631. https://doi.org/10.1542/peds.2018-2631.

  28. Paudel V. Erectile Dysfunction Secondary toHerpes Zoster. Journal of Nepal Health ResearchCouncil. 2020;17(4): 556–557. https://doi.org/10.33314/jnhrc.v17i4.2174.

  29. Rix G, Carroll D, MacFarlane J. Herpes Zosterproducing temporary erectile dysfunction.International Journal of Impotence Research.2001;13(6): 352–353. https://doi.org/10.1038/sj.ijir.3900786.

  30. Huang C -C., Chan W -L., Chen Y -C., ChenT -J., Chung C -M., Huang P -H., et al. Herpessimplex virus infection and erectile dysfunction:a nationwide population-based study. Andrology.2013;1(2): 240–244. https://doi.org/10.1111/j.2047-2927.2012.00037.x.

  31. Erol B, Avci A, Eken C, Ozgok Y. UrinaryRetention, Erectile Dysfunction and Meningitisdue to Sacral Herpes Zoster: A Case Reportand Review of the Literature. UrologiaInternationalis. 2009;82(2): 238–241. https://doi.org/10.1159/000200807.

  32. Ma BO. Association of erectile dysfunctionwith depression in patients with chronic viralhepatitis. World Journal of Gastroenterology.2015;21(18): 5641. https://doi.org/10.3748/wjg.v21.i18.5641.

  33. Kim M, Kim SY, Rou WS, Hwang SW, LeeBS. Erectile dysfunction in patients with liverdisease related to chronic hepatitis B. Clinicaland Molecular Hepatology. 2015;21(4): 352.https://doi.org/10.3350/cmh.2015.21.4.352.

  34. Hunter SS, Gadallah A, Azawi MK, Doss W.Erectile dysfunction in patients with chronichepatitis C virus infection. Arab Journal ofGastroenterology. 2014;15(1): 16–20. https://doi.org/10.1016/j.ajg.2014.01.012.

  35. De Oliveira CJV, Neto JAC, Andrade RCP,Rocha PN, De Carvalho Filho EM. Risk Factorsfor Erectile Dysfunction in Men with HTLV-1.The Journal of Sexual Medicine. 2017;14(10):1195–1200. https://doi.org/10.1016/j.jsxm.2017.08.001.

  36. Castro N, Oliveira P, Freitas D, Rodrigues W,Muniz A, Carvalho E. Erectile dysfunction andHTLV-I infection: a silent problem. InternationalJournal of Impotence Research. 2005;17(4): 364–369. https://doi.org/10.1038/sj.ijir.3901335.

  37. Bogdan AB, Silva RG, Fantin JP, Santos GG,Spessoto LC, Facio FN. Voiding and SexualDysfunction in a Young Patient After DengueFever. Journal of Endocrinology and Metabolism.2017;6(6): 187–189. https://doi.org/10.14740/jem380e.

  38. Hart TA, Mustanski B, Ryan DT, GorbachPM, Stall RD, Surkan PJ, et al. Depressionand Sexual Dysfunction Among HIV-Positiveand HIV-Negative Men Who Have Sex WithMen: Mediation by Use of Antidepressantsand Recreational Stimulants. Archives of SexualBehavior. 2015;44(2): 399–409. https://doi.org/10.1007/s10508-014-0279-1.

  39. De Ryck I, Van Laeken D, Nöstlinger C,Platteau T, Colebunders R, The EurosupportStudy Group. Sexual Satisfaction Among MenLiving with HIV in Europe. AIDS and Behavior.2012;16(1): 225–230. https://doi.org/10.1007/s10461-011-9987-x.

  40. Scanavino MDT. Sexual Dysfunctions ofHIV-Positive Men: Associated Factors,Pathophysiology Issues, and ClinicalManagement. Advances in Urology. 2011;2011:1–10. https://doi.org/10.1155/2011/854792.

  41. Asboe D, Catalan J, Mandalia S, DedesN, Florence E, Schrooten W, et al. Sexualdysfunction in HIV-positive men is multifactorial:A study of prevalence and associatedfactors. AIDS Care. 2007;19(8): 955–965.https://doi.org/10.1080/09540120701209847.

  42. Crum-Cianflone NF, Bavaro M, Hale B, AmlingC, Truett A, Brandt C, et al. Erectile Dysfunctionand Hypogonadism among Men with HIV.AIDS Patient Care and STDs. 2007;21(1): 9–19.https://doi.org/10.1089/apc.2006.0071.

  43. Juang SE, Ma KSK, Kao PE, Wei JCC, YipHT, Chou MC, et al. Human PapillomavirusInfection and the Risk of Erectile Dysfunction:A Nationwide Population-Based MatchedCohort Study. Journal of Personalized Medicine.2022;12(5): 699. https://doi.org/10.3390/jpm12050699.

  44. Ponholzer A, Temml C, Obermayr R,Wehrberger C, Madersbacher S. Is ErectileDysfunction an Indicator for Increased Risk ofCoronary Heart Disease and Stroke? EuropeanUrology. 2005;48(3): 512–518. https://doi.org/10.1016/j.eururo.2005.05.014.

  45. Winegar AL, Shepherd MD, Lawson KA,Richards KM. Comparison of the claim percentgross margin earned by Texas communityindependent pharmacies for dual-eligiblebeneficiary claims before and after MedicarePart D. Journal of the American PharmacistsAssociation. 2009;49(5): 617–622. https://doi.org/10.1331/japha.2009.08099.

  46. Rintala MAM, Greénman SE, Pöllänen PP,Suominen JJO, Syrjänen SM. Detection of highriskHPV DNA in semen and its association withthe quality of semen. International Journal ofSTD & AIDS. 2004;15(11): 740–743. https://doi.org/10.1258/0956462042395122.

  47. Kucukunal A, Altunay IK, Mercan S. SexualDysfunction in Men Suffering from GenitalWarts. The Journal of Sexual Medicine.2013;10(6): 1585–1591. https://doi.org/10.1111/jsm.12132.

  48. Yannas D, Frizza F, Vignozzi L, Corona G,Maggi M, Rastrelli G. Erectile DysfunctionIs a Hallmark of Cardiovascular Disease:Unavoidable Matter of Fact or Opportunityto Improve Men’s Health? Journal of ClinicalMedicine. 2021;10(10): 2221. https://doi.org/10.3390/jcm10102221.




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