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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2024, Number 1

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Rev Biomed 2024; 35 (1)

Genealogical analysis of type 2 Diabetes in extended multigenerational families of a Yucatecan community

Pinto-Escalante DC, Ruiz-García L, García-Escalante MG, Valadez-González N, Rubi-Castellanos R, Vera-Gamboa L, Pavía-Ruz N, González-Herrera L, Polanco-Reyes L, Valencia-Pacheco G, Nakazawa-Ueji YE

Language: Spanish
References: 47
Page: 1-9
PDF size: 300.00 Kb.


ABSTRACT

Introduction. Type 2 diabetes (T2D) affected 537 million of adults (20-79 years old in 2021, with an increasing trend, highlighting the younger age of onset. Family cases are frequent, they increase the risk of developing the pathology in healthy people in whom intervention is feasible to minimize risks. Genealogy is a tool to determine genetic susceptibility and other variables that contribute to determining the level of risk.
Aim. To analyze the behavior of T2D in extended multigenerational families from a community in Yucatán.
Material and methods. Conducted interviews were made to identify those affected with T2D in the community of Sisal, Yucatán. Genealogies were constructed and the number of affected individuals, their distribution by sex, parental branch of transmission, degree of kinship, and age of diagnosis were analyzed. Risk stratification of healthy people for developing T2D was made with ancestry information.
Results. Twenty four extended families were found, 769 individuals with a similar proportion of men/women, in 3-5 generations and 3-25 affected with T2D (32.4%). Women predominated in number of affected (61.3% deceased, 58% alive), high number with early onset age (‹45 years, 48.9%) and having affected parent (75%). Both parents affected represented 20.8%. Maternal descent prevailed (70.8%) among those affected. 71.6% of healthy people presented a high risk of developing T2D.
Conclusion. The genealogies made it possible to identify the predominance of women among the risk factors and the maternal branch among those affected, as well as high risk for T2DM among healthy people


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