medigraphic.com
ISSN 1659-1046 (Print)
Odovtos - International Journal of Dental Sciences

2023, Number 3

<< Back Next >>

Odovtos-Int J Dent Sc 2023; 25 (3)

Antimicrobial Efficacy of the Use of Mouthwash with Cetylpiridinium Chloride for Aerosol Producing Procedures. A Systematic Review

Arce-Toribio JP, Arbildo VHI, López-Flores AI

Language: English
References: 50
Page: 18-31
PDF size: 484.71 Kb.


ABSTRACT

The present research aims to determine the antimicrobial efficacy of the mouthwashes based on cetylpyridinium chloride (CPC), before aerosol producing dental procedures. A data search was performed during August 2021 in five databases MEDLINE (PubMed), SCOPUS, SCIELO, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar. Randomized clinical trials (RCTs) were included based on the PICO question, comparing the efficacy of the mouthwashes based on cetylpyridinium chloride (CPC), versus other mouthwashes and water, before aerosol producing dental procedures, papers in English, Spanish and Portuguese were included without time limits. The risk of the included studies was evaluated with the tool RoB 2.0. Number of registration PROSPERO N° CRD42021275982. 120 papers were obtained in the preliminary search, discarding those that didn’t comply with the selection criteria, leaving only 3 studies. These papers reported the use of cetylpyridinium chloride (CPC) was effective for the reduction of bacteria during the ultrasonic prophylactic procedure. The use of CPC mouthwashes previous to the dental treatment with ultrasonic prophylaxis showed only antibacterial capacity.


REFERENCES

  1. Watanabe E., Nascimento A.P., Guerreiro-Tanomaru J.M., Razaboni A.M., de Andrade D., Tanomaru-Filho M. Antiseptic mouthwashes: in vitro antibacterial activity. Acta Odontol Latinoam. 2015; 28 (2): 180-4. doi: 10.1590/S1852-48342015000200014

  2. Rösing C.K., Cavagni J., Gaio E.J., Muniz F.W.M.G., Ranzan N., Oballe H.J.R., et al. Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled randomized clinical trial. Braz Oral Res. 2017 Jul 3; 31: e47. doi: 10.1590/1807-3107BOR-2017.vol31.0047

  3. So Yeon L., Si Young L. Susceptibility of Oral Streptococci to Chlorhexidine and Cetylpyridinium Chloride. Biocontrol Sci. 2019; 24 (1):13-21. doi: 10.4265/bio.24.13

  4. Verma S.K., Dev Kumar B., Chaurasia A., Dubey D. Effectiveness of mouthwashagainst viruses: 2020 perspective. A systematic review. Minerva Dent Oral Sci. 2021 Oct; 70 (5): 206-213. doi: 10.23736/S2724-6329.21.04418-6

  5. Akbulut Y. The effects of different antiseptic mouthwash on microbiota around orthodontic mini-screw. Niger J Clin Pract. 2020 Nov; 23 (11): 1507-1513. doi: 10.4103/njcp.njcp_121_20

  6. Müller H.D., Eick S., Moritz A., Lussi A., Gruber R. Cytotoxicity and Antimicrobial Activity of Oral Rinses In Vitro. Biomed Res Int. 2017; 2017: 4019723. doi: 10.1155/2017/4019723

  7. American Dental Association. Oral health topics: mouthwash (mouthrinse); 2019. Available from https://www.ada.org/en/member-center/oral-health-topics/mouthrinse

  8. Brooks J.K., Bashirelahi N., Hsia R.C., Reynolds M.A. Charcoal-based mouthwashes: a literature review. Br Dent J. 2020 Feb; 228 (4): 290-294. doi: 10.1038/s41415-020-1265-8

  9. Takenaka S., Ohsumi T., Noiri Y. Evidence-based strategy for dental biofilms: Current evidence of mouthwashes on dental biofilm and gingivitis. Jpn Dent Sci Rev. 2019 Nov; 55 (1): 33-40. doi: 10.1016/j.jdsr.2018.07.001

  10. Marui V.C., Souto M.L.S., Rovai E.S., Romito G.A., Chambrone L., Pannuti C.M. Efficacy of preprocedural mouthrinses in the reduction of microorganisms in aerosol: A systematic review. J Am Dent Assoc. 2019 Dec; 150 (12): 1015-1026.e1. doi: 10.1016/j.adaj.2019.06.024

  11. Mao X., Auer D.L., Buchalla W., Hiller K.A., Maisch T., Hellwig E., et al. Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance. Antimicrob Agents Chemother. 2020 Jul 22; 64 (8): e00576-20. doi: 10.1128/AAC.00576-20

  12. Pitten F.A., Kramer A. Efficacy of cetylpyridinium chloride used as oropharyngeal antiseptic. Arzneimittelforschung. 2001; 51 (7): 588-95. doi: 10.1055/s-0031-1300084

  13. Van der Weijden F.A., Van der Sluijs E., Ciancio S.G., Slot D.E. Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control? Dent Clin North Am. 2015 Oct; 59 (4): 799-829. doi: 10.1016/j.cden.2015.06.002

  14. Baker N., Williams A.J., Tropsha A., Ekins S. Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19. Pharm Res. 2020 May 25; 37 (6): 104. doi: 10.1007/s11095-020-02842-8

  15. Moran J.M. Home-use oral hygiene products: mouthrinses. Periodontol 2000. 2008; 48: 42-53. doi: 10.1111/j.1600-0757.2008.00260.x

  16. Herrera D., Santos S., Ferrús J., Barbieri G., Trombelli L., Sanz M. Efficacy of a 0.15% benzydamine hydrochloride and 0.05% cetylpyridinium chloride mouth rinse on 4-day de novo plaque formation. J Clin Periodontol. 2005 Jun; 32 (6): 595-603. doi: 10.1111/j.1600-051X.2005.00718.x

  17. Miranda S.L.F., Damaceno J.T., Faveri M., Figueiredo L.C., Soares G.M.S., Feres M., et al. In Vitro Antimicrobial Effect of Cetylpyridinium Chloride on Complex Multispecies Subgingival Biofilm. Braz Dent J. 2020 Mar-Apr; 31 (2): 103-108. doi: 10.1590/0103-6440202002630

  18. Gunsolley J.C. Clinical efficacy of antimicrobial mouthrinses. J Dent. 2010 Jun; 38 Suppl 1: S6-10. doi: 10.1016/S0300-5712(10)70004-X

  19. Ouhayoun J.P. Penetrating the plaque biofilm: impact of essential oil mouthwash. J Clin Periodontol. 2003; 30 Suppl 5: 10-2. doi: 10.1034/j.1600-051x.30.s5.4.x

  20. García V., Rioboo M., Serrano J., O'Connor A., Herrera D., Sanz M. Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloridemouth-rinse in a 4-day non-brushing model. Int J Dent Hyg. 2011 Nov; 9 (4): 266-73. doi: 10.1111/j.1601-5037.2010.00490.x

  21. Haps S., Slot D.E., Berchier C.E., Van der Weijden G.A. The effect of cetylpyridinium chloride-containing mouth rinses as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review. Int J Dent Hyg. 2008 Nov; 6 (4): 290-303. doi: 10.1111/j.1601-5037.2008.00344.x

  22. Van Leeuwen M.P., Rosema N.A., Versteeg P.A., Slot D.E., Van Winkelhoff A.J., Van der Weijden G.A. Long-term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6-month randomized, vehicle-controlled clinical trial. Int J Dent Hyg. 2015 May; 13 (2): 93-103. doi: 10.1111/idh.12082

  23. Mukherjee P.K., Esper F., Buchheit K., Arters K., Adkins I., Ghannoum M.A., et al. Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections. BMC Infect Dis. 2017 Jan 14; 17 (1): 74. doi: 10.1186/s12879-016-2177-8

  24. Carrouel F., Gonçalves L.S., Conte M.P., Campus G., Fisher J., Fraticelli L., et al. Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2. J Dent Res. 2021 Feb; 100 (2): 124-132. doi: 10.1177/0022034520967933

  25. Seo H.W., Seo J.P., Kim Y.J., Jung G. WITHDRAWN: Cetylpyridinium chloride as a novel inhibitor of hepatitis B viral capsid assembly. Biochem Biophys Res Commun. 2018 Jan 17: S0006-291X (18) 30103-7. doi: 10.1016/j.bbrc.2018.01.088

  26. Alvarez D.M., Duarte L.F., Corrales N., Smith P.C., González P.A. Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts. Antiviral Res. 2020 Jul;179:104818. doi: 10.1016/j.antiviral.2020.104818

  27. Harrel S.K., Molinari J. Aerosols and splatter in dentistry: a brief review of the literature and infection control implications. J Am Dent Assoc. 2004 Apr; 135 (4): 429-37. doi: 10.14219/jada.archive.2004.0207

  28. Innes N., Johnson I.G., Al-Yaseen W., Harris R., Jones R., Kc S., McGregor S., et al.A systematic review of droplet and aerosol generation in dentistry. J Dent. 2021 Feb;105:103556. doi: 10.1016/j.jdent.2020.103556

  29. Ge Z.Y., Yang L.M., Xia J.J., Fu X.H., Zhang Y.Z. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020 May; 21 (5): 361-368. doi: 10.1631/jzus.B2010010

  30. Zemouri C., Volgenant C.M.C., Buijs M.J., Crielaard W., Rosema N.A.M., Brandt B.W., et al. Dental aerosols: microbial composition and spatial distribution. J Oral Microbiol. 2020 May 13; 12 (1): 1762040. doi: 10.1080/20002297.2020.1762040

  31. Hubar J.S., Pelon W. Low-cost screening for microbial contaminants in aerosols generated in a dental office. Gen Dent. 2005 Jul-Aug; 53 (4): 270-2. PMID: 16158795.

  32. Joshi A.A., Padhye A.M., Gupta H.S. Efficacy of Two Pre-Procedural Rinses at Two Different Temperatures in Reducing Aerosol Contamination Produced During Ultrasonic Scaling in a Dental Set-up - A Microbiological Study. J Int Acad Periodontol. 2017 Oct 1; 19 (4): 138-144. PMID: 31473729.

  33. Matys J., Grzech-Leśniak K. Dental Aerosol as a Hazard Risk for Dental Workers. Materials (Basel). 2020 Nov 12; 13 (22): 5109. doi: 10.3390/ma13225109

  34. Herrera D., Escudero N., Pérez L., Otheo M., Cañete-Sánchez E., Pérez T., et al. Clinical and microbiological effects of theuse of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial. Eur J Orthod. 2018 Sep 28; 40 (5): 465-474. doi: 10.1093/ejo/cjx096

  35. Haraszthy V.I., Sreenivasan P.K. Microbiological and clinical effects of an oral hygiene regimen. Contemp Clin Trials Commun. 2017 Aug 18; 8: 85-89. doi: 10.1016/j.conctc.2017.08.010

  36. Feres M., Figueiredo L.C., Faveri M., Stewart B., de Vizio W. The effectiveness of a preprocedural mouthrinse containing cetylpyridinium chloride in reducing bacteria in the dental office. J Am Dent Assoc. 2010 Apr; 141 (4): 415-22. doi: 10.14219/jada.archive.2010.0193

  37. Retamal-Valdes B., Soares G.M., Stewart B., Figueiredo L.C., Faveri M., Miller S., et al. Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial. Braz Oral Res. 2017 Mar 30; 31: e21. doi: 10.1590/1807-3107BOR-2017.vol31.0021

  38. Seneviratne C.J., Balan P., Ko K.K.K., Udawatte N.S., Lai D., Ng D.H.L., et al. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection. 2021 Apr; 49 (2): 305-311. doi: 10.1007/s15010-020-01563-9

  39. Mateos-Moreno M.V., Mira A., Ausina-Márquez V., Ferrer M.D. Oral antiseptics against coronavirus: in-vitro and clinical evidence. J Hosp Infect. 2021 Jul; 113: 30-43. doi: 10.1016/j.jhin.2021.04.004

  40. Moosavi M.S., Aminishakib P., Ansari M. Antiviral mouthwashes: possible benefit for COVID-19 with evidence-based approach. J Oral Microbiol. 2020 Jul 17; 12 (1): 1794363. doi: 10.1080/20002297.2020.1794363

  41. Cavalcante-Leão B.L., de Araujo C.M., Basso I.B., Schroder A.G., Guariza-Filho O., Ravazzi G.C., et al. Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19? A systematic review. J Clin Exp Dent. 2021 Feb 1; 13 (2): e179-e189. doi: 10.4317/jced.57406

  42. Amato A., Caggiano M., Amato M., Moccia G., Capunzo M., De Caro F. Infection Control in Dental Practice During the COVID-19 Pandemic. Int J Environ Res Public Health. 2020 Jul 2; 17 (13): 4769. doi: 10.3390/ijerph17134769

  43. Popkin D.L., Zilka S., Dimaano M., Fujioka H., Rackley C., Salata R., et al. Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo. Pathog Immun. 2017; 2 (2): 252-269. doi: 10.20411/pai.v2i2.200

  44. Vergara-Buenaventura A., Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. Br J Oral Maxillofac Surg. 2020 Oct; 58 (8): 924-927. doi: 10.1016/j.bjoms.2020.08.016

  45. Bentley C.D., Burkhart N.W., Crawford J.J. Evaluating spatter and aerosol contamination during dental procedures. J Am Dent Assoc. 1994 May; 125 (5): 579-84. doi: 10.14219/jada.archive.1994.0093

  46. Grenier D. Quantitative analysis of bacterial aerosols in two different dental clinic environments. Appl Environ Microbiol. 1995 Aug; 61 (8): 3165-8. doi: 10.1128/aem.61.8.3165-3168.1995

  47. Rivera-Hidalgo F., Barnes J.B., Harrel S.K. Aerosol and splatter production by focused spray and standard ultrasonic inserts. J Periodontol. 1999 May; 70 (5): 473-7. doi: 10.1902/jop.1999.70.5.473

  48. Reddy S., Prasad M.G., Kaul S., Satish K., Kakarala S., Bhowmik N. Efficacy of 0.2% tempered chlorhexidine as a pre-procedural mouth rinse: A clinical study. J Indian Soc Periodontol. 2012 Apr; 16 (2): 213-7. doi: 10.4103/0972-124X.99264. PMID: 23055587; PMCID: PMC3459501

  49. Calle R., Sánchez D.B.B.Y.A.G. Actualización de las infecciones respiratorias en Urgencias [Update on respiratory infections in the emergency department]. Medicine (Madr). 2019 Oct; 12 (88): 5170-5179. Spanish. doi: 10.1016/j.med.2019.10.013. Epub 2019 Nov 7. PMID: 32287912; PMCID: PMC7143591.

  50. Han Y.W. Fusobacterium nucleatum: a commensal-turned pathogen. Curr Opin Microbiol. 2015 Feb; 23: 141-7. doi: 10.1016/j.mib.2014.11.013. Epub 2015 Jan 8. PMID: 25576662; PMCID: PMC4323942.




2020     |     www.medigraphic.com