medigraphic.com
ISSN 1561-2988 (Print)

2021, Number 4

<< Back Next >>

Rev Cubana Farm 2021; 54 (4)

Antifungal and cytotoxicity effect of floral extracts of Fridericia platyphylla and Fridericia florida

Pereira MFAC, Abadia VMV, Fernandes Batista-Ventura HR, Alves PC, de Souza CCF

Language: English
References: 37
Page: 1-13
PDF size: 429.91 Kb.


ABSTRACT

Introduction: Fridericia platyphylla and Fridericia florida are two species belonging to the Bignoniaceae family with potential biological activities such as antifungal and cytotoxic.
Objective: To evaluate the floral extracts of Fridericia platyphylla and Fridericia florida for antifungal activity on Candida sp. and cytotoxic activity on Artemia salina.
Methods: F. platyphylla and F. florida flowers, were collected and, the extract produced by static maceration using hydroethanolic solution (70%). The antifungal activity on Candida sp. was carried out using paper disk diffusion methodology, and the cytotoxic activity on Artemia salina, both assay in different concentrations of extract.
Results: The floral extract of F. platyphylla showed potential inhibitory activity on C. guilliermondii 13.8-9.7 mm and C. albicans 18.6-14.5 mm at the highest concentrations of 100-50 mg mL-1, respectively. For the floral extract of F. florida it showed potential inhibitory action on C. albicans 11.5-6.8 mm and C. krusei 14.3-11.1 mm at the highest concentrations between 100 and 50 mg mL- 1, respectively. The extracts proved to be toxic with LC50 of 237.81 and 301.20 μg mL-1, respectively.
Conclusions: The floral extracts of Fridericia platyphylla and Fridericia florida demonstrated in this study, the first results of antifungal activity on Candida and cytotoxic action on Artemia salina. In view of these results, it is observed that the extracts of Fridericia species evaluated have potential for the development of new phytotherapic drugs.


REFERENCES

  1. Lohmann LG. Untangling the phylogeny of neotropical lianas (Bignonieae,Bignoniaceae). Amer J Bot. 2006 [cited 2021/03/21];93:304-318. DOI:10.3732/ajb.93.2.304

  2. Mourão PJP, Macedo JAB, Silva APAB, Silva CN, Marques DD, Cunha RM.Pharmacological analysis of two ethanolic extracts from species of Fridericiagenus. Rev Uni Vale Rio Verde. 2017 [cited 2021/03/10];15(2):122-31. DOI:10.5892/ruvrd.v15i2.3291.g3218

  3. Menezes Filho ACP. Avaliação química, antifúngica e antioxidante do óleoessencial da flor de Fridericia platyphylla (Cham.) L.G. Lohmann. ScientiaNaturalis. 2020 [cited 2021/03/10];2(1):42-58. DOI:https://revistas.ufac.br/index.php/SciNat/article/view/3285

  4. Paula SM, Boselli MA, Sanches MC. Chlorophyll fluorescence and initialgrowth of two liana species, Cuspidaria sceptrum (Cham.) L.G. Lohmann andFridericia florida (DC) L.G. Lohmann, under changes of natural light conditions.Photosynthetica. 2019 [cited 2021/03/11];57(1):170-180. DOI:10.32615/ps.2019.004

  5. Alcerito T, Barbo FE, Negri G, Santos DY, Meda CI, Young MC, Chavez D,Blatt CT. Foliar epicuticular wax of Arrabidaea brachypoda: flavonoids andantifungal activity. Biochem Systemat Ecol. 2002 [cited 2021/03/11];30(7):677-683. DOI: https://doi.org/10.1016/S0305-1978(01)00149-1

  6. Duarte DV, Romero R. Bignoniaceae na reserva do clube caça e pescaItororó, Uberlândia, MG, Brasil. Hoehnea. 2020 [cited 2021/03/11];47:1-23.DOI: 10.1590/2236-8906-106/2019

  7. Serpeloni JM, Specian AFL, Ribeiro DL, Benício LM, Nunes HL, Franchi LP,Rocha CQ, Vilegas W, Varanda EA, Cólus IMS. Fridericia platyphylla (Cham.)L.G. Lohmann root extract exerts cytotoxic and antiproliferative effects ongastric tumor cells and downregulates BCL-XL, BIRC5, and MET genes. Humanand Experimental Toxicology. 2020 [cited 2021/03/16];39(3):338-54. DOI:10.1177/0960327119888261

  8. Rocha CQ, Vilela FC, Cavalcante GP. Anti-inflammatory and antinociceptiveeffects of Arrabidaea brachypoda (DC.) bureau roots. J Ethnopharmacol. 2011[cited 2021/03/16];133(2):396-401. DOI: 10.1016/j.jep.2010.10.009

  9. Kaehler M. Fridericia resinosa: a new species of Bignoniaceae from Brazil.Phytotaxa. 2020 [cited 2021/03/26];461(2). DOI: 10.11646/phytotaxa.461.2.5

  10. Rocha CQ, Faria FM, Marcourt L. Gastroprotective effects of hydroethanolicroot extract of Arrabidaea brachypoda: evidences of cytoprotection and isolation of unusual glycosylated polyphenols. Phytochem. 2017 [cited2021/03/25];135:93-105. DOI: 10.1016/j.phytochem.2016.12.002

  11. Rocha CQ, Queiroz EF, Meira CS, Dimeric flavonoids from Arrabidaeabrachypoda and assessment of their anti-Trypanosoma cruzi activity. J NatProd. 2014 [cited 2021/03/25];77:1345-50. DOI: 10.1021/np401060j

  12. Milani RR, Alves OJA, Bertanha CS, Gimenez VMM. Antipromastigote andcytotoxic activities of flavonoids from Fridericia speciosa leaves. Quím Nova.2020 [cited 2021/03/25];43(10):1404-07. DOI: 10.21577/0100-4042.20170628

  13. Inoue MH, Palermo GPS, Dallacort KFM, Conciani PA, Bem R, Cavalcante NR.Levantamento das ervas daninhas nas épocas secas e chuvosas em áreas depastagens plantadas no sudoeste do Mato Grosso. Rev Ciên Agro-Ambientais.2012 [cited 2021/02/23];10(1):81-92.

  14. Takenaka IKTM, Amorim JM, Barros PAV, Brandão GC, Contarini SM.Chemical characterization and anti-inflammatory assessment of thehydroethanolic extract of Fridericia chica. Rev Bras Farmacog. 2020 [cited2021/03/17];30:559-567. DOI: 10.1007/s43450-020-00085-7

  15. Tuffi SLD, Cardoso FO, Santos AJ, Santos BFS, Felix RC, Leite FP. Floristicand structural variation of weeds in Eucalyptus plantations as influenced byrelief and time of year. Plant Daninha. 2013 [cited 2021/01/14];31(3):491-499.DOI: 10.1590/S0100-83582013000300001

  16. Mesquita ML, Paula JE, Pessoa C, Moraes MO, Costa-Lotufo LV, Grougnet R,Michel S, Tillequin F, Espindola LS. Cytotoxic activity of Brazilian Cerradoplants used in traditional medicine against cancer cell lines. J Ethnopharmacol.2009 [cited 2021/03/22];123(3):439-45. DOI: 10.1016/j.jep.2009.03.018

  17. Castillo BD, Jiménez YM, Nieves MF, Peláez J. Composición química deaceites esenciales de hojas de Fridericia florida DC. y Fridericia chica (Bonpl.).Rev Facult Cien Básicas. 2019 [cited 2021/03/22];15(1):63-70. DOI:10.18359/rfcb.3676

  18. Paula SM, Sanches MC. Atividade da fluorescência da clorofila a em duasespécies de lianas de florestas semidecíduas. [cited 2021/03/22]. In: 64ºCongresso Nacional de Botânica, Belo Horizonte, 10-15 Novembro, 2013.

  19. Castro TL, Coutinho HDM, Gedeon CC, Santos JM, Santana WJ, Souza LBS.Mecanismos de resistência da Candida sp WWA antifúngicos. Infarma. 2006[cited 2021/03/19];18(9/10):30-35.

  20. Vieira AJH, Santos JI. Mecanismos de resistência de Candida albicans aosantifúngicos anfotericina B, fluconazol e caspofungina. RBAC. 2017 [cited2021/03/06];49(3):235-39. Disponible en:http://www.rbac.org.br/artigos/mecanismos-de-resistencia-de-candidaalbicans-aos-antifungicos-anfotericina-b-fluconazol-e-caspofungina/

  21. Venturoso LR, Bacchi LMA, Gavassoni WL, Conus LA, Pontim BCA, BergaminAC. Atividade antifúngica de extratos vegetais sobre o desenvolvimento defitopatógenos. Summa Phytopathol. 2011 [cited 2021/01/15];37(1):18-23. DOI:10.1590/S0100-54052011000100003

  22. Ogbole OO, Segun PA, Adeniji AJ. In vitro cytotoxic activity of medicinalplants from Nigeria ethnomedicine on rhabdomyosarcoma cancer cell line andHPLC analysis of active extracts. BMC Complementary and AlternativeMedicine. 2017 [cited 2021/03/10];17:494. DOI: 10.1186/s12906-017-2005-8

  23. Brandão GC, Kroon EG, Filho JDS, Oliveira AB. Antiviral activity ofFridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts andconstituents. J Trop Med. 2017 [cited 2021/03/10];2017:1-11. DOI:10.1155/2017/6106959

  24. Menezes Filho ACP, Oliveira Filho JG, Cruz RM, Silva AP, Sousa WC, CastroCFS. Evaluacion química, fisicoquímica y actividad antifúngica de los aceitesesenciales de Bauhinia variegata L. (Fabaceae). Rev Cub Farmacia. 2020 [cited2021/03/19];53(3):e434. DOI: Available from:http://www.revfarmacia.sld.cu/index.php/far/article/view/434

  25. Lima JCS, Oliveira RG, Silva VC, Sousa Jr PT, Violante IMP. Antiinflammatoryactivity of a4’,6’,7-trihydroxy-5-methoxyflavone from Fridericiachica (Bonpl.) L.G. Lohmann. Nat Prod Res. 2020 [cited 2021/03/19];34(5):726-30. DOI: https://doi.org/10.1080/14786419.2018.1495636

  26. Pereira R, Neto FÂM, Aguiar FLL, Souza EB, Santos HS, Cavalcante CSP,Fontenelle ROS. Atividade antifúngica, sinergismo e citotoxicidade do extratoetanólico da casca de Myroxylon peruiferum L. f. Unicor. 2018;16(1):1-9. DOI:10.5892/ruvrd.v16i1.3751

  27. Souza CM, Gasparino EC. Pollen morphology of Fridericia Mart.(Bignoniaceae) from Brazilian forest fragments. Braz J Bot. 2014 [cited2021/03/12];37(1):83-94. DOI: 10.1007/s40415-013-0042-1

  28. Fisher E, Theisen I, Lohmann LG. Bignoniaceae. pp. 9-38 in: Kadereit W.(ed.), The families and genera of vascular plants, vol. 7. Heidelberg: Springer.[cited 2021/03/10DOI: 10.1007/978-3-642-18617-2_2

  29. Lohmann LG, Taylor CM. A new generic classification of tribe Bignonieae(Bignoniaceae). Ann Missouri Bot Gard. 2014 [cited 2021/02/14];99:348-489.DOI: 10.3417/2003187

  30. Kaehler M, Michelangeli FA, Lohmann LG. Fine tuning the circumscription ofFridericia (Bignonieae, Bignoniaceae). Taxon. 2019 [cited2021/01/09];68(4):751-70. DOI: 10.1002/tax.12121

  31. Vasconcelos TNC, Silva JS, Ianhez ML, Proença CEB. Floristic survey of theBrazilian ages memorial: a Cerrado sensu stricto area with na educationalrelevance – Check List. 2015 [cited 2021/02/18];11(4):1-9. DOI:10.15560/11.4.1689

  32. Rahman MA, Sultana R, Emran TB, Islam MS, Rahman MA, Chakma JS, et al.Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysisand cytotoxicity. BMC. 2013 [cited 2021/01/20];13:25. DOI: 10.1186/1472-6882-13-25

  33. Meyer BN, Ferrigni NR, Putnan JE, Jacobsen LB, Nichols DE, McAughlin JL.Brine shrimp: A convenient general bioassay for active plant constituents.Planta Med. 1982 [cited 2021/03/23];45(5):31-4. DOI: 10.1055/s-2007-971236

  34. Otsuki N, Dang NH, Kumagai E, Kondo A, Iwata S, Morimoto C. Aqueousextract of Carica papaya leaves exhibit anti-tumor activity andimmunomodulatory effects. J Ethnopharmacol. 2010 [cited2021/02/11];127(3):760-67. DOI: 10.1016/j.jep.2009.11.024

  35. Carvalho FMA, Schneider JK, Jesus CVF et al. Brazilian red propolis:extracts production, physicochemical characterization, and cytotoxicity profilefor antitumor activity. Biomolecules. 2020 [cited 2021/02/11];10(5):726. DOI:10.3390/biom10050726

  36. Nunes HL, Tuttis K, Serpenoli JM, Nascimento JR, Rocha CQ, Silva VAO,Lengert AVH, Reis RM, Cólus IMS. Characterization of the in vitro cytotoxiceffects of brachydins isolated from Fridericia platyphylla in a prostate cancercell line. J Toxicol Environ Heal. 2020 [cited 2021/01/25];83(15-16):1-12. DOI:10.1080/15287394.2020.1784339

  37. Serpenoli JM, Specian AFL, Ribeiro DL, Benício LM, Nunes HL, Franchi LP, etal. Fridericia platyphylla (Cham.) L.G. Lohmann root extract exerts cytotoxicand antiproliferative effects on gastric tumor cells and downregulates BCL-XL,BIRC5, and MET genes. Human Exp Toxicol. 2019 [cited 2021/02/26];39(3):338-54. DOI: 10.1177%2F0960327119888261




2020     |     www.medigraphic.com