2022, Number 1
<< Back
Rev Cubana Estomatol 2022; 59 (1)
Kaposi sarcoma in late HIV/AIDS diagnosis
Camacho OCG, Lagunes LMA, Jimenez SJD, Padovani CS
Language: Spanish
References: 21
Page:
PDF size: 696.30 Kb.
ABSTRACT
Introduction:
Kaposi sarcoma is a multifocal malignant neoplasm of endothelial cells which presents with characteristic lesions on the skin, mouth and lymph glands.
Objective:
Describe a case of Kaposi sarcoma with characteristics that hindered HIV infection diagnosis.
Case presentation:
A case is presented of a male 30-year-old patient recently diagnosed with acquired immunodeficiency syndrome, and not following any treatment. The patient was referred to the maxillofacial surgery service for right cervical adenopathy biopsy. Physical examination revealed generalized edema in both lower limbs, with hyperpigmented lesions of macular and papular appearance and various shades of color. A purplish pigmented lesion was detected in the hard palate mucosa. The lesion covered the palatal midline and extended toward the left hemiarch. Exeresis of the adenopathy was performed for diagnostic purposes, confirming the diagnosis of Kaposi sarcoma.
Conclusions:
Lack of familiarity with the clinical characteristics of Kaposi sarcoma, and not performing a biopsy of the skin lesions and a complete examination of the oral cavity, made the neoplasm go unnoticed to routine medical tests, leading to low suspicion of HIV/AIDS infection and delaying timely treatment. In advanced immunosuppression, Kaposi sarcoma related to acquired immunodeficiency syndrome tends to be more aggressive.
REFERENCES
México. Secretaría de Salud, Centro Nacional para la Prevención y el Control del VIH y el sida, Dirección General de Epidemiología. Vigilancia epidemiológica de casos de VIH/sida en México. Registro Nacional de Casos de sida. Actualización al 3er. trimestre del 2019. 2019. [acceso 05/02/2020]. Disponible en: Disponible en: https://www.gob.mx/cms/uploads/attachment/file/513719/RN_3erTrim_2019.pdf
Hwang JP, Granwehr BP, Torres HA, Suarez-Almazor ME, Giordano TP, Barbo AG, et al. HIV testing in patients with cancer at the initiation of therapy at a large US comprehensive cancer center. J Oncol Pract. 2015;11:384-90. PMID: 26243649
Li J, Thompson TD, Tai E, Zhao G, Oster AM. Testing for human immunodeficiency virus among cancer survivors under age 65 in the United States. Prev Chronic Dis.. 2014 [acceso 05/02/2020];11:E200. PMID: https://pubmed.ncbi.nlm.nih.gov/25393748/
Yarchoan R, Uldrick TS. HIV-Associated Cancers and Related Diseases. N Engl J Med. 2018 [acceso 05/02/2020]; 378 (11):1029-1041. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890231/
Robbins HA, Shiels MS, Pfeiffer RM, Engels EA. Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States. AIDS. 2014;28(6):881-90. PMID: 24300545
México. Gobierno de México, Secretaría de Salud, Centro Nacional para la Prevención y el Control del VIH y el sida. Día mundial del sida. 2019. [acceso 20/02/2020]. Disponible en: Disponible en: https://www.gob.mx/cms/uploads/attachment/file/513718/BOLETIN_D_A_MUNDIAL_28_NOV_VFIN.pdf
Cornejo P, Cavildo D, Volkow P. Non-AIDS defining cancer (NADC) among HIV-infected patients at an oncology tertiary-care center in Mexico. AIDS Res Ther. 2018;15(1):16. PMID: 30368240
Cañas-Ruano E, Martín-Castillo M, Raventós B, Burgos J, Curran A, Navarro J, et al. Incidence of malignancy in a Spanish cohort of patients infected by the human immunodeficiency virus. Med Clin (Barc). 2020;155(7):288-94. PMID: 32005558
Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of Herpesvirus-Like DNA Sequences in AIDS-associated Kaposi's Sarcoma. Science. 1994;1266:1865-9. PMID: 7997879
Florek A, Eilers D, Armstrong A. A case of Kaposi sarcoma in an immunocompetent, heterosexual Irish man: a discussion of etiology and viral transmission. Dermatol Online J. 2015;21(10). PMID: 26632797
Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med. 2000;342(14):1027-38. PMID: 10749966
Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D. Kaposi sarcoma. Nat Rev Dis Primers. 2019;62(6):730-8. PMCID: PMC6685213
Forrestel A, Naujokas A, Martin J, Maurer T, McCalmont T, Laker-Opwonya M, et al. Bacillary angiomatosis masquerading as Kaposi's sarcoma in East Africa. J Int Assoc Provid AIDS Care. 2015;14(1):21-5. PMID: 24718378
Giudice G, Paciel D, Vola M, Agorio C. Co-infección Sarcoma de Kaposi - Histoplasmosis en una paciente con VIH. 16.º Congreso Uruguayo de Dermatología 16-20 Oct 2018. Montevideo; 2019. [acceso 09/02/2020]. Disponible en: Disponible en: http://www.infectologia.edu.uy/produccion-cientifica/congresos/2018/co-infeccion-sarcoma-de-kaposi-histoplasmosis-en-una-paciente-con-vih
Katano H. Pathological Features of Kaposi's Sarcoma-Associated Herpesvirus Infection. Adv Exp Med Biol. 2018;1045:357-76. PMID: 29896675
Cacciari V, Arra A, D’Alessandro D, Errea S, Kohan D, Elsner B, et al. Enfermedad de Castleman e infección por HIV. Presentación de dos casos y revisión de la literatura. Acta SIDA Infec. 2015 [acceso 09/02/2020]; 23(88):33-41. Disponible en: Disponible en: https://infectologia.info/wp-content/uploads/2016/07/ASEI-88-2.pdf
Rodríguez L, Mahaht G, Salazar L, Magola R. Sarcoma de Kaposi y enfermedad de Castleman multicéntrica VHH-8 positivo - VIH Negativo. Acta Med Colomb. 2018;43(1):30-2. DOI: https://doi.org/10.36104/amc.2018.1357
Krown S, Testa M, Huang J. AIDS-related Kaposi's Sarcoma: Prospective Validation of the AIDS Clinical Trials Group Staging Classification. AIDS Clinical Trials Group Oncology Committee. J Clin Oncol. 1997;15:3085-92. PMID: 9294471
Maya A, Segovia S, Madrigal S, Abrego I, Salas J. Sarcoma de Kaposi en región oral y maxilofacial, una neoplasia olvidada. Rev Esp Cir Oral Maxilofac. 2018 [acceso 10/02/2020]; 40(1):22-6. Disponible en: Disponible en: https://www.sciencedirect.com/science/article/pii/S1130055817300060?via%3Dihub
Volkow P, Cesarman G, Garciadiego P, Rojas E, Cornejo P. Clinical characteristics, predictors of immune reconstitution inflammatory syndrome and long-term prognosis in patients with Kaposi sarcoma. AIDS Res Ther. 2017;14(1):30. PMID: 28558783
Berretta M, Martellotta F, Di Francia R, Spina M, Vaccher E, Balestreri L. Clinical presentation and outcome of non-AIDS defining cancers, in HIV-infected patients in the ART-era: The Italian Cooperative Group on AIDS and tumors activity. Eur Rev Med Pharmacol Sci. 2015;19(19):3619-34. PMID: 26502852