2023, Number 2
Lymphoblastic leukemia secondary to lymphoblastic lymphoma with development of bone marrow aplasia post-induction of Hyper-CVAD
Language: Spanish
References: 10
Page: 106-111
PDF size: 289.01 Kb.
ABSTRACT
Background: Secondary leukemias are broadly defined as a group of cancers that arise after the existence of a previous malignant neoplasm or in patients previously treated with cytotoxic therapy, that is, chemotherapy or radiotherapy.Clinical case: A 32-year-old male patient with lymphoblastic lymphoma who received 8 cycles of chemotherapy with subsequent development of secondary acute lymphoblastic leukemia, requiring initiation of a remission induction chemotherapy scheme based on Hyper-CVAD, developing secondary bone marrow aplasia.
Conclusions: Secondary lymphoblastic leukemias are a poorly characterized condition due to limited literature and the absence of therapeutic protocols.
REFERENCES
Aldoss I, Stiller T, Tsai NC, Song JY, Cao T, Bandara NA,Salhotra A, Khaled S, Aribi A, Al Malki MM, Mei M, Ali H,Spielberger R, O'Donnell M, Snyder D, Slavin T, NakamuraR, Stein AS, Forman SJ, Marcucci G, Pullarkat V. Therapyrelatedacute lymphoblastic leukemia has distinct clinicaland cytogenetic features compared to de novo acutelymphoblastic leukemia, but outcomes are comparablein transplanted patients. Haematologica 2018; 103 (10):1662-1668. doi: 10.3324/haematol.2018.193599.
Pagano L, Pulsoni A, Tosti ME, Annino L, et al. Acutelymphoblastic leukaemia occurring as second malignancy:report of the GIMEMA Archive of Adult AcuteLeukaemia. Gruppo Italiano Malattie Ematologiche Malignedell'Adulto. Br J Haematol 2001; 106 (4): 1037-1040.https://doi.org/10.1046/j.1365-2141.1999.01636.x