2004, Number S2
<< Back Next >>
Gac Med Mex 2004; 140 (S2)
Fisiopatology of the obesity
Hernández-Jiménez S
Language: Spanish
References: 30
Page: 27-32
PDF size: 521.35 Kb.
ABSTRACT
Obesity is a multi-cause syndrome. Overfeeding and low
exercise produces excess of body fat. There are individual
and population differences in energy balance, (ethnical,
diet behavior, longer life expectancies). Genetic factors
may influence the setting of obesity, but the calorie intake,
physical activity, and lifestyle are critical determinants. As
a consequence of the complex mechanisms involved in the
pathogenesis of this syndrome and its complications, each
model used in the diagnostic and therapeutic approach are
partial. New evidences on the genetic and neuroendocrine
factors in obesity are emerging, however, a holistic model
is needed to understand this syndrome where biologic,
psychological and social factors act together in a very
intricate way. Using this model, better understanding in
prevention and treatment is expected.
REFERENCES
Bouchard C, Desprès JP, Mauriege P. Genetic and nongenetic determinants of regional fat distribution. Endocr Rev 1993;14:72-93.
Groop L, Orho-Melander M. The dysmetabolic syndrome. J Intern Med 2001;205:105-20.
Sims EAH. Are there persons who are obese, but metabolically healthy? Metabolism 2001;50:1499-1504.
Pérusse L, Chagnon YC, Weisnagel J, et al. The human obesity gene map: the 2000 update. Obes Res 2001;9:135-169.
Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332:621-8.
Campfield LA, Brandon P, Smith FJ. On-line continuous measurement of blood glucose and meal pattern in free-feeding rats: the role of glucose in meal initiation. Brain Res Bull 1985;14:605-16.
Rosenbaum M, Nicholson M, Hirsch J, et al. Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab 1997;82(11):3647-54.
Banks WA, Coon AB, Moinuddin A, Schultz JM, Nakaoke R, Morley J. Triglycerides induce leptin resistance at the bloodbrain barrier. Diabetes 2004;53:1253-60.
Cohen B, Novick D, Rubinstein M. Modulation of insulin activity by leptin. Science 1996;274:1185-8.
Crespo J, Rivero M, Fabrega E. Plasma leptin and TNF-alpha levels in chronic hepatitis C patients and their relationship to hepatic fibrosis. Dig Dis Sci 2002;47:604-10.
Leclercq IA, Farrell GC, Schriemer R, Robertson GR. Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 2002;37:206-13.
Campfield LA. Neurobiology of OB protein (leptin). Horm Res 2000;26:1-11.
Sheehan MT, Jensen MD. Metabolic complications of obesity. Pathophysiologic considerations. Med Clin North Am 2000;84:363-85.
Goossens GH, Blaak EE, Van Baak MA. Possible involvement of the adipose tissue renin-angiotensin system in the pathophysiology of obesity and obesity-related disorders. Obes Rev 2003;4:43-55.
Bullo-Bonet M, García-Lorda P, López-Soriano FJ, Argiles JM, Salas-Salvado J, Bullo-Bonet M, et al. Tumour necrosis factor, a key role in obesity? FEBS Lett 1999(28);451:215-9.
Cummings DE, Schwartz MW. Genetics and pathophysiology of human obesity. Annu Rev Med 2003;54:453-71.
Pi-Sunyer FX. The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 2002;10(Suppl 2):97S-104S.
Bachman, ES, Dhillon, H, Zhang, CY, et al. BetaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 2002;297:843-5.
Tataranni PA, Young JB, Bogardus C, Ravussin E. A low sympathoadrenal activity is associated with body weight gain and development of central adiposity in Pima Indian men. Obes Res 1997;5:341-7.
Power C, Jefferis BJ. Fetal environment and subsequent obesity: a study of maternal smoking. Int J Epidemiol 2002;31:413-9.
Silverman BL, Rizzo TA, Cho NH, Metzger BE. Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care 1998;21(Suppl 2):B142.
Dabelea D, Hanson RL, Lindsay RS, et al. Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 2000;49:2208-11.
Flegal, KM, Troiano, RP, Pamuk, ER, et al. The influence of smoking cessation on the prevalence of overweight in the United States. N Engl J Med 1995;333:1165-70.
Prentice AM, Jebb SA. Obesity in Britain: gluttony or sloth? Br Med J 1995;311:437-9.
Hu FB, Li TY, Colditz GA, Willett WC. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA 2003;289:1785-91.
Robinson TN. Reducing children’s television viewing to prevent obesity: a randomized controlled trial. JAMA 1999;282:1561-7.
Levine JA, Schleusner SJ, Jensen MD. Energy expenditure of nonexercise activity. Am J Clin Nutr 2000;72:1451-4.
Kreier F, Yilmaz A, Kalsbeek A, Romijn JA, Sauerwein HP, et al. Hypothesis: shifting the equilibrium from activity to food leads to autonomic unbalance and the metabolic syndrome. Diabetes 2003;52:2652-6.
Stunkard A, Berkowitz R, Wadden T, et al. Binge eating and the night-eating syndrome. Int J Obes Relat Metab Disord 1996;19:45-62.
Bray, GA. The obese patient: In: Major problems in internal medicine. 9th ed. Philadelphia, PA, USA: W.B. Saunders;1976.