2022, Number 1
Factors favouring a worse clinical course of COVID-19 in people with obesity
Language: Spanish
References: 43
Page: 131-150
PDF size: 509.53 Kb.
ABSTRACT
Introduction: COVID-19 is a disease caused by a new β-coronavirus, which can manifest with a more complex clinical presentation in people with certain comorbidities, on which its evolution may depend; obesity is pointed out among them.Objective: to describe factors favouring a worse clinical course of COVID-19 in people with obesity.
Methods: SciELO, Pubmed, and Google Scholar were used as search engines for scientific information. The search strategy included the following keywords: SARS-CoV-2, COVID-19 and obesity. Review and journal research articles, as well as web pages referring specifically to the study topic and published generally in Spanish, Portuguese and English languages in less than five years were evaluated. This allowed us 70 articles to be evaluated, of which 43 were referenced.
Conclusions: obesity constitutes a disease that worsens the clinical course of COVID-19 by increasing its morbidity and mortality, which is due to several factors related to excess body fat and its consequences.
REFERENCES
Sharma A, Tiwari S, Deb MK, Marty JL. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): A global pandemic and treatment strategies. Int J Antimicrob Agents [internet]. 2020 [citado 14 mayo 2020];56(2):[aprox. 13 p.]. Disponible en: https://www.sciencedirect.com/science/article/pii/S0924857920302247
Wu J, Wu X, Zeng W, Guo D, Fang Z, Chen L, et al. Chest CT findings in patients with coronavirus disease 2019 and its relationship with clinical features. Invest Radiol [internet]. 2020 [citado 21 mar. 2020];55(5):[aprox. 4 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147284/pdf/rli-55-257.pdf
Centro de Coordinación de Alertas y Emergencias Sanitarias. Enfermedad por coronavirus, COVID-19 [internet]. España: Ministerio de Sanidad de España; 2020 [citado 14 mayo 2020]. Disponible en: https://pnsd.sanidad.gob.es/noticiasEventos/actualidad/2020_Coronavirus/pdf/20200421_INFORME_CIENTIFICO_SANIDAD_COVID-19.pdf
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet [internet]. 2020 [citado 14 mayo 2020];395(10223):[aprox. 8 p.]. Disponible en: https://media.tghn.org/articles/99_cases_of_2019_novel_coronavirus_pneumonia_in_Wuhan_China.pdf
Hernández J, Arnold Y, Moncada OM. Prevalencia y tendencia actual del sobrepeso y la obesidad en personas adultas en el mundo. Rev Cubana Endocrinol [internet]. 2019 [citado 30 mayo 2020];30(3):[aprox. 17 p.]. Disponible en: http://www.revendocrinologia.sld.cu/index.php/endocrinologia/article/download/193/167
Bonet M, Varona P. III Encuesta nacional de factores de riesgo y actividades preventivas de enfermedades no trasmisibles. Cuba 2010-2011 [internet]. La Habana: Editorial Ciencias Médicas; 2015 [citado 14 may 2020]. Disponible en: http://www.bvs.sld.cu/libros/encuesta_nacional_riesgo/encuesta_completo.pdf
Petrova D, Salamanca E, Rodríguez M, Navarro P, Jiménez JJ, Sánchez MJ. La obesidad como factor de riesgo en personas conCOVID-19: posibles mecanismos e implicaciones. Aten Primaria [internet]. 2020 [citado 30 mayo 2021];52(7):[aprox. 4 p.]. Disponible en: https://www.elsevier.es/es-revista-atencion-primaria-27-articulo-la-obesidad-como-factor-riesgo-S0212656720301657
Grupo de Análisis Científico de Coronavirus del Instituto de Salud Carlos III. Factores de riesgo en la enfermedad por SARS-CoV-2 (COVID-19) [internet]. España: Ministerio de Ciencia e Innovación; 2020 [citado 30 mayo 2021]. Disponible en: https://www.conprueba.es/sites/default/files/informes/2020-06/FACTORES%20DE%20RIESGO%20EN%20LA%20ENFERMEDAD%20POR%20SARS-CoV-2%20%28COVID-19%29_2.pdf
Pasquarelli do Nascimento G, Braz de Melo HA, Socorro Faria S, de Oliveira I, Kobinger GP, Grace K. Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity. Front Endocrinol [internet]. 2020 [citado 15 sep. 2021];11:[aprox. 1 p.]. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399077/
Movahed MR, Khoubyari R, Hashemzadeh M, Hashemzadeh M. Obesity is strongly and independently associated with a higher prevalence of pulmonary embolism. Respir Invest [internet]. 2019 [citado 30 mayo 2020];57(4):[aprox. 7 p.]. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S221253451830282X?via%3Dihub
Atri D, Siddiqi HK, Lang JP, Nauffal V, Morrow DA, Bohula EA. COVID-19 for the cardiologist: a current review of the virology, clinical epidemiology, cardiac and other clinical manifestations and potential therapeutic strategies. JACC Basic Transl Sci [internet]. 2020 [citado 14 mayo 2020];5(5):[aprox. 18 p.] Disponible en: https://www.jacc.org/doi/pdf/10.1016/j.jacbts.2020.04.002
Raveendrana R, Won J, Chung F. Morbid obesity, sleep apnea, obesity hypoventilation syndrome: Are we sleepwalking into disaster? Perioper Care Oper Room Manag [internet]. 2017 [citado 20 mayo 2020];9:[aprox. 8 p.]. Disponible en: https://www.sciencedirect.com/science/article/abs/pii/S2405603017300456
Barceló A, Elorza MA, Barbé F, Santos C, Mayoralas LR, Agustí AGN. Angiotensin converting enzyme in patients with sleep apnoea syndrome: plasma activity and gene polymorphisms. Eur Respir J [internet]. 2001 [citado 14 mayo 2020];17(4):[aprox. 4 p.]. Disponible en: https://erj.ersjournals.com/content/erj/17/4/728.full.pdf
Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet [internet]. 2020 [citado 14 mayo 2020];395(10229):[aprox. 8 p.]. Disponible en: http://www.epi.uff.br/wp-content/uploads/2013/10/coronavirusriskfactors.pdf
Pinto JA, Ribeiro DK, Cavallini AF, Duarte C, Freitas G. Comorbidities associated with obstructive sleep apnea: a retrospective study. Int Arch Otorhinolaryngol [internet]. 2016 [citado 14 mayo 2020];20(2):[aprox. 5 p.]. Disponible en: https://www.scielo.br/j/iao/a/9DQpQGdJzJ9hW7nKWznW6yJ/?format=pdf&lang=en
Suen CM, Hui DS, Memtsoudis SG, Chung F. Obstructive Sleep Apnea, Obesity, and Noninvasive Ventilation: Considerations During the Coronavirus Disease 2019 Pandemic. Anesth Analg [internet]. 2020 [citado 30 mayo 2020]:[aprox. 5 p.]. Disponible en: https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7202104&blobtype=pdf
Bouillon R, Marcocci C, Carmeliet G, Bokle D, White JH, Dawson Hughes B, et al. Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions. Endocr Rev [internet]. 2019 [citado 20 mayo 2020];40(4):[aprox. 4 p.]. Disponible en: https://academic.oup.com/edrv/article/40/4/1109/5126915?login=true
Jin Y, Cai L, Cheng Z, Cheng H, Deng T, Fan YP, et al. A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res [internet]. 2020 [citado 20 mayo 2020];7(1):[aprox. 5 p.]. Disponible en: https://mmrjournal.biomedcentral.com/articles/10.1186/s40779-020-0233-6