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Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2023, Number 4

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Rev Latin Infect Pediatr 2023; 36 (4)

Why we need more translational research in pediatrics?, the history of immunization against respiratory syncytial virus

Goycochea-Valdivia WA, Olbrich P, Villaverde GS, Mazanares CÁ, Prieto TL, Moraleda C

Language: Spanish
References: 25
Page: 155-160
PDF size: 151.53 Kb.


ABSTRACT

Translational research acts as a bridge facilitating the symbiosis between basic research and clinical research. It seeks to bring the advances of basic research to clinical practice to improve the health of the population, or in a complementary way, to solve clinical problems using basic science. For years, its application in pediatrics has been a real challenge, requiring adapted infrastructures, compliance with more demanding regulatory and ethical requirements, and the preparation and recognition of personnel with specific training. The story of the successful development of a population immunization strategy against the respiratory syncytial virus, a pathogen with the great morbidity and mortality in infants and historically elusive to the development of preventive and therapeutic solutions, demonstrates in an exemplary way the potential of translational research in pediatrics. This review article summarizes how applied translational research was able to solve this pediatric clinical problem and highlights the future challenges for the rational development of vaccines and therapeutics for the pediatric population.


REFERENCES

  1. Comisión de Salud Pública del Consejo Interterritorial del Sistema Nacional de Salud. Recomendaciones de utilización de nirsevimab frente a virus respiratorio sincitial para la temporada 2023-2024. Ministerio de Sanidad; 2023. Disponible en: https://www.sanidad.gob.es/areas/promocionPrevencion/vacunaciones/comoTrabajamos/docs/Nirsevimab.pdf

  2. Comité Asesor de Vacunas (CAV-AEP). Virus respiratorio sincitial. Manual de inmunizaciones en línea de la AEP [Internet]. Madrid: AEP; 2023. Disponible en: http://vacunasaep.org/documentos/manual/cap-33

  3. Acosta PL, Caballero MT, Polack FP. Brief history and characterization of enhanced respiratory syncytial virus disease. Clin Vaccine Immunol. 2015; 23 (3): 189-195. doi: 10.1128/CVI.00609-15.

  4. Mejias A, Rodriguez-Fernandez R, Peeples ME, Ramilo O. Respiratory syncytial virus vaccines: are we making progress? Pediatr Infect Dis J. 2019; 38 (10): e266-e269. doi: 10.1097/INF.0000000000002404.

  5. Dormitzer PR, Grandi G, Rappuoli R. Structural vaccinology starts to deliver. Nat Rev Microbiol. 2012; 10 (12): 807-813. doi: 10.1038/nrmicro2893.

  6. Kaler J, Hussain A, Patel K, Hernandez T, Ray S. Respiratory syncytial virus: a comprehensive review of transmission, pathophysiology, and manifestation. Cureus. 2023; 15 (3): e36342. doi: 10.7759/cureus.36342.

  7. Li Y, Wang X, Blau DM, Caballero MT, Feikin DR, Gill CJ et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis. Lancet. 2022;399(10340):2047-2064. doi: 10.1016/S0140-6736(22)00478-0.

  8. Rosas-Salazar C, Chirkova T, Gebretsadik T, Chappell JD, Peebles RS Jr, Dupont WD et al. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study. Lancet. 2023; 401 (10389): 1669-1680. doi: 10.1016/S0140-6736(23)00811-5.

  9. Langedijk AC, Bont LJ. Respiratory syncytial virus infection and novel interventions. Nat Rev Microbiol. 2023; 21 (11): 734-749. doi: 10.1038/s41579-023-00919-w.

  10. De Gregorio E, Rappuoli R. From empiricism to rational design: a personal perspective of the evolution of vaccine development. Nat Rev Immunol. 2014; 14 (7): 505-514. doi: 10.1038/nri3694.

  11. Muller WJ, Madhi SA, Seoane Nuñez B, Baca Cots M, Bosheva M, Dagan R et al. Nirsevimab for prevention of RSV in term and late-preterm infants. N Engl J Med. 2023; 388 (16): 1533-1534. doi: 10.1056/NEJMc2214773.

  12. Kampmann B, Madhi SA, Munjal I, Simões EAF, Pahud BA, Llapur C et al. Bivalent prefusion f vaccine in pregnancy to prevent RSV illness in infants. N Engl J Med. 2023; 388 (16): 1451-1464. doi: 10.1056/NEJMoa2216480.

  13. Zerhouni EA. Translational and clinical science--time for a new vision. N Engl J Med. 2005; 353 (15): 1621-1623. doi: 10.1056/NEJMsb053723.

  14. Fox RJ. Translational and clinical science. N Engl J Med. 2006; 354 (9): 978-979. doi: 10.1056/NEJMc053105.

  15. Connor E, Lombardi D, van den Anker J. More than baby steps: perspectives on pediatric translational research. Sci Transl Med. 2009; 1 (2): 2cm2. doi: 10.1126/scitranslmed.3000152.

  16. Connor EM, Smoyer WE, Davis JM, Zajicek A, Ulrich L, Purucker M et al. Meeting the demand for pediatric clinical trials. Sci Transl Med. 2014; 6 (227): 227fs11. doi: 10.1126/scitranslmed.3008043.

  17. Brinkley WR. Disappearing physician-scientists. Science. 1999; 283 (5403): 791. doi: 10.1126/science.283.5403.791b.

  18. Williams CS, Rathmell WK, Carethers JM, Harper DM, Lo YMD, Ratcliffe PJ et al. A global view of the aspiring physician-scientist. Elife. 2022; 11: e79738. doi: 10.7554/eLife.79738.

  19. Strong MJ, Busing N, Goosney DL, Harris KA, Horsley T, Kuzyk A et al. The rising challenge of training physician-scientists: recommendations from a Canadian National Consensus Conference. Acad Med. 2018; 93 (2): 172-178. doi: 10.1097/ACM.0000000000001857.

  20. Garrison HH, Ley TJ. Physician-scientists in the United States at 2020: Trends and concerns. FASEB J. 2022; 36 (5): e22253. doi: 10.1096/fj.202200327.

  21. Butler D. Translational research: crossing the valley of death. Nature. 2008; 453 (7197): 840-842. doi: 10.1038/453840a.

  22. Kools FRW, Fox CM, Prakken BJ, van Rijen HVM. One size does not fit all: an exploratory interview study on how translational researchers navigate the current academic reward system. Front Med (Lausanne). 2023; 10: 1109297. doi: 10.3389/fmed.2023.1109297.

  23. Moore DJ, Powell W, Boyer D, Bline K, Harshman L, Nowalk A et al. National Pediatrician-Scientist Collaborative Workgroup comment on new ACGME requirements' impact on pediatric physician-scientists. Pediatr Res. 2023. doi: 10.1038/s41390-023-02795-9.

  24. Utz PJ, Jain MK, Cheung VG, Kobilka BK, Lefkowitz R, Yamada T et al. Translating science to medicine: The case for physician-scientists. Sci Transl Med. 2022; 14 (632): eabg7852. doi: 10.1126/scitranslmed.abg7852.

  25. McLellan JS, Chen M, Joyce MG, Sastry M, Stewart-Jones GB, Yang Y et al. Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science. 2013; 342 (6158): 592-598. doi: 10.1126/science.1243283. Erratum in: Science. 2013; 342 (6161): 931.




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