Reyes-Gómez U, Lira-Rodríguez MC, Virgen-Ortega C, Echeverria-Mayrén C, Reyes-Hernández MU, Márquez-Celedonio FG, Matos-Alviso LJ, Cuevas-López LL, Reyes-Hernández KL, López-Cruz G, Pérez-Pacheco O, Hernández-Lira I, Perea-Martínez A, Ríos-Gallardo PT

Language: Spanish
References: 22
Page: 143-147
PDF size: 189.88 Kb.

ABSTRACT

Introduction: paracetamol is a drug very frequently used in pediatrics and this is indicated above all for its antipyretic and analgesic effect. Under the objective of knowing the acceptance of the flavor that three commercial brands keep, the present investigation was carried out. Material and methods: in a prospective, comparative and blinded study in a sample composed of 47 students, 29 (61.7%) women and 18 (38.3%) men, the evaluation was carried out taking the Likert scale as a measurement instrument, they should have a minimum of three hours of fasting. They were given these trade brands to try, both the evaluator and the evaluated did not know which commercial brand this corresponded to, these were classified as A, B and C. Results: an overall score of 3.43 ± 0.97 (range 1 to 5) was obtained for Tempra, 4.72 ± 0.45 (range 4 to 5) for Tylenol and 2.13 ± 0.85 (range 1 to 5) for Son's Piral, finding statistically significant differences globally and between each of the drug presentations (p < 0.00001). Conclusion: the Tylenol trademark was the one with the best acceptance with a statistically significant value. These results should be considered in the prescription of this antipyretic-analgesic. Even though this evaluation was carried out in adolescents and adults, it serves as the basis for prescribing it to children and achieving better compliance with the doses by prescribing the one with the best acceptance.

REFERENCES

1. Reyes-Gómez U, Reyes-Hernández U, López-Cruz G, Sánchez-Chávez NP, Reyes-Hernández D, Colón-Cuesta F, et al. Aceptación del sabor de antiinflamatorios de presentación liquida en un grupo de adolescentes. Bol Clin Hosp Infant Edo Son. 2009;26(1):3-7.

2. El-Chaar GM, Mardy G, Wehlou K, Rubin LG. Randomized, double blind comparison of brand and generic antibiotic suspensions: II. A study of taste and compliance in children. Pediatr Infect Dis J. 1996;15(1):18-22.

3. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: WHO; 2003. Available in: https://www.paho.org/en/documents/who-adherence-long-term-therapies-evidence-action-2003

4. Salinas E, Nava M. Adherencia terapéutica. Enf Neurol (Mex). 2012;11(2):102-104.

5. Haynes RB, Yao X, Degani A, Kripalani S, Garg A, McDonald HP. Interventions to enhance medication adherence. Cochrane Database Syst Rev. 2005;(4):CD000011.

6. Frank ME, Bouverat BP, MacKinnon BI, Hettinger TP. The distinctiveness of ionic and nonionic bitter stimuli. Physiol Behav. 2004;80(4):421-431.

7. Villegas-Ruíz X, Ruíz-Espinosa H, Bárcenas-Pozos ME. Tecnologías de enmascaramiento de sabor amargo en alimentos. Temas Selectos de Ingeniería de Alimentos. 2010;4(1):27-36.

8. Boreus LO. Principles of pediatrics pharmacology. New York: Churchill Livingstone; 1982. pp. 176-179.

9. Matas A. Diseño del formato de escalas tipo Likert: un estado de cuestión REDIE. 2018;20(1):201-205.

10. Reyes HMU, Lira RC, Echeverria MC, Reyes HK, Reyes HU, Hernández MR, et al. Evaluación de la aceptación del sabor con la escala Likert de tres marcas comerciales de sulfametoxazol/trimetropim en su presentación líquida. Enf Infec Microbiol. 2021;41(1):17-21.

11. Hernández-Cortez E. Acetaminofén: el medicamento más usado en pediatría. Anest Méx. 2016;28(3):1-4.

12. Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, Bickler S, Brennan T, et al. Management of postoperative pain: a clinical practice guideline from the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131-157.

13. Tan E, Braithwaite I, McKinlay CJD, Dalziel SR. Comparison of acetaminophen (paracetamol) with ibuprofen for treatment of fever or pain in children younger than 2 years: a systematic review and meta-analysis. JAMA Netw Open. 2020;3(10):e2022398. doi: 10.1001/jamanetworkopen.2020.22398.

14. Lundeberg S. Pain in children--are we accomplishing the optimal pain treatment? Paediatr Anaesth. 2015;25(1):83-92.

15. Reyes HKL, Reyes GU, Reyes MHA, Guerrero BM, Gutiérrez PDM, Santos Salazar L, et al. Evaluación de la aceptación del sabor de azálidos y macrólidos en suspensión reconstituida y en presentación líquida. Enf Infec Microbiol. 2019;39(2):56-58.

16. Reyes-Hernández KL, Reyes-Martínez H, Reyes-Gómez U, Ahuja-Coca IE, Barrita-Morga B, Chagoya-Peralta JC. Aceptación del sabor de dos dicloxacilinas y una cefalosporina de primera generación. Rev Mex Pediatr. 2015;82(6):197-199.

17. Hernández LS, Reyes GU, Reyes HK, Reyes HD, Ávila CP, Reyes HU, et al. Aceptación del sabor de las cefalosporinas de segunda y tercera generación en suspensión reconstituida. Enf Inf Microbiol. 2013;33(4):152-155.

18. Arredondo GJ, Campos SA, Contestabile MA, Flores DJ, Arcos CG, Galicia LR. Cefalosporinas orales en infecciones respiratorias. Rev Enfer Infec Pediatr. 2012;25.26(102):217-224.

19. Rodrigo C. Uso de los antimicrobianos en la población pediátrica. Enferm Infecc Microbiol Clin. 2010;28(5):310-320.

20. Díez-Gandía A, Aroca Ajenjo M, González Navalón AB, Ballester Fernández R, Ballester Sanz A, Díez-Domingo J. Palatabilidad de las soluciones de rehidratación oral en niños de 6 a 9 años. Ensayo clínico multicéntrico, aleatorizado y simple ciego. An Pediatr (Barc). 2010;72(2):111-115.

21. Chavez-Bueno S, Stull TL. Antibacterial agents in pediatrics. Infect Dis Clin North Am. 2009;23(4):865-880.

22. De la Flor BJ. Fiebre; utilización de analgésicos y antitérmicos Pediatría Integral (Barc). 2014;18(1):44-47.