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2023, Number 5

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Med Crit 2023; 37 (5)

Difference in serum interleukin 6 levels in pediatric patients with sepsis of bacterial and viral etiology

Quiñonez ÁMF, Garay CDG, Casillas CMC, Silva RH, Rendón MME, Blanco MA

Language: Spanish
References: 17
Page: 399-404
PDF size: 203.37 Kb.


ABSTRACT

Introduction: pediatric sepsis is considered a major cause of morbidity and mortality; the measurement of serum IL-6 has demonstrated a useful tool for early diagnosis and improved prognosis for this condition. Objective: we aimed to evaluate the diagnostic validity of IL-6 serum levels in pediatric patients with severe sepsis in order to determine non-COVID viral or bacterial etiologies. Material and methods: a prospective transversal cohort of 111 patients with suspected sepsis whose etiological agent was confirmed via molecular diagnosis was done. Results: pathogenic etiology was identified in 40 patients (36%), of which 26 were of viral origin and 14 bacterial. IL-6 levels were higher in patients with bacterial septic etiology versus viral (38.4 versus 7.3 pg/mL, p = 0.01). A positive correlation was found between IL-6 levels and C-reactive protein (r = 0.76; p = 0.006). Conclusion: the systematic measurement of plasmatic IL-6 facilitates a more precise diagnosis with the correlation of other infectious biomarkers.


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