2022, Number 283
Structural proteins as the molecular basis of SARSCoV- 2 infection
Language: Spanish
References: 10
Page: 1-2
PDF size: 324.49 Kb.
Text Extraction
Mr. editor:The new coronavirus named SARS-CoV-2, which causes zoonotic COVID-19 disease, emerged in the city of China, Wuhan and spread worldwide with a record of alarming numbers. The World Health Organization declared it an international health emergency in January 2020 and despite countless efforts to contain its rapid spread, it was classified as a pandemic.
SARS-CoV-2 belongs to a diverse family of single-stranded positive-sense RNA viruses. In humans, four endemic coronaviruses (HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1) are known to cause mild respiratory symptoms in most cases; a picture that is in contrast to the manifestations caused by the new strain, which is characterized by a febrile state, general symptoms, intense cough and dyspnea. Twenty-five percent of cases develop an acute respiratory syndrome due to pneumonia, leading to multiorgan failure.
REFERENCES
2 Seroconversion in Humans:A Detailed Protocol for a SerologicalAssay, Antigen Production, andTest Setup. CPMicrobiol [Internet].2020 [citado 28/02/2021]; 57(1):1-15. Disponible en: https://doi.org/10.1002/cpmc.1002. Belasco Silvia AG, Cassiane Dezotida F. Coronavirus 2020. RevBras Enferm [Internet]. 2020 [citado28/02/2021]; 73(2):1-2. Disponibleen: https://doi.org/10.1590/0034-7167-2020730201
Xintian X, Ping C, Jingfang W,Jiannan F, Hui Z, Xuan L. Evolutionof the novel coronavirus from theongoing Wuhan outbreak and modelingof its spike protein for riskof human transmissio. Sci ChinaLife Sci [Internet]. 2020 [citado28/02/2021]; 63(3):457-460. Disponibleen: https://doi.org/10.1007/s11427-020-1637-5