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2006, Number S4

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Arch Cardiol Mex 2006; 76 (S4)

Molecular bases of heart failure

Rodríguez PJM, Gallardo GJ, Vargas AG

Language: Spanish
References: 44
Page: 10-17
PDF size: 135.41 Kb.


ABSTRACT

Heart failure (HF) is a complex pathophysiologic state in which delivery of blood and nutrients is inadequate for tissue requirements. HF almost always arises in patients with previous cardiovascular disease such as acute myocardial infarction, atherosclerosis, cardiomyopathy, myocarditis, congenital malformations, or valvular disease. Recently, substantial progress has been made to understand the etiology, pathogenesis, and mechanisms of HF. Several interrelated mechanisms such as oxidative stress, signal transduction, abnormalities in intracellular calcium handling, mitochondrial dysfunction and inherited mutations have been proposed as the triggers of HF.


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